Natchez, MS Mixed-use Properties for Sale

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Updated: Dec 12, 2025

Mixed-Use Building with Basement

326-328 Main Street, Natchez, MS 39120

$675,000

5,304 sqft 0.06 AC lot

5,304‑square‑foot building on a 0.06‑acre lot
Two stories with a full basement
Currently used as a real estate office and boutique
Upper‑level two‑bedroom, two‑bathroom apartment under construction
Roof installed in 2022

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Updated: May 16

Historic Mixed-Use Building

126 S Commerce Street, Natchez, MS 39120

$495,000

9,500 sqft

Approximately 9,500 +/- square feet of finished space, plus a basement of approximately 1,750 square feet
Two floors with approximately seven first‑floor offices and approximately eight second‑floor offices
Second floor includes storage rooms and three restrooms; first floor has a break room and restroom
Interior staircase and hydraulic elevator provide access to the upper level
Brick building dating to 1871; restoration and rehabilitation completed in 1982

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Historic Mixed-Use Building

326328 326-328 Main St, Natchez, MS 39120

$675,000

5,304 sqft

Two-story commercial property with a full basement, period details, and an apartment under construction upstairs.

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Historic Two-Story Mixed-Use Building

126 S Commerce St, Natchez, MS 39120

$495,000

9,500 sqft

Downtown property combines office and retail suites with an elevator, basement storage, and existing individual occupants.

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Williams Isles House Mixed-Use Property

657 S Canal St, Natchez, MS 39120

$225,000

2,658 sqft

The property combines commercial and residential zoning with a commercial kitchen, high ceilings, and wood floors.

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Historic Mixed-Use Property

604 Franklin St, Natchez, MS 39120

$334,500

3,341 sqft

Combines professional office space with two separately accessed residential apartments.

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Renovated Mixed-Use Corner Building

701 Franklin St, Natchez, MS 39120

$325,000

3,069 sqft

Single-story property combines an adaptable commercial area with a private one-bedroom residence and separate entrance.

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Historic Multi-Level Restaurant Property

619 Jefferson Street, Natchez, MS 39120

$499,000

5,396 sqft

Antebellum brick-and-wood building includes former restaurant space and two first-floor restrooms.

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Based on your search, we've compiled 59 Potential Opportunities for your consideration. Besides 8 Active listings in Natchez, MS, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 47 Off-Market properties to explore as potential leads

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Mixed-Use Property with Banking Suite

1405 Aston Ave, Mccomb, MS 39648

$450,000

6,000 sqft 0.61 AC lot

Multi-tenant commercial property includes storefront, church, and banking-oriented improvements.

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Multi-Unit Mixed-Use Property

219225 219-225 State St, Mccomb, MS 39648

$239,500

4,356 sqft

Four-unit commercial building with office and retail layouts, including two spaces available for occupancy or lease.

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Mixed-Use Commercial Building

391 Brookhaven St, Brookhaven, MS 39601

$399,500

2,762 sqft

Flexible space supports retail, office, or combined commercial use with on-site parking.

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Mixed-Use Building with Living Quarters

1111 Dummy Line Road, Brookhaven, MS 39601

Contact for pricing

Steel-frame commercial building with enclosed work and storage space, private living quarters, parking, and on-site water service.

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Off-Market Properties in Natchez, MS

Consider similar Off-Market properties in Natchez, MS. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

STORE/OFFICE (MIXED USE)

402 Main St, Natchez, MS 39120-3464

Estimated value:

$245,000

2,271 sqft

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STORE/OFFICE (MIXED USE)

303 Devereaux Dr, Natchez, MS 39120-4207

Estimated value:

$1,530,000

14,985 sqft 1.74 AC lot

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STORE/OFFICE (MIXED USE)

345 Devereaux Dr, Natchez, MS 39120-4207

Estimated value:

$1,495,000

20,356 sqft 1.13 AC lot

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STORE/OFFICE (MIXED USE)

412 Hwy 61st N, Natchez, MS 39120-4200

Estimated value:

$755,000

7,334 sqft

View details

STORE/OFFICE (MIXED USE)

114 Northgate Rd, Natchez, MS 39120-9161

Estimated value:

$680,000

11,160 sqft 1.66 AC lot

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STORE/OFFICE (MIXED USE)

15 Spg St, Natchez, MS 39120-2838

Estimated value:

$195,000

3,150 sqft 0.15 AC lot

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STORE/OFFICE (MIXED USE)

624 Hwy 61st N, Natchez, MS 39120-8405

Estimated value:

$230,000

4,219 sqft

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Multifamily properties

131 Winchester Rd, Natchez, MS 39120

Estimated value: by Request

6,676 sqft 10.60 AC lot

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Individual retail properties

939 Us-61, Natchez, MS 39120

Estimated value: by Request

3,000 sqft 4.37 AC lot

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Mixed-use properties

245 Us-61, Natchez, MS 39120

Estimated value: by Request

2,450 sqft 0.45 AC lot

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Individual retail properties

61 251&255 Hwy, Natchez, MS 39120

Estimated value: by Request

2,000 sqft 0.51 AC lot

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Individual retail properties

255 Us-61, Natchez, MS 39120

Estimated value: by Request

19,434 sqft 4.80 AC lot

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Distribution properties

235 Highway 61, Natchez, MS 39120

Estimated value: by Request

2,450 sqft 0.88 AC lot

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STORE/OFFICE (MIXED USE)

Shields Ln, Natchez, MS 39120

Estimated value:

$555,000

4,400 sqft 1.05 AC lot

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STORE/OFFICE (MIXED USE)

270 Sgt Prentiss Dr, Natchez, MS 39120

Estimated value:

$240,000

979 sqft 0.52 AC lot

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STORE/OFFICE (MIXED USE)

49 Sgt Prentiss Dr, Natchez, MS 39120-4727

Estimated value:

$465,000

15,027 sqft 1.77 AC lot

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Natchez, MS Mixed-Use Properties Market Trends and Statistics

Explore 55 mixed-use properties for sale in Natchez, MS, showcased through 8 active listings on our real estate platform. These investment opportunities span a total of 44,072 square feet of properties for sale, with an estimated market value of $3,723,500.

Sale prices for multi use buildings in Natchez, MS start at $225,000, averaging $465,437, and reaching up to $675,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 29K

Population Growth (5Y) -6.5%

Median Household Income $40,586

College Educated 9.0%

High-Yield Neighborhoods for Investment

Identify Natchez submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
39120	$472.3K

Taxes & Financing

Average Loan-to-Value 65.0%

Total CRE Inventory on Market (SF)

How Realmo verifies these figures

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Natchez, MS Mixed-use Properties for Sale

326-328 Main Street, Natchez, MS 39120

126 S Commerce Street, Natchez, MS 39120

326328 326-328 Main St, Natchez, MS 39120

126 S Commerce St, Natchez, MS 39120

657 S Canal St, Natchez, MS 39120

604 Franklin St, Natchez, MS 39120

701 Franklin St, Natchez, MS 39120

619 Jefferson Street, Natchez, MS 39120

Opportunities in Nearby Cities

1405 Aston Ave, Mccomb, MS 39648

219225 219-225 State St, Mccomb, MS 39648

391 Brookhaven St, Brookhaven, MS 39601

1111 Dummy Line Road, Brookhaven, MS 39601

Off-Market Properties in Natchez, MS

402 Main St, Natchez, MS 39120-3464

303 Devereaux Dr, Natchez, MS 39120-4207

345 Devereaux Dr, Natchez, MS 39120-4207

412 Hwy 61st N, Natchez, MS 39120-4200

114 Northgate Rd, Natchez, MS 39120-9161

15 Spg St, Natchez, MS 39120-2838

624 Hwy 61st N, Natchez, MS 39120-8405

131 Winchester Rd, Natchez, MS 39120

939 Us-61, Natchez, MS 39120

245 Us-61, Natchez, MS 39120

61 251&255 Hwy, Natchez, MS 39120

255 Us-61, Natchez, MS 39120

235 Highway 61, Natchez, MS 39120

Shields Ln, Natchez, MS 39120

270 Sgt Prentiss Dr, Natchez, MS 39120

49 Sgt Prentiss Dr, Natchez, MS 39120-4727

Natchez, MS Mixed-Use Properties Market Trends and Statistics

Top Commercial Asset Segments

Demographics Overview

High-Yield Neighborhoods for Investment

Taxes & Financing

Total CRE Inventory on Market (SF)

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