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    Durham, NC Office Spaces for Lease

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    Chapel Hill, NC Raleigh, NC Cary, NC
    66 results
    NC, Durham - Spaces Mangum Street
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    NC, Durham - 3511 Shannon Road
    $129-$2,998/Mo
    NC, Durham - 3511 Shannon Road

    3511 Shannon Rd, Durham, NC 27707

    Discover many ways to work your way in NC, Durham - 3511 Shannon Road
    • Be part of a vibrant coworking community with dedicated desk or hot desking options in thousands of idyllic locations across the globe
    • Grow in a modern workplace with the added advantage of a benefits program offering exclusive discounts and bespoke procurement support
    • Access Regus' network of workspaces and business lounges as often as you need and take advantage of their exclusive benefits
    • Impress clients, hold memorable workshops, and deliver a winning pitch in Regus' meeting spaces, fully equipped for gatherings of any size
    • Collaborate with like‑minded professionals and enjoy regular networking and community events with a Regus membership
    Updated: Feb 19
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    CG-Zoned Commercial Space
    $18 SF/Yr
    2,978 SF
    CG-Zoned Commercial Space

    2810 Hillsborough Road, Durham, NC 27705

    High-visibility commercial suite on Hillsborough Road with Commercial General zoning for a broad range of uses.
    • $18/SF/yr lease rate plus TICAM for a 2,978 SF CG‑zoned commercial suite
    • 2,810 Hillsborough Rd sits on a 0.24‑acre parcel on Hillsborough Road in Durham
    • Commercial General (CG) zoning supports a broad range of uses including retail, office, food & beverage, medical, and financial services
    • Located on a high‑traffic corridor connecting Downtown Durham to Duke University
    • Over 181,000 residents within a 5‑mile radius, with population growth projected above 6% through 2030
    Updated: May 18
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    RTP Imperial
    $129-$3,608/Mo
    RTP Imperial

    Discover many ways to work your way in RTP Imperial

    4819 Emperor Blvd, Unit 400, Durham, NC 27703

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    Flexible Office Suite on Highway 54
    $45,045 SF/Yr
    2,145 SF
    Flexible Office Suite on Highway 54

    First-floor office suite with eight private offices, updated interiors, and ample parking on a high-traffic corridor.

    1906 Carolina 54, Durham, NC 27713

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    Professional Office Condos For Lease
    $2,400/Mo
    5,120 SF
    Professional Office Condos For Lease

    Office condos for lease near Duke University Medical Center.

    2741 Campus Walk Ave, Building 400, Durham, NC 27705

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    Versatile Building Available for Lease/Sale
    $3,950,000 SF/Yr
    9,790 SF
    Versatile Building Available for Lease/Sale

    Adaptable building suitable for restaurant, fitness, or office use.

    211 Rigsbee Ave, Durham, NC 27701

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    Prime Medical Office Space Available
    $18 SF/Yr
    2,312 SF
    Prime Medical Office Space Available

    Versatile medical/office space in Durham's thriving North Duke corridor.

    2609 N Duke Street, Durham, NC 27704

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    Plug and Play Lab Space
    $30 SF/Yr
    94,603 SF
    Plug and Play Lab Space

    Move-in ready lab and office space in Durham, NC.

    4025 Stirrup Creek Drive, Durham, NC 27703

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    Roxboro Road Professional Office Space
    $20 SF/Yr
    2,408 SF
    Roxboro Road Professional Office Space

    Office space ideal for professional services and medical offices.

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704

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    Durham Office and Retail Space
    $27 SF/Yr
    16,679 SF
    Durham Office and Retail Space

    Office and retail suites available for lease in Durham.

    404 Hunt Street, Durham, NC 27701

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    RTP Meridian
    $119-$3,403/Mo
    RTP Meridian

    Discover many ways to work your way in RTP Meridian

    2530 Floors, Durham, NC 27713

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    Historic Brick Building in Durham
    $33 SF/Yr
    19,931 SF
    Historic Brick Building in Durham

    Historic 91,168 SF brick building in Durham's Warehouse District.

    333 Liggett Street, Durham, NC 27701

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    Office Space Available For Rent
    $34 SF/Yr
    18,502 SF
    Office Space Available For Rent

    Office space for rent with convenient parking and amenities.

    215 Morris Street, Durham, NC 27701

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    First Floor Office Unit For Lease
    $45,045 SF/Yr
    2,145 SF
    First Floor Office Unit For Lease

    Flexible office unit with ample parking and high traffic count.

    100-a-1906 E Nc Highway 54, Durham, NC 27713

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    Downtown Durham Office Space Available
    $32 SF/Yr
    25,678 SF
    Downtown Durham Office Space Available

    Suites available in historic Art Deco building, downtown Durham.

    331 W Main Street, Durham, NC 27707

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    Luxury Mixed-Use Development Near Duke
    $25 SF/Yr
    118,000 SF
    Luxury Mixed-Use Development Near Duke

    Class A mixed-use development near Duke University and hospitals.

    2812 & 2816 Erwin Rd |, Durham, NC 27705

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    Downtown Durham Office Space Available
    Contact for pricing
    16,692 SF
    Downtown Durham Office Space Available

    Office spaces for lease in the heart of downtown Durham.

    433 W. Main Street, Durham, NC 27701

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    Downtown Durham Office Space
    $38 SF/Yr
    20,126 SF
    Downtown Durham Office Space

    Office space in the heart of Downtown Durham's West Village.

    614 West Main Street, Durham, NC 27701

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    Office Space in Durham
    $30 SF/Yr
    7,943 SF
    Office Space in Durham

    7943 SF office space available for lease.

    700 West Main Street, Durham, NC 27701

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    Office Space Near American Tobacco
    $36 SF/Yr
    15,998 SF
    Office Space Near American Tobacco

    Office space for rent adjacent to Durham's historic district.

    302 East Pettigrew Street, Durham, NC 27701

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    Downtown Durham Office Space
    Contact for pricing
    41,000 SF
    Downtown Durham Office Space

    Full floor office space in downtown Durham's iconic tower.

    212 West Main Street, Durham, NC 27701

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    Renovated Office Building Near University
    Contact for pricing
    58,249 SF
    Renovated Office Building Near University

    Three-story office building near mixed-use development with ongoing renovations.

    3710 University Drive, Durham, NC 27707

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    Durham Office Space For Rent
    $27 SF/Yr
    51,566 SF
    Durham Office Space For Rent

    Office space for rent with easy access to nearby amenities.

    2510 Meridian Parkway, Durham, NC 27713

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    Durham, NC Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Durham, NC with 66 listings featured on our commercial real estate exchange. The current inventory includes 552,647 square feet of properties with an estimated lease value of $4,041,214.

    Estimated lease rates for Office Spaces in Durham, NC begin at $5 SF/Yr, with an average of $144,329 and extend to $3,950,000.
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    Most Searched ZIP Codes in Durham, NC

    • 27701
    • 27713
    • 27703
    • 27707
    • 27705
    • 27704
    • 27215

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