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    Port St Lucie, FL Office Properties & Spaces for Lease

    28 results
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    Move-in Ready Executive Office Suite
    $2,451 /Mo
    998 SF

    Move-in Ready Executive Office Suite

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952

    First floor office suite near HCA Florida St. Lucie Hospital.

    • Move‑in ready condition
    • Prime location near HCA Florida St. Lucie Hospital
    • Functional layout featuring a waiting room, reception area, kitchen, and four private offices
    • Located in a high‑demand medical/professional corridor
    • Strong residential density in surrounding area
    Last Update: Dec 4
    View details
    Freestanding Building on US Highway
    $26 SF/Yr
    46,609 SF

    Freestanding Building on US Highway

    10244 S Us Highway 1, Port St Lucie, FL 34952

    General Commercial zoning ideal for retail, medical, or restaurant.

    • High‑traffic location on US Hwy 1 with 35,500 AADT and 187' frontage.
    • General Commercial zoning suitable for retail, medical, restaurant, or professional use.
    • Ideal sub‑lease option with two separate entrances.
    • Existing electronic and media infrastructure wiring throughout.
    • Modular interior wall system allows for easy reconfiguration.
    Last Update: Nov 16
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    Medical Office Space For Rent
    $24 SF/Yr
    998 SF

    Medical Office Space For Rent

    Updated medical office space available for rent in Port St. Lucie.
    1801 SE Hillmoor Dr, Port St Lucie, FL 34952
    View details
    Port St. Lucie Executive Office
    $1,527 /Mo
    998 SF

    Port St. Lucie Executive Office

    Executive office suite in Port St. Lucie medical corridor.
    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Class A Office Suite
    $2,287 /Mo
    998 SF

    Class A Office Suite

    Professional office suite with private offices and open space.
    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Freestanding Office Space Available
    $25 SF/Yr

    Freestanding Office Space Available

    Office space for rent in high-visibility freestanding building.
    1399 SE Port St Lucie Blvd, Port St Lucie, FL 34952
    View details
    Executive Office Suites For Rent
    $500 /Mo
    231 SF

    Executive Office Suites For Rent

    Executive office suites available for lease in Port St. Lucie.
    951 SW Country Clb Dr, Port St Lucie, FL
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    St. Lucie West Office Space
    $23 SF/Yr
    2,021 SF

    St. Lucie West Office Space

    Professional and medical office space in St. Lucie West.
    1660 SW St Lucie Blvd W, Port St Lucie, FL
    View details
    St. Lucie West Professional Office
    $23 SF/Yr
    4,964 SF

    St. Lucie West Professional Office

    Professional office space in a convenient St. Lucie West location.
    537 NW Lk Whitney Pl, Port St Lucie, FL
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    Retail/Office Space on US Highway
    $12 SF/Yr
    19,008 SF

    Retail/Office Space on US Highway

    Retail, office, or medical spaces with high visibility.
    10600-10642 South Federal Hwy, Port St Lucie, FL 34952
    View details
    Tradition Village Square Office Space
    $27 SF/Yr
    28,959 SF

    Tradition Village Square Office Space

    Office space for lease in vibrant Tradition community.
    10801 SW Tradition Sq, Port St Lucie, FL 34987
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    Office Space Available For Rent
    Contact for pricing
    2,750 SF

    Office Space Available For Rent

    Office space available for rent in Port St. Lucie, FL.
    451 SW Bethany Dr, Port St Lucie, FL
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    New Professional Office Space Available
    $25 SF/Yr
    4,130 SF

    New Professional Office Space Available

    New construction office space for lease in Port St. Lucie.
    1380 SW Import Dr, Port St Lucie, FL
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    Professional Office Space Available
    $1,750 /Mo
    450 SF

    Professional Office Space Available

    Office sublet with four private offices, shared amenities, utilities included.
    1800-1900 SE Prt St, Port St Lucie, FL
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    Visible Corner Office Space Available
    $24 SF/Yr
    3,900 SF

    Visible Corner Office Space Available

    Office space with high visibility and convenient access.
    481 Southwest Port St Lucie Blvd, Port St Lucie, FL 34953
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    Port St. Lucie Flex Warehouse
    $20 SF/Yr
    26,880 SF

    Port St. Lucie Flex Warehouse

    Flex warehouse buildings with office space and roll-up doors.
    532-534 Northwest Mercantile Pl, Port St Lucie, FL 34986
    View details
    Office/Warehouse Space on Biltmore Street
    $1,600 /Mo

    Office/Warehouse Space on Biltmore Street

    Office and warehouse space available in a prime location.
    1720 SW Biltmore St, Port St Lucie, FL 34953
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    Professional Office Space Available
    $19 SF/Yr
    6,986 SF

    Professional Office Space Available

    Prime office suites for rent in landmark Port St. Lucie building.
    10570 S Us Highway 1, Port St Lucie, FL 34952
    View details
    New Medical Building End Cap
    $32 SF/Yr
    12,784 SF

    New Medical Building End Cap

    End cap space in a newly constructed medical building.
    1070 Southwest Gatlin Blvd, Port St Lucie, FL 34953
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    Port St. Lucie Office Space
    $13 SF/Yr
    8,200 SF

    Port St. Lucie Office Space

    8,200 SF office space available for lease.
    904 E Prima Vista Blvd, Port St Lucie, FL 34952
    View details
    New Office/Warehouse Space Available
    $20 SF/Yr
    992 SF

    New Office/Warehouse Space Available

    Office/warehouse space with flexible floor plans and high accessibility.
    500-510 NW Peacock Blvd, Port St Lucie, FL
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    Class A Office Space Available
    $22 SF/Yr
    3,207 SF

    Class A Office Space Available

    Professional office building with flexible spaces and modern amenities.
    1860 SW Fountainview Blvd, Port St Lucie, FL
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    Medical Office Space on Lake
    $19 SF/Yr
    1,958 SF

    Medical Office Space on Lake

    Single-story medical office with lake views and recent upgrades.
    573 NW Lk Whitney Pl, Port St Lucie, FL
    View details
    Medical Office Space on US-1
    $18 SF/Yr
    5,473 SF

    Medical Office Space on US-1

    Newly renovated medical space with high visibility and convenient access.
    7664 South Hwy U.S, Port St Lucie, FL 34952
    View details

    Port St Lucie, FL Office Properties & Spaces Leasing Opportunities Market Analysis

    Explore Office Properties & Spaces leasing options in Port St Lucie, FL with 40 listings featured on our commercial real estate exchange. The current inventory includes 9,778,144,028 square feet of properties with an estimated lease value of $584 /Mo.

    Estimated lease rates for Office Properties & Spaces in Port St Lucie, FL begin at $3 SF/Yr, with an average of $22 SF/Yr and extend to $46 SF/Yr.
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    Browse Office Properties & Spaces for Lease Near Port St Lucie, FL

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    Most Searched ZIP Codes in Port St Lucie, FL

    • 34952
    • 34986

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