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    Natchez, MS Office Spaces for Sale

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    Vidalia, LA Ferriday, LA Clayton, LA Waterproof, LA Roxie, MS Jonesville, LA Woodville, MS Lorman, MS
    10 properties
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    Two-Building Office Property
    Updated: May 20
    Two-Building Office Property

    131 Jefferson Davis Boulevard, Natchez, MS 39120

    $2,355,000
    24,060 sqft 3.44 AC lot
    Total of 24,060 +/- rentable square feet across two buildings.
    Two buildings included on a 3.44 acre tract.
    New 20‑year roofs recently installed on both buildings.
    Buildings designed for flexible modular interior spaces to accommodate various tenant needs.
    151 Jeff Davis Drive contains 15,616 +/- rentable sq ft.
    View details
    Medical Office Building with Patient Rooms
    Updated: Dec 4, 2025
    Medical Office Building with Patient Rooms

    500 N Martin Luther King Street, Natchez, MS 39120

    $275,000
    4,583 sqft 0.70 AC lot
    Over 4,500 SF building built in 1978, previously used as a medical facility in Natchez
    Large reception and waiting room area
    Multiple patient rooms, offices, and restrooms on each side for flexible shared‑practice layouts
    Zoned B‑1 (neighborhood business district)
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    Historic Two-Story Office and Retail
    Historic Two-Story Office and Retail

    126 S Commerce Street, Natchez, MS 39120

    $495,000
    9,500 sqft

    Two-story brick building offers finished office and retail space with an elevator and interior stair access.

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    Commercial Property on Sgt Prentiss
    Commercial Property on Sgt Prentiss

    260 Sgt Prentiss Dr, Natchez, MS 39120

    $850,000
    30,000 sqft

    Commercial property with frontage on Sgt Prentiss Drive and Liberty Road.

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    Two-Story Downtown Office Building
    Two-Story Downtown Office Building

    412 Main Street, Natchez, MS 39120

    $389,000
    3,420 sqft

    Two-level building offers renovated main-floor office space and an upper level needing rehabbing.

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    Two-Story Office Building Conversion
    Two-Story Office Building Conversion

    326-328 Main Street, Natchez, MS 39120

    $675,000
    5,304 sqft 0.06 AC lot

    Two-story office building with full basement and historic interior features, plus upper-floor apartment construction.

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    Two Brick Office Buildings
    Two Brick Office Buildings

    255 Highway 61, Natchez, MS 39120

    $525,000
    3,500 sqft 0.51 AC lot

    Two brick office buildings totaling about 5,500 sq ft, including one single-story office leased on a two-year term.

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    Mixed-Use Property with Multiple Buildings
    Mixed-Use Property with Multiple Buildings

    255 US-61, Natchez, MS 39120

    $995,000
    19,434 sqft 4.80 AC lot

    4.8-acre property featuring six freestanding buildings, some currently rented.

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    Flex Space with Rear Warehouse
    Flex Space with Rear Warehouse

    235 Highway 61, Natchez, MS 39120

    $195,000
    2,450 sqft 0.88 AC lot

    Flex property featuring four offices and a large rear warehouse area for a wide range of commercial uses.

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    Commercial Land on Corporate Blvd
    Commercial Land on Corporate Blvd

    526 Highway 61 North, Natchez, MS 39120

    $199,250

    Land suitable for retail or office with highway visibility.

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    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 10 Active listings in Natchez, MS, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 62 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Leased Office Building with Long-Term Tenant
    Leased Office Building with Long-Term Tenant

    502 Mickey Gilley Avenue, Ferriday, LA 71334

    $195,000
    4,000 sqft 100,000.00 AC lot

    Office building currently leased by AT&T under a long-term agreement, providing steady tenant occupancy.

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    Downtown Ferriday Commercial Building
    Downtown Ferriday Commercial Building

    104 Louisiana Ave, Ferriday, LA 71334

    $195,000
    8,000 sqft

    Unique commercial building in downtown Ferriday with available space.

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    Standalone Office Building
    Standalone Office Building

    904 AIRPORT DRIVE, Winnsboro, LA 71295

    $59,500

    Standalone office building on a large lot near the Winnsboro airport and Franklin Medical Hospital.

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    High-Visibility Multi-Use Commercial Building
    High-Visibility Multi-Use Commercial Building

    4288 Front St, Winnsboro, LA 71295

    $179,000

    Versatile property on Front Street suited for self-storage, retail, office, or warehouse operations.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Pad-Ready Commercial Land Lot
    Pad-Ready Commercial Land Lot

    000B3 Highway 61 S, Natchez, MS 39120

    $496,250
    3.54 AC lot

    Lot B-3 is leveled and pad ready with multiple city utilities available along the highway right of way.

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    Pad Ready Land For Sale
    Pad Ready Land For Sale

    Highway 61 lot: B3, Natchez, MS 39120

    $496,250
    3.54 AC lot

    Pad-ready land with utilities in a designated opportunity zone.

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    Commercial Development Land Tract
    Commercial Development Land Tract

    Highway 61 S lot: B5, Natchez, MS 39120

    $248,250
    4.08 AC lot

    Rear lot B-5 includes frontage on a 70-foot ingress/egress right of way and can be combined with adjacent land.

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    Pad Ready Land For Sale
    Pad Ready Land For Sale

    S Highway 61 lot: B2, Natchez, MS 39120

    $496,250
    3.59 AC lot

    Leveled 3.59 acre lot with city utilities available.

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    Off-Market Properties in Natchez, MS

    Consider similar Off-Market properties in Natchez, MS. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    642 Hwy 61st N
    OFFICE (GENERAL)

    642 Hwy 61st N, Natchez, MS 39120-9102

    Value Estimation by Request
    2,460 sqft 0.65 AC lot
    View details
    Hwy 61st S
    OFFICE (GENERAL)

    Hwy 61st S, Natchez, MS 39120

    Value Estimation by Request
    2,762 sqft 6.20 AC lot
    View details
    101 Clifton Ave
    OFFICE (GENERAL)

    101 Clifton Ave, Natchez, MS 39120-2305

    Value Estimation by Request
    5,061 sqft 0.32 AC lot
    View details
    129 Commerce St
    OFFICE (GENERAL)

    129 Commerce St, Natchez, MS 39120-3307

    Value Estimation by Request
    1,505 sqft 2,713.41 AC lot
    View details
    279 Lowr Woodville Rd
    OFFICE (GENERAL)

    279 Lowr Woodville Rd, Natchez, MS 39120-4467

    Value Estimation by Request
    4,937 sqft
    View details
    707 Main St
    OFFICE (GENERAL)

    707 Main St, Natchez, MS 39120-3327

    Value Estimation by Request
    2,288 sqft
    View details
    104 Wall St
    OFFICE (GENERAL)

    104 Wall St, Natchez, MS 39120-3477

    Value Estimation by Request
    6,441 sqft 0.18 AC lot
    View details
    422 Main St
    OFFICE (GENERAL)

    422 Main St, Natchez, MS 39120-3464

    Value Estimation by Request
    4,056 sqft
    View details
    614 Franklin St
    OFFICE (GENERAL)

    614 Franklin St, Natchez, MS 39120-3312

    Value Estimation by Request
    3,720 sqft 0.06 AC lot
    View details
    710 Pearl St
    OFFICE (GENERAL)

    710 Pearl St, Natchez, MS 39120-2359

    Value Estimation by Request
    1,268 sqft 0.08 AC lot
    View details
    Hwy 61st S
    OFFICE (GENERAL)

    Hwy 61st S, Natchez, MS 39120

    Value Estimation by Request
    3,200 sqft
    View details
    175 Sgt Prentiss Dr
    OFFICE (GENERAL)

    175 Sgt Prentiss Dr, Natchez, MS 39120-4733

    Value Estimation by Request
    836 sqft
    View details
    207 Commerce St
    OFFICE (GENERAL)

    207 Commerce St, Natchez, MS 39120-3501

    Value Estimation by Request
    2,152 sqft 0.05 AC lot
    View details
    400 Greenfield Rd
    OFFICE (GENERAL)

    400 Greenfield Rd, Natchez, MS 39120-8742

    Value Estimation by Request
    1,168 sqft 10.13 AC lot
    View details

    Natchez, MS Office Spaces Market Trends and Statistics

    Explore 72 office spaces for sale in Natchez, MS, showcased through 10 active listings on our real estate platform. These investment opportunities span a total of 102,251 square feet of properties for sale, with an estimated market value of $6,754,000.

    Sale prices for office spaces in Natchez, MS start at $195,000, averaging $750,444, and reaching up to $2,355,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 6
    Office buildings 5
    Medical Office Space 3

    Demographics Overview

    Population 29K
    Population Growth (5Y) -6.5%
    Median Household Income $40,586
    College Educated 9.0%

    High-Yield Neighborhoods for Investment

    Identify Natchez submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    39120 $678.8K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Total CRE Inventory on Market (SF)

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