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    Portsmouth, NH Office Properties & Spaces for Lease

    64 results
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    Retail/Office Space in Portsmouth
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    Retail/Office Space in Portsmouth

    33 Deer St, Portsmouth, NH 03801

    Updated retail/office space with patio in revitalized North End.

    • Prime location on desirable Deer Street in Portsmouth's revitalized North End.
    • Newly updated interior with fresh paint and new flooring.
    • Generous patio/outdoor space adjacent to the Sheraton Hotel and Conference Center.
    • One included underground parking space.
    • Rent includes water, sewer, and trash.
    Updated: Jan 16
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    Portsmouth Office Space For Lease
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    48,787 SF

    Portsmouth Office Space For Lease

    500 Maplewood Ave, Portsmouth, NH 03801

    Versatile office space in Portsmouth, accessible from city or bypass.

    • Convenient location off Route 1 Bypass, accessible from the city.
    • Versatile first‑floor layout with open showroom/bullpen, 8 private offices, and 2 conference/team rooms.
    • Includes a kitchen and 2 restrooms.
    • Additional storage rooms on the first floor.
    • Large, unfinished 3,921sf second‑floor space suitable for storage or future office build‑out.
    Updated: Dec 30, 2025
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    Prime Portsmouth Commercial Space Available
    Contact for pricing
    174,240 SF

    Prime Portsmouth Commercial Space Available

    High-traffic location suitable for retail, medical, restaurant, or office use.

    750 Lafayette Rd, Portsmouth, NH 03801
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    Downtown Portsmouth Modern Office Space
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    Downtown Portsmouth Modern Office Space

    Modern office space in downtown Portsmouth with parking and amenities.

    299 Hanover St, Portsmouth, NH 03801
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    Portsmouth Office Space For Lease
    $10 SF/Yr
    8,202 SF

    Portsmouth Office Space For Lease

    Versatile office space available for lease in Portsmouth, New Hampshire.

    500 Maplewood Ave, Portsmouth, NH 03801
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    Versatile Commercial Space on Lafayette Road
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    174,240 SF

    Versatile Commercial Space on Lafayette Road

    Adaptable space suitable for medical, retail, restaurant, or office use.

    750 Lafayette Rd, Portsmouth, NH 03801
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    Prime Portsmouth Commercial Space Available
    Contact for pricing
    4,792 SF

    Prime Portsmouth Commercial Space Available

    1,470 SF office/retail space in high-traffic Portsmouth location.

    1290 Woodbury Ave, Portsmouth, NH 03801
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    Portsmouth Office Building For Lease
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    Portsmouth Office Building For Lease

    Office building for lease with high visibility and signage.

    3201 Lafayette Rd, Portsmouth, NH 03801
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    Downtown Portsmouth Office Suites Available
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    Downtown Portsmouth Office Suites Available

    Move-in-ready office suites in a vibrant downtown location.

    10 Vaughan St, Portsmouth, NH 03801
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    Downtown Portsmouth Office Space Available
    Contact for pricing

    Downtown Portsmouth Office Space Available

    Move-in-ready office suites in a vibrant, walkable downtown location.

    10 Vaughan St, Portsmouth, NH 03801
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    Professional Office Space For Lease
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    1,500 SF

    Professional Office Space For Lease

    Individual offices for healthcare practitioners and therapists in Portsmouth, NH.

    4 Greenleaf Woods Dr, Portsmouth, NH 03801
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    Downtown Portsmouth Office Space Available
    Contact for pricing

    Downtown Portsmouth Office Space Available

    Move-in-ready office suites in a vibrant downtown location.

    10 Vaughan St, Portsmouth, NH 03801
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    Portsmouth Medical Office Space
    $19 SF/Yr
    55,200 SF

    Portsmouth Medical Office Space

    Prime Medical Suites, I-95 Access

    330 Borthwick Ave, Portsmouth, NH 03801
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    Portsmouth Office Space For Lease
    $10 SF/Yr
    8,202 SF

    Portsmouth Office Space For Lease

    8,202 SF Office, Prime Location

    500 Maplewood Ave, Portsmouth, NH 03801
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    Vaughan Mall Office Suites
    $18 SF/Yr
    38,745 SF

    Vaughan Mall Office Suites

    Portsmouth, NH Office Space Available

    10 Vaughan Mall, Portsmouth, NH 03801
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    Historic Portsmouth Office Building
    $30 SF/Yr
    4,928 SF

    Historic Portsmouth Office Building

    Spacious Office Space Available, Prime Location

    110 Chapel St, Portsmouth, NH 03801
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    Portsmouth Office/Storage Space Available
    $14 SF/Yr
    62,322 SF

    Portsmouth Office/Storage Space Available

    900 SF heated space, prime Portsmouth location.

    300 Constitution Ave, Portsmouth, NH 03801
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    Prime Pease Tradeport Office Space
    $17 SF/Yr
    14,800 SF

    Prime Pease Tradeport Office Space

    Modern Executive Suites, 14,800 SF Available

    183 International Dr, Portsmouth, NH 03801
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    Portsmouth Office Suites for Lease
    $23 SF/Yr
    58,347 SF

    Portsmouth Office Suites for Lease

    Affordable NH Office Space, 120-204 SF

    170 West Rd, Portsmouth, NH 03801
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    Portsmouth Executive Office Space
    $28 SF/Yr
    47,745 SF

    Portsmouth Executive Office Space

    Prime Portsmouth Office, Flexible Suites Available

    100 Borthwick Ave, Portsmouth, NH 03801
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    Class A Office Space for Lease
    $12 SF/Yr
    62,322 SF

    Class A Office Space for Lease

    Modern, 11,412 SF Executive Office Suite

    300 Constitution Ave, Portsmouth, NH 03801
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    Prime Portsmouth Medical Office Space
    $38 SF/Yr
    52,000 SF

    Prime Portsmouth Medical Office Space

    Class A Medical Office Suites Available Now

    360 Corporate Dr, Portsmouth, NH 03801
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    Downtown Portsmouth Office Suite
    $29 SF/Yr
    22,148 SF

    Downtown Portsmouth Office Suite

    1600 SF Office, Prime Location

    126 Daniel St, Portsmouth, NH 03801
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    Prime Portsmouth Office Space
    $29 SF/Yr
    57,455 SF

    Prime Portsmouth Office Space

    Class A Executive Suites Available

    100 Market St, Portsmouth, NH 03801
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    Portsmouth, NH Office Properties & Spaces Leasing Opportunities Market Analysis

    Explore Office Properties & Spaces leasing options in Portsmouth, NH with 83 listings featured on our commercial real estate exchange. The current inventory includes 29,854,673,640 square feet of properties with an estimated lease value of $865 /Mo.

    Estimated lease rates for Office Properties & Spaces in Portsmouth, NH begin at $10 SF/Yr, with an average of $22 SF/Yr and extend to $85 SF/Yr.
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    Browse Office Properties & Spaces for Lease Near Portsmouth, NH

    Popular Searches in Portsmouth, NH

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    Most Searched ZIP Codes in Portsmouth, NH

    • 03801
    • 03869

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