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    Clayton, MO Office Properties & Spaces for Sale

    7 results
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    Clayton Mixed-Use Renovation Opportunity
    $275,000
    2,356 SF

    Clayton Mixed-Use Renovation Opportunity

    6325 Clayton Road, Clayton, MO 63117

    Mixed-use property in Clayton's Live Work Overlay District.

    • Prime Location: Short walk to Forest Park and one block to SSM St Mary's medical complex, with easy highway access.
    • Live/Work Potential: Situated in Clayton's Live Work Overlay District, offering mixed‑use possibilities (50%+ residential).
    • High Visibility & Dual Parking: Fantastic visibility with high traffic count and dual parking access from front and rear.
    • Spacious Interior: Over 2300 sq ft with high ceilings, abundant natural light, and a full basement with walk‑up exit.
    • Updated Systems: Newer HVAC and updated electric.
    Updated: Mar 10
    View details
    Clayton CBD Freestanding Building
    $1,499,000
    5,573 SF

    Clayton CBD Freestanding Building

    7530 Maryland Ave, Clayton, MO

    Architecturally significant building in Clayton CBD, suitable for various uses.

    • Prime Clayton CBD location offering potential for luxury single‑family home or duplex conversion.
    • Architecturally significant building designed by William B. Ittner with historic details.
    • Boasts substantial square footage: Nearly 6,400 SF across 1st & 2nd floors, plus a 3,300 SF basement.
    • Flexible R‑2 zoning allows for residential, office, educational, or mixed‑use development without zoning variance.
    • Unique features include a terrazzo staircase, 3 fireplaces, and a boardroom.
    Updated: Jul 14, 2025
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    Clayton Road Retail Opportunity
    $5,995,000
    8,500 SF

    Clayton Road Retail Opportunity

    Retail and office spaces available in prime Clayton location.

    8211-8221 Clayton Rd, Clayton, MO
    View details
    Clayton Office Building For Sale
    $2,295,000
    19,330 SF

    Clayton Office Building For Sale

    Prime location with highway access and parking.

    889 S Brentwood Blvd, Clayton, MO
    View details
    Clayton Road Commercial Property For Sale
    $1,900,000
    7,200 SF

    Clayton Road Commercial Property For Sale

    Commercial property available for sale on Clayton Road.

    6369 Clayton Rd, Clayton, MO 63117
    View details
    Clayton Office Building For Sale
    $2,295,000
    19,330 SF

    Clayton Office Building For Sale

    19,330 SqFt office building in Clayton, Missouri.

    889 S Brentwood Blvd, Clayton, MO 63105
    View details
    26,400 SF Clayton Office Building
    Contact for pricing
    26,400 SF

    26,400 SF Clayton Office Building

    Free-standing building in downtown Clayton with covered parking.

    10 N Hanley Rd, Clayton, MO
    View details
    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 7 Active listings in Clayton, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 5 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Prime Richmond Heights Office Space
    Contact for pricing
    1,000 SF

    Prime Richmond Heights Office Space

    Spacious office suites in a high-visibility Richmond Heights location.

    1047 S Big Bend Boulevard, Richmond Heights, MO 63117
    View details
    Office Building in Clayton, MO
    Contact for pricing
    10,535 SF

    Office Building in Clayton, MO

    Office building in a bustling downtown area.

    8077 Maryland Ave, Saint Louis, MO
    View details
    Richmond Heights Office Building For Sale
    Contact for pricing
    58,249 SF

    Richmond Heights Office Building For Sale

    Office building in Richmond Heights, Missouri, with value-add opportunity.

    7700-7750 Clayton Rd, Richmond Heights, MO
    View details
    St. Louis Office Building For Sale
    $1,595,000
    5,380 SF

    St. Louis Office Building For Sale

    Office building with 5380 square feet available for sale.

    Saint Louis, MO 63117
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Mixed-Use Property in Maplewood
    $1,699,000
    10,257 SF

    Mixed-Use Property in Maplewood

    Versatile property with retail, office, and residential spaces.

    7420 Manchester Road, St, Louis, MO 63143
    View details
    Vacant Lot in St. Louis
    Contact for pricing

    Vacant Lot in St. Louis

    Residential lot in established St. Louis neighborhood, close to amenities.

    5089 Raymond Avenue, St, Louis, MO 63113
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    Commercial Land in St Louis
    $100,000
    0.07 Acres

    Commercial Land in St Louis

    Level commercial land in the Forest Park Southeast Neighborhood.

    4481 Hunt Avenue, St, Louis, MO 63110
    View details
    Flex Office Warehouse Building For Sale
    $8,950,000
    135,074 SF

    Flex Office Warehouse Building For Sale

    135,000 SF flex building in Overland, MO with I-170 frontage.

    2001 Walton Road, St, Louis, MO 63114
    View details

    Explore Off-Market Properties in Clayton, MO

    Consider similar Off-Market properties in Clayton, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    212 Central Ave

    212 Central Ave

    Office properties & Spaces • 56,000 SF
    Value Estimation by Request
    212 Central Ave, Clayton, MO 63105
    View details
    7733 Forsyth Blvd

    7733 Forsyth Blvd

    Coworking space • 15,190 SF
    Value Estimation by Request
    7733 Forsyth Blvd, Clayton, MO 63105
    View details
    225-235 Meramec Ave

    225-235 Meramec Ave

    Medical Office Space • 102,600 SF
    Value Estimation by Request
    225-235 Meramec Ave, Clayton, MO 63105
    View details
    8001 Forsyth Blvd

    8001 Forsyth Blvd

    Office properties & Spaces • 282,000 SF
    Value Estimation by Request
    8001 Forsyth Blvd, Clayton, MO 63105
    View details
    34 Brentwood Blvd

    34 Brentwood Blvd

    Office properties & Spaces • 34,200 SF
    Value Estimation by Request
    34 Brentwood Blvd, Clayton, MO 63105
    View details

    Clayton, MO Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 12 office properties & spaces for sale in Clayton, MO, showcased through 7 active listings on our real estate platform. These investment opportunities span a total of 3,485 square feet of properties for sale, with an estimated market value of $275,000.

    Sale prices for office spaces in Clayton, MO start at $275,000, averaging $275,000, and reaching up to $275,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Browse Office properties & Spaces for Sale Near Clayton, MO

    Popular Searches in Clayton, MO

    Most Searched ZIP Codes in Clayton, MO

    • 63117
    • 63105

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