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Port St Lucie, FL Office Properties & Spaces for Lease

27 results
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Professional Office Space Available
$2,287 / Mo
998 SF

Professional Office Space Available

2100 SE Hillmoor Dr, Port St Lucie, FL 34952

Class A office suite with private offices and open space.

  • Class A Office Space: Enjoy a high‑quality, professional office environment.
  • Convenient Location: Benefit from close proximity to HCA and major highways.
  • Functional Layout: Features 3 private offices and an open workspace.
  • Accessibility: Located on the 2nd floor with elevator access.
  • Ample Parking: Ensures convenient parking for employees and clients.
Updated: May 18, 2025
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Freestanding Building on US Highway
$26 SF/Yr
46,609 SF

Freestanding Building on US Highway

10244 S Us Highway 1, Port St Lucie, FL 34952

General Commercial zoning ideal for retail, medical, or restaurant.

  • High‑traffic location on US Hwy 1 with 35,500 AADT and 187' frontage.
  • General Commercial zoning suitable for retail, medical, restaurant, or professional use.
  • Ideal sub‑lease option with two separate entrances.
  • Existing electronic and media infrastructure wiring throughout.
  • Modular interior wall system allows for easy reconfiguration.
Updated: Nov 16, 2025
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Medical Office Space For Rent
$24 SF/Yr
998 SF

Medical Office Space For Rent

Updated medical office space available for rent in Port St. Lucie.

1801 SE Hillmoor Dr, Port St Lucie, FL 34952
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Port St. Lucie Executive Office
$1,527 / Mo
998 SF

Port St. Lucie Executive Office

Executive office suite in Port St. Lucie medical corridor.

2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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St. Lucie West Office Space
$23 SF/Yr
2,021 SF

St. Lucie West Office Space

Professional and medical office space in St. Lucie West.

1660 SW St Lucie Blvd W, Port St Lucie, FL
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Executive Office Suites For Rent
$500 / Mo
231 SF

Executive Office Suites For Rent

Executive office suites available for lease in Port St. Lucie.

951 SW Country Clb Dr, Port St Lucie, FL
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Freestanding Office Space Available
$25 SF/Yr

Freestanding Office Space Available

Office space for rent in high-visibility freestanding building.

1399 SE Port St Lucie Blvd, Port St Lucie, FL 34952
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Tradition Village Square Office Space
$27 SF/Yr
28,959 SF

Tradition Village Square Office Space

Office space for lease in vibrant Tradition community.

10801 SW Tradition Sq, Port St Lucie, FL 34987
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Retail/Office Space on US Highway
$12 SF/Yr
19,008 SF

Retail/Office Space on US Highway

Retail, office, or medical spaces with high visibility.

10600-10642 South Federal Hwy, Port St Lucie, FL 34952
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St. Lucie West Professional Office
$23 SF/Yr
4,964 SF

St. Lucie West Professional Office

Professional office space in a convenient St. Lucie West location.

537 NW Lk Whitney Pl, Port St Lucie, FL
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Office Space Available For Rent
Contact for pricing
2,750 SF

Office Space Available For Rent

Office space available for rent in Port St. Lucie, FL.

451 SW Bethany Dr, Port St Lucie, FL
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Professional Office Space Available
$1,750 / Mo
450 SF

Professional Office Space Available

Office sublet with four private offices, shared amenities, utilities included.

1800-1900 SE Prt St, Port St Lucie, FL
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New Professional Office Space Available
$25 SF/Yr
4,130 SF

New Professional Office Space Available

New construction office space for lease in Port St. Lucie.

1380 SW Import Dr, Port St Lucie, FL
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Office/Warehouse Space on Biltmore Street
$1,600 / Mo

Office/Warehouse Space on Biltmore Street

Office and warehouse space available in a prime location.

1720 SW Biltmore St, Port St Lucie, FL 34953
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Visible Corner Office Space Available
$24 SF/Yr
3,900 SF

Visible Corner Office Space Available

Office space with high visibility and convenient access.

481 Southwest Port St Lucie Blvd, Port St Lucie, FL 34953
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Port St. Lucie Flex Warehouse
$20 SF/Yr
26,880 SF

Port St. Lucie Flex Warehouse

Flex warehouse buildings with office space and roll-up doors.

532-534 Northwest Mercantile Pl, Port St Lucie, FL 34986
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Professional Office Space Available
$19 SF/Yr
6,986 SF

Professional Office Space Available

Prime office suites for rent in landmark Port St. Lucie building.

10570 S Us Highway 1, Port St Lucie, FL 34952
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New Medical Building End Cap
$32 SF/Yr
12,784 SF

New Medical Building End Cap

End cap space in a newly constructed medical building.

1070 Southwest Gatlin Blvd, Port St Lucie, FL 34953
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Port St. Lucie Office Space
$13 SF/Yr
8,200 SF

Port St. Lucie Office Space

8,200 SF office space available for lease.

904 E Prima Vista Blvd, Port St Lucie, FL 34952
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New Office/Warehouse Space Available
$20 SF/Yr
992 SF

New Office/Warehouse Space Available

Office/warehouse space with flexible floor plans and high accessibility.

500-510 NW Peacock Blvd, Port St Lucie, FL
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Class A Office Space Available
$22 SF/Yr
3,207 SF

Class A Office Space Available

Professional office building with flexible spaces and modern amenities.

1860 SW Fountainview Blvd, Port St Lucie, FL
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Medical Office Space on Lake
$19 SF/Yr
1,958 SF

Medical Office Space on Lake

Single-story medical office with lake views and recent upgrades.

573 NW Lk Whitney Pl, Port St Lucie, FL
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Medical Office Space on US-1
$18 SF/Yr
5,473 SF

Medical Office Space on US-1

Newly renovated medical space with high visibility and convenient access.

7664 South Hwy U.S, Port St Lucie, FL 34952
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St. Lucie West Office Building
$35 SF/Yr
18,000 SF

St. Lucie West Office Building

Office building in a fast-growing area with excellent visibility.

9265 SW Commerce Ctr Dr, Port St Lucie, FL
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Port St Lucie, FL Office Properties & Spaces Leasing Opportunities Market Analysis

Explore Office Properties & Spaces leasing options in Port St Lucie, FL with 37 listings featured on our commercial real estate exchange. The current inventory includes 9,628,623,113 square feet of properties with an estimated lease value of $584 /Mo.

Estimated lease rates for Office Properties & Spaces in Port St Lucie, FL begin at $12 SF/Yr, with an average of $24 SF/Yr and extend to $46 SF/Yr.
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