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    Des Moines, IA Office Spaces for Lease

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    Creative Office Building
    Creative Office Building

    118 SE 4th St, Des Moines, IA 50309

    Contact for pricing
    984 sqft

    Renovation underway with space available on both floors and on-site parking for leased use.

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    Office Units
    Office Units

    615 3rd St, Des Moines, IA 50309

    Contact for pricing
    2,016 sqft

    Office space offers immediate interstate access and proximity to Casey’s Center and Hilton Des Moines Downtown.

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    Flex Space with Drive-In Doors
    Flex Space with Drive-In Doors

    101 Sheridan Ave, Des Moines, IA 50313

    Contact for pricing
    12,747 sqft

    Flex space available in an I-1 district with two drive-in doors for convenient loading access.

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    Office Building
    Office Building

    615 3rd St, Des Moines, IA 50309

    Contact for pricing
    6,150 sqft

    Office building with immediate access to I-235 and walkable proximity to Casey’s Center and Hilton Des Moines Downtown.

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    Office Space Available For Lease
    Office Space Available For Lease

    2620 Fleur Dr, Des Moines, IA 50321

    Contact for pricing
    10,816 sqft

    Office property available for lease.

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    Class A Office Building with Retail
    Class A Office Building with Retail

    909 Locust St, Des Moines, IA 50309

    Contact for pricing
    4,029 sqft

    Class A office building with first-floor retail, offering prominent visibility along Locust Street and Grand Avenue.

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    Class A+ Office Building with River Views
    Class A+ Office Building with River Views

    110 E Court Ave, Des Moines, IA 50309

    Contact for pricing
    14,231 sqft

    Class A+ office building with a brand-new lobby, onsite fitness center, and first-floor restaurant space.

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    Downtown Office Tower with Retail
    Downtown Office Tower with Retail

    666 Grand Ave, Des Moines, IA 50309

    Contact for pricing
    120,643 sqft

    34-floor office building offering flexible floor plates and street-level plus skywalk-level retail space.

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    Class A Office and Retail Building
    Class A Office and Retail Building

    400 Locust St, Des Moines, IA 50309

    Contact for pricing
    3,509 sqft

    Eight-story building offers versatile office and retail space with an open atrium design and multiple skywalk access points.

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    Des Moines Office Space Available
    Des Moines Office Space Available

    420 Watson Powell Jr Way, Des Moines, IA 50309

    Contact for pricing
    2,576 sqft 0.90 AC lot

    Office space with skywalk access, natural light, and parking nearby.

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    Historic-Modern Office Building
    Historic-Modern Office Building

    801 Grand Ave, Des Moines, IA 50309

    Contact for pricing
    4,846 sqft

    Office building blending historic accents with contemporary interiors, featuring state-of-the-art amenities and innovative technologies.

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    Downtown Office Building Space
    Downtown Office Building Space

    615 3rd St, Des Moines, IA 50309

    Contact for pricing
    3,600 sqft

    Office building for lease with immediate access to I-235 and a short walk to nearby Casey’s Center and Hilton.

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    Office Suite with Grease Interceptor
    Office Suite with Grease Interceptor

    405 6th Ave, Des Moines, IA 50309

    Contact for pricing
    1,700 sqft

    Office space available at a modified gross rate, with OPEX and TI allowance available upon request.

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    Based on your search, we've compiled 140 Potential Opportunities for your consideration. Besides 86 Active listings in Des Moines, IA, we suggest exploring alternatives. Consider Similar 50 Spaces for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office Space on Hickman Road
    Office Space on Hickman Road

    7900 Hickman Road, Windsor Heights, IA 50324

    $12.50 SF/Yr
    2,344 sqft

    Office space for rent with excellent location and amenities.

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    Second-Floor Office Suites
    Second-Floor Office Suites

    132 1/2 5th Street, West Des Moines, IA 50265

    $2,500/Mo

    Second-floor office space with stair access and visibility on a busy Main Street corridor.

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    Medical Office Space Available
    Medical Office Space Available

    7180 Hickman Road, Windsor Heights, IA 50324

    $9 SF/Yr

    Former orthodontics office with operatories, lab, and private offices.

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    Executive Office Space For Rent
    Executive Office Space For Rent

    917 9th St, West Des Moines, IA

    Contact for pricing
    500.00 AC lot

    Executive office suites with private restroom and signage available.

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    Similar Spaces for Sale in Des Moines, IA

    Consider Similar Space for Sale. We found 50 Spaces matching your search parameters.

    Veterinary Medical Center
    Veterinary Medical Center

    3451 Hubbell Ave, Des Moines, IA 50317

    $985,000
    4,000 sqft

    Freestanding veterinary care facility with an NN lease structure and a five-year renewal option.

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    Standalone One-Story Office Building
    Standalone One-Story Office Building

    2721 SW 30th St, Des Moines, IA 50321

    $590,000
    3,868 sqft 0.63 AC lot

    Flexible professional layout with private offices, conference space, kitchen, and multiple restrooms.

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    Office Building with Finished Basement
    Office Building with Finished Basement

    4001 Ingersoll Avenue, Des Moines, IA 50312

    $576,036
    4,372 sqft

    Mid-century office property with a brick-and-concrete exterior, finished lower level, and on-site parking.

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    Animal Medical Office
    Animal Medical Office

    4520 Merle Hay Rd, Des Moines, IA 50310

    $625,000
    2,250 sqft 0.48 AC lot

    Existing veterinary clinic within a Highway Commercial District property in Des Moines.

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    Office Suite with Skywalk Access
    Office Suite with Skywalk Access

    300 East Walnut Street, Des Moines, IA 50309

    $129,000
    1,467 sqft

    3,500 SF suite offers private offices, a conference room, and a reception area with skywalk connectivity.

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    Office Building with 2025 Roof HVAC
    Office Building with 2025 Roof HVAC

    2301 Rittenhouse Street, Des Moines, IA 50321

    $3,275,000
    29,408 sqft

    Recent roof and HVAC replacement in 2025 support this office building near the Fleur Drive corridor.

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    Des Moines Office Building For Sale
    Des Moines Office Building For Sale

    2620 Fleur Dr, Des Moines, IA 50321

    $800,000
    4,500 sqft

    Office building with 10,816 square feet available for sale.

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    Office Units with Retail Space
    Office Units with Retail Space

    6307 Hickman Road, Des Moines, IA 50322

    $211,213
    2,880 sqft

    Office and retail space is positioned along Hickman Road near Interstate 80/35 access.

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    Des Moines Office Building For Sale
    Des Moines Office Building For Sale

    2100 Fleur Drive, Des Moines, IA 50321

    $2,900,000
    29,289 sqft

    Professional office space with great views and easy airport access.

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    Office
    Office

    2200 Grand Avenue, Des Moines, IA 50312

    $1,075,268
    22,530 sqft

    Office buildings · 22,530 SF

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    One-Story Office Building
    One-Story Office Building

    2721 SW 30th Street, Des Moines, IA 50321

    $565,000
    0.63 AC lot

    Professional layout includes private offices, conference space, a kitchen, and three restrooms for flexible office configurations.

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