Natchez, MS Office Spaces for Sale

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Vidalia, LA Ferriday, LA Roxie, MS Clayton, LA Fayette, MS Waterproof, LA Jonesville, LA Crosby, MS

20 properties

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Updated: May 20

Multi-Building Office Property

131 Jefferson Davis Boulevard, Natchez, MS 39120

$1,990,000

24,060 sqft 3.44 AC lot

Two office buildings totaling 24,060 +/- rentable square feet
3.44‑acre tract with multiple offices in each building
Individual buildings contain 8,444 +/- and 15,616 +/- rentable square feet
New 20‑year roofs installed on both buildings
Interior spaces can be combined or divided into larger or smaller suites

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Updated: Dec 12, 2025

Mixed-Use Building with Basement

326-328 Main Street, Natchez, MS 39120

$675,000

5,304 sqft 0.06 AC lot

5,304‑square‑foot building on a 0.06‑acre lot
Two stories with a full basement
Currently used as a real estate office and boutique
Upper‑level two‑bedroom, two‑bathroom apartment under construction
Roof installed in 2022

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Medical Office Building

500 N Martin Luther King Street, Natchez, MS 39120

$275,000

4,583 sqft 0.70 AC lot

B-1 neighborhood business zoning supports a multi-room layout with reception, offices, restrooms, and patient areas.

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Historic Mixed-Use Building

326328 326-328 Main St, Natchez, MS 39120

$675,000

5,304 sqft

Two-story commercial property with a full basement, period details, and an apartment under construction upstairs.

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Brick Office Building with Covered Drive-Through

329 Lower Woodville Road, Natchez, MS 39120

$195,000

3,204 sqft 0.44 AC lot

Interior rooms, storage, office space, and a covered vehicle passage provide a flexible existing layout.

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Historic Mixed-Use Building

126 S Commerce Street, Natchez, MS 39120

$495,000

9,500 sqft

An interior hydraulic elevator serves the upper floor alongside a separate staircase.

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Two-Building Office Property

255 Highway 61, Natchez, MS 39120

$525,000

3,500 sqft 0.51 AC lot

Brick office improvements on a 0.51-acre site include a leased single-story building and a separate two-story structure.

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Flexible Multi-Office Buildings

131 Jefferson Davis Boulevard, Natchez, MS 39120

$1,990,000

24,060 sqft 3.44 AC lot

Two buildings provide adaptable office layouts and established occupancy across a commercial tract.

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Four-Office Flex Building

235 Highway 61, Natchez, MS 39120

$195,000

2,450 sqft 0.88 AC lot

The property combines office rooms with a substantial rear warehouse area.

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Historic Two-Story Mixed-Use Building

126 S Commerce St, Natchez, MS 39120

$495,000

9,500 sqft

Downtown property combines office and retail suites with an elevator, basement storage, and existing individual occupants.

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Two-Building Office Property

255 Highway 61, Natchez, MS 39120

$525,000

3,500 sqft

Two brick office buildings on a compact commercial lot, including one leased building with an existing two-year term.

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Historic Two-Story Office Building

412 Main St, Natchez, MS 39120

$349,000

3,420 sqft

Two-story office building with a renovated main level and an upper level that needs rehabbing.

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Flex Space with Rear Warehouse

235 Highway 61, Natchez, MS 39120

$195,000

2,450 sqft

Four offices complement dedicated rear warehouse space in a practical commercial configuration.

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Spa and Wellness Commercial Building

151 E Franklin St, Natchez, MS 39120

$225,000

2,436 sqft

Commercial property with prior beauty and spa use and flexibility for office or retail occupancy.

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Brick Office Building with Covered Drive-Through

329 Lower Woodville Rd, Natchez, MS 39120

$195,000

3,204 sqft

Interior includes reception space, two large rooms, storage, an office, and a half bath.

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Updated Medical Office Space

B-142 Jefferson Davis Blvd, Natchez, MS 39120

$220,000

1,800 sqft

Refreshed interiors provide flexible rooms for examinations, administration, and day-to-day office operations.

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Office Building with Full Kitchen

154 Providence Road, Natchez, MS 39120

$415,000

Includes conference space, separate restrooms, a private sauna, and off-street parking.

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Renovated Mixed-Use Corner Building

701 Franklin St, Natchez, MS 39120

$325,000

3,069 sqft

Single-story property combines an adaptable commercial area with a private one-bedroom residence and separate entrance.

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Retail Space with Display Windows

290 Sergeant Prentiss Dr, Natchez, MS 39120

Contact for pricing

Flexible commercial space with updated finishes, two breakrooms or offices, and two bathrooms.

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Commercial Land on Corporate Blvd

526 Highway 61 North, Natchez, MS 39120

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Land suitable for retail or office with highway visibility.

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Based on your search, we've compiled Potential Opportunities for your consideration. Besides 20 Active Listings in Natchez, MS, we suggest to view alternatives - similar 52 Off-Market properties to explore as potential leads.

Off-Market Properties in Natchez, MS

Consider similar Off-Market properties in Natchez, MS. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

OFFICE (GENERAL)

642 Hwy 61st N, Natchez, MS 39120-9102

Estimated value:

$205,000

2,460 sqft 0.65 AC lot

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OFFICE (GENERAL)

Hwy 61st S, Natchez, MS 39120

Estimated value:

$285,000

2,762 sqft 6.20 AC lot

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OFFICE (GENERAL)

101 Clifton Ave, Natchez, MS 39120-2305

Estimated value:

$295,000

5,061 sqft 0.32 AC lot

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OFFICE (GENERAL)

129 Commerce St, Natchez, MS 39120-3307

Estimated value:

$280,000

1,505 sqft 2,713.41 AC lot

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Natchez, MS Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Natchez, MS, showcased through 20 active listings on our real estate platform. These investment opportunities span a total of 111,344 square feet of properties for sale, with an estimated market value of $9,959,000.

Sale prices for office properties in Natchez, MS start at $195,000, averaging $553,277, and reaching up to $1,990,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 29K

Population Growth (5Y) -6.5%

Median Household Income $40,586

College Educated 9.0%

High-Yield Neighborhoods for Investment

Identify Natchez submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
39120	$553.5K

Taxes & Financing

Average Loan-to-Value 65.0%

Total CRE Inventory on Market (SF)

How Realmo verifies these figures

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