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    Anderson, SC Office Spaces for Lease

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    Starr, SC Pendleton, SC Belton, SC
    17 properties
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    Main Street Office Space Available
    Updated: Feb 6
    Main Street Office Space Available

    2315 N Main Street, Anderson, SC 29621

    $3,400/Mo
    23,000 sqft · $1.77 SF/Yr
    Class A office building in a prime location on Main Street
    2,800 sf first‑floor office space
    Large parking lot available for tenants and visitors
    Signage available to enhance your business visibility
    Maintenance, electric, and water included for hassle‑free operations
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    Class A Office Space
    Updated: Nov 13, 2025
    Class A Office Space

    2315 N Main Street, Anderson, SC 29621

    $3,400/Mo
    Prime Main Street location ideal for high‑visibility professional business.
    Class A office building with included maintenance, electric, and water.
    Versatile 2,800 sq ft suite suitable for medical or professional use.
    Functional layout with five private offices, open floor plan, two restrooms, and a kitchen area.
    Includes a welcoming reception area and large parking space.
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    Office Suite with High-End Finishes
    Office Suite with High-End Finishes

    1801 North Main Street, Anderson, SC 29621

    $18 SF/Yr
    1,800 sqft · $2,700/Mo

    Well-finished office suite with private offices, conference space, ample parking, and strong visibility for professional teams.

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    Endcap Retail or Office Space
    Endcap Retail or Office Space

    1638 North Main Street, Anderson, SC 29621

    $11 SF/Yr
    2,696 sqft · $2,471/Mo

    Endcap space with strong daily traffic, signalized access, and 47 parking spaces for retail or office users.

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    Renovated Office Building For Rent
    Renovated Office Building For Rent

    1311 South Murray Avenue, Anderson, SC 29624

    $1,300/Mo
    1,300 sqft · $12 SF/Yr

    Renovated office building with versatile space for rent.

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    Office Space Near Downtown Anderson
    Office Space Near Downtown Anderson

    1214 North Main Street, Anderson, SC 29621

    $1,200/Mo
    900 sqft · $16 SF/Yr

    Office suite with three private offices, reception, and kitchenette.

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    Flex Building with Office, Warehouse
    Flex Building with Office, Warehouse

    109 Old Denver Road, Anderson, SC 29625

    $4,000/Mo
    3,200 sqft · $15 SF/Yr

    Flex building with office and warehouse space for lease.

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    Miracle Mile Commercial Building
    Miracle Mile Commercial Building

    102 Miracle Mile Dr, Anderson, SC 29621

    $10 SF/Yr
    4,000 sqft · $3,500/Mo

    Approximately 4000 SF building for lease with high visibility.

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    Modern Office Space Available
    Modern Office Space Available

    521 N Mcduffie St, Anderson, SC 29621

    $500/Mo

    Updated office space with 9 offices, conference room, and breakroom.

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    Office Spaces Available For Lease
    Office Spaces Available For Lease

    210 N Mcduffie St, Anderson, SC 29621

    $550/Mo

    Office spaces available for lease in Anderson, South Carolina.

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    Industrial Building Near I-85
    Industrial Building Near I-85

    1046 Watkins Road, Anderson, SC 29625

    Contact for pricing
    8,850 sqft

    8,850 SF industrial building with fenced yard near I-85.

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    Former Bank Branch with Drive-Thru
    Former Bank Branch with Drive-Thru

    3898 Liberty Highway, Anderson, SC 29621

    $18 SF/Yr

    Former bank branch with drive-thru located near major retailers.

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    Downtown Anderson Office Space
    Downtown Anderson Office Space

    211 West Whitner Street, Anderson, SC 29624

    $12 SF/Yr

    Office space available for lease in downtown Anderson.

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    East Greenville Street Office Space
    East Greenville Street Office Space

    1403 East Greenville Street, Anderson, SC 29621

    Contact for pricing
    2,000 sqft

    Office or medical suite with ample parking and high visibility.

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    Office Space with Recent Upgrades
    Office Space with Recent Upgrades

    120 E West Pkwy, Anderson, SC

    $5,000/Mo
    4,200 sqft · $14 SF/Yr

    Office space featuring new exterior paint and resurfaced parking lot.

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    Professional Office Space Available
    Professional Office Space Available

    341 E Beltline Blvd, Anderson, SC

    Contact for pricing
    3,000 sqft

    Well-maintained office park near US 178/N. Main St.

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    Oak Point Plaza Retail Opportunity
    Oak Point Plaza Retail Opportunity

    4120-4126 Clemson Blvd, Anderson, SC 29621

    $12 SF/Yr
    57,107 sqft · $57,107/Mo

    Multi-tenant plaza near I-85 and Clemson University for lease.

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    Based on your search, we've compiled 46 Potential Opportunities for your consideration. Besides 17 Active listings in Anderson, SC, we suggest exploring alternatives. Similar 29 Properties for Sales.

    Similar Spaces for Sale in Anderson, SC

    Consider Similar Space for Sale. We found 29 Spaces matching your search parameters.

    Flex-Use Retail and Office Building
    Flex-Use Retail and Office Building

    1804 S McDuffie Street, Anderson, SC 29624

    $255,000
    0.28 AC lot

    Fully fenced flex-use building with an oversized side-entry garage and heated main space for retail, office, or dining concepts.

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    Commercial Property Near Downtown Anderson
    Commercial Property Near Downtown Anderson

    3499 East River Street, Anderson, SC 29621

    $429,000
    2,430 sqft · 0.64 AC lot

    Well-maintained flex building with office and warehouse space.

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    Two-Story Retail and Office Plaza
    Two-Story Retail and Office Plaza

    2406, 2408, 2410 N Main Street, Anderson, SC 29621

    $1,990,000

    Two-story plaza with 12 shop and office units plus a rear entrance for added tenant access flexibility.

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    Prime Commercial Land I-85 Frontage
    Prime Commercial Land I-85 Frontage

    105 Destination Boulevard, Anderson, SC 29621

    $949,000
    1.80 AC lot

    High-traffic commercial land with I-85 frontage in Anderson, SC.

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    Warehouse & Flex Space Facility
    Warehouse & Flex Space Facility

    109 Waybrook Drive, Anderson, SC 29624

    $425,000
    3.11 AC lot

    Clear-span warehouse with flex-style potential, roll-up loading, and commercial/industrial zoning for a range of operations.

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    Prime Anderson Business Location
    Prime Anderson Business Location

    2006 N Main Street, Anderson, SC 29621

    $499,000
    0.25 AC lot

    Excellent visibility, move-in ready office space with parking.

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    Office Building with Multiple Entrances
    Office Building with Multiple Entrances

    2006 N Main Street, Anderson, SC 29621

    $499,000
    0.25 AC lot

    Move-in-ready office property with paved front and rear parking, a heated/cooled sunroom, and flexible room layout.

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    Anderson, SC Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Anderson, SC with 17 listings featured on our commercial real estate exchange. The current inventory includes 101,803 square feet of properties with an estimated lease value of $153 SF/Yr.

    Estimated lease rates for Office Spaces in Anderson, SC begin at $1.77 SF/Yr, with an average of $12 SF/Yr and extend to $18 SF/Yr.
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    Most Searched ZIP Codes in Anderson, SC

    • 29621
    • 29625
    • 29624

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