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    Natchez, MS Commercial Real Estate for Lease

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    Jackson, MS Ridgeland, MS Hattiesburg, MS
    10 results
    Downtown Natchez Office Space
    $800 /Mo
    1,000 SF

    Downtown Natchez Office Space

    104 S Wall Street, Natchez, MS 39120

    Recently renovated office space for lease in downtown Natchez.

    • Prime downtown Natchez location across from the courthouse
    • Recently renovated office space
    • Utilities included in monthly rent
    • Includes reception area, 2 offices, and a break room
    • Approximately 1000‑1200 square feet of space
    Updated: Oct 20, 2025
    View details
    Natchez Office Space For Rent
    $1,500 /Mo
    1,100 SF

    Natchez Office Space For Rent

    151 Jefferson Davis Blvd lot: B, Natchez, MS 39120

    Commercial office space suitable for medical, wellness, or professional use.

    • Prime location in a highly sought‑after area of Natchez, MS.
    • Move‑in ready condition, ideal for immediate occupancy.
    • Well‑designed layout featuring five private exam/office rooms.
    • Suitable for medical, wellness, or professional services.
    • Includes a large waiting area and dedicated reception space.
    Updated: May 16, 2025
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    Natchez Office Space For Rent
    $1,250 /Mo
    950 SF

    Natchez Office Space For Rent

    950 sq ft office space in Natchez, Mississippi.

    151 Jefferson Davis Boulevard lot: E, Natchez, MS 39120
    View details
    Retail Space in Natchez, MS
    $4,000 /Mo
    4,000 SF

    Retail Space in Natchez, MS

    4,000 sq ft retail space for rent in Natchez.

    414 Hwy 61 N, Natchez, MS 39120
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    Downtown Natchez Renovated Office Space
    $1,200 /Mo
    1,200 SF

    Downtown Natchez Renovated Office Space

    Recently renovated office space for lease in downtown Natchez.

    104 S Wall St, Natchez, MS 39120
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    Northgate Shopping Center Retail Space
    $14 SF/Yr

    Northgate Shopping Center Retail Space

    Retail spaces available in Northgate Shopping Center.

    105 Northgate Road, Natchez, MS 39120
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    Retail Space in Natchez Mall
    Contact for pricing
    3,500 SF

    Retail Space in Natchez Mall

    Retail space available in established Natchez Mall.

    350 John Junkin Drive, Natchez, MS
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    Medical Office Shell Space
    $20 SF/Yr
    3,080 SF

    Medical Office Shell Space

    3,080 SF shell space in Class A medical office.

    46 Sgt Prentiss Pkwy, Natchez, MS
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    Medical Office Space Near Hospital
    Contact for pricing

    Medical Office Space Near Hospital

    Class A medical building adjacent to Merit Health Natchez hospital.

    46 Sgt Prentiss Dr, Natchez, MS 39120
    View details
    Natchez Commercial Outparcel Opportunity
    Contact for pricing

    Natchez Commercial Outparcel Opportunity

    Outparcel on Devereux Drive near Vowell’s Cash Saver.

    261 Devereux Dr, Natchez, MS 39120
    View details
    Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 10 Active listings in Natchez, MS, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 62 Properties for Sales.

    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    New Commercial Building in Newellton
    $439,000

    New Commercial Building in Newellton

    New commercial building suitable for retail, office, or medical use.

    1106 Verona Street, Newellton, LA 71357
    View details
    Vidalia Commercial Property For Rent
    $2,650 /Mo
    2,650 SF

    Vidalia Commercial Property For Rent

    Commercial property with office, crane shed, and storage shed.

    1074 J Logan Sewell Drive, Vidalia, LA 71373
    View details
    Newellton Freestanding Building For Lease
    $7,622 /Mo
    10,163 SF

    Newellton Freestanding Building For Lease

    New freestanding building suitable for retail, office, or medical uses.

    1106 Verona St, Newellton, LA
    View details
    Former Restaurant with Drive-Thru
    Contact for pricing
    2,913 SF

    Former Restaurant with Drive-Thru

    2,913 SF former Burger King with drive-thru and pylon signage.

    1115 Carter St, Vidalia, LA 71373
    View details

    Explore Similar Spaces for Sale in Natchez, MS

    Consider Similar Space for Sale. We found 62 Spaces matching your search parameters.

    Natchez Medical Facility For Sale
    $275,000
    4,583 SF

    Natchez Medical Facility For Sale

    Over 4,500 SF commercial building in Natchez, Mississippi.

    500 N Martin Luther King Street, Natchez, MS 39120
    View details
    Natchez Commercial Building For Sale
    $375,000
    6,780 SF

    Natchez Commercial Building For Sale

    Commercial building in high-visibility area with reliable tenants.

    55 E Franklin Street lot: B, Natchez, MS 39120
    View details
    Turnkey Car Wash Package Sale
    $6,500,000
    3,529 SF

    Turnkey Car Wash Package Sale

    Two car wash locations sold as a package in Natchez, MS.

    273 John R Junkin Drive, Natchez, MS 39120
    View details
    Commercial Building with Potential Uses
    $225,000
    3,750 SF

    Commercial Building with Potential Uses

    Commercial building with potential for various uses in Natchez, MS.

    335 Lower Woodville Road, Natchez, MS 39120
    View details
    Prime Commercial Lot on Junkin
    $495,000
    0.73 Acres

    Prime Commercial Lot on Junkin

    High-traffic lot with potential for various commercial uses.

    465 John R Junkin Drive, Natchez, MS 39120
    View details
    Commercial Building with High Visibility
    $210,000
    0.44 Acres

    Commercial Building with High Visibility

    Spacious brick building with potential for many uses.

    329 Lower Woodville Road, Natchez, MS 39120
    View details
    Versatile Commercial Space in Natchez
    Contact for pricing
    1,600 SF

    Versatile Commercial Space in Natchez

    Adaptable 1,600 sq ft space suitable for various businesses.

    151 Jefferson Davis Boulevard, Natchez, MS 39120
    View details
    Historic Kings Tavern Building For Sale
    $440,000
    3,744 SF

    Historic Kings Tavern Building For Sale

    Three-level antebellum structure in historic Natchez, Mississippi.

    613 Jefferson Street, Natchez, MS 39120
    View details
    Downtown Natchez Mixed-Use Opportunity
    $875,000
    4,400 SF

    Downtown Natchez Mixed-Use Opportunity

    Two-story historical building in downtown Natchez with commercial and residential potential.

    433 Main Street, Natchez, MS 39120
    View details
    Turn-Key Automotive Detail Shop
    $199,000
    1,720 SF

    Turn-Key Automotive Detail Shop

    Automotive detail shop with equipment in Natchez, Mississippi.

    1169 Dr. Martin Luther King Jr., Natchez, MS 39120
    View details
    Historic Building in Natchez, MS
    $51,500
    500 SF

    Historic Building in Natchez, MS

    Historic commercial building in Natchez, Mississippi, for sale.

    12 4th Street lot: B-2, Natchez, MS 39120
    View details
    Commercial Lot in High-Traffic Area
    $165,000

    Commercial Lot in High-Traffic Area

    Commercial lot in high-traffic area with good visibility.

    Sergeant Prentiss Drive, Natchez, MS 39120
    View details
    Natchez Commercial Property with Warehouses
    $419,000
    10,656 SF

    Natchez Commercial Property with Warehouses

    Commercial property with two warehouses, near Highway 61 South.

    18 Col. John Pitchford Parkway, Natchez, MS 39120
    View details
    Commercial Land on John R Junkin
    $335,500
    1.39 Acres

    Commercial Land on John R Junkin

    Commercial land with frontage on John R Junkin Drive.

    John R Junkin Drive, Natchez, MS 39120
    View details

    Natchez, MS Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Natchez, MS with 10 listings featured on our commercial real estate exchange. The current inventory includes 307,098,000 square feet of properties with an estimated lease value of $53 SF/Yr.

    Estimated lease rates for Commercial real estate in Natchez, MS begin at $9 SF/Yr, with an average of $13 SF/Yr and extend to $16 SF/Yr.
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