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    Clayton, MO
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    Clayton, MO Office Buildings for Lease

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    University City, MO Saint Louis, MO Richmond Heights, MO
    7 listings
    Class A Office Tower Clayton
    $35 SF/Yr
    2,610 SF
    Class A Office Tower Clayton

    8235 Forsyth Blvd, Clayton, MO

    Class A office tower in downtown Clayton for lease.
    • Class A office tower in downtown Clayton.
    • Full lobby renovations committed for 2024.
    • Structured parking attached with multiple access points; $2 million in garage updates recently completed.
    • Benefit from on‑site property management & ownership.
    • Conferencing facilities with 3 rooms available.
    Updated: Nov 24, 2025
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    Downtown Clayton Office Building
    $21 SF/Yr
    102,600 SF
    Downtown Clayton Office Building

    225-235 S Meramec Ave, Clayton, MO 63105

    Two interconnected office buildings in downtown Clayton with on-site amenities.
    • Prime Downtown Clayton location with high visibility and close proximity to the Courthouse.
    • Enjoy on‑site amenities including management, post office, cafe, and common space.
    • Abundant parking with a 1,200‑space garage and street parking.
    • Newly built‑out spaces with high‑end finishes.
    • Brand new lobby and updated common areas.
    Updated: Nov 25, 2025
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    Class A Office Tower Clayton
    $35 SF/Yr
    4,086 SF
    Class A Office Tower Clayton

    Class A office tower in downtown Clayton for lease.

    8182 Maryland Ave, Clayton, MO

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    Clayton Office Space For Rent
    $10 SF/Yr
    19,330 SF
    Clayton Office Space For Rent

    Single tenant office building with 19,330 square feet available.

    889 S Brentwood Blvd, Clayton, MO 63105

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    Class A Office Tower Clayton
    $33 SF/Yr
    1,861 SF
    Class A Office Tower Clayton

    Modern office space with comprehensive amenities in Clayton, Missouri.

    101 S Hanley Rd, Clayton, MO

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    Class A+ Office Tower
    $41 SF/Yr
    1,336 SF
    Class A+ Office Tower

    15-story office tower with high-end finishes and convenient access.

    1 N Brentwood Blvd, Clayton, MO

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    Downtown Clayton Office Space Available
    $21 SF/Yr
    102,600 SF
    Downtown Clayton Office Space Available

    Two interconnected office buildings with on-site amenities and parking.

    225-235 S Meramec Ave, Clayton, MO 63105

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    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 7 Active listings in Clayton, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

    Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Renovated Office Building For Rent
    $12 SF/Yr
    2,400 SF
    Renovated Office Building For Rent

    Turnkey office spaces in Overland, MO with excellent accessibility.

    2012 Woodson Rd, Overland, MO

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    Mixed-Use Center Office Space
    Contact for pricing
    15,000 SF
    Mixed-Use Center Office Space

    Office space available in mixed-use lifestyle center with amenities.

    1114 S Brentwood Blvd, Saint Louis, MO 63117

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    Modern Office Space For Rent
    $19 SF/Yr
    14,831 SF
    Modern Office Space For Rent

    Premier office building with modern design elements and ample parking.

    2127 Innerbelt Business Center Dr, Overland, MO

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    Luxury Clayton Mid-Rise Office Building
    $29 SF/Yr
    7,033 SF
    Luxury Clayton Mid-Rise Office Building

    Luxury office building in Clayton, close to amenities and courthouse.

    7800 Forsyth Blvd, Saint Louis, MO

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    Similar Spaces for Sale in Clayton, MO

    Consider Similar Space for Sale. We found 3 Spaces matching your search parameters.

    Clayton CBD Freestanding Building
    $1,499,000
    5,573 SF
    Clayton CBD Freestanding Building

    Architecturally significant building in Clayton CBD, suitable for various uses.

    7530 Maryland Ave, Clayton, MO

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    Clayton Office Building For Sale
    $2,295,000
    19,330 SF
    Clayton Office Building For Sale

    Prime location with highway access and parking.

    889 S Brentwood Blvd, Clayton, MO

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    26,400 SF Clayton Office Building
    Contact for pricing
    26,400 SF
    26,400 SF Clayton Office Building

    Free-standing building in downtown Clayton with covered parking.

    10 N Hanley Rd, Clayton, MO

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Collinsville Commercial Space For Lease
    $5,000/Mo
    5,000 SF
    Collinsville Commercial Space For Lease

    Versatile commercial space in Collinsville, available immediately.

    1902 Vandalia Street, Collinsville, IL 62234

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    High-Traffic Commercial Land in Rolla
    $7,500/Mo
    High-Traffic Commercial Land in Rolla

    0.61 acre commercial land in high-traffic area for lease.

    704 N Bishop Avenue, Rolla, MO 65401

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    Office Development Land For Lease
    Contact for pricing
    4,000 SF
    Office Development Land For Lease

    2.43 acres for office development with build-to-suit opportunity.

    1323 Strawfloor Drive, Jonesboro, AR 72401

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    Commercial Parcel Build-to-Suit Opportunity
    Contact for pricing
    Commercial Parcel Build-to-Suit Opportunity

    Commercial land available for build-to-suit project in Bloomington, Indiana.

    115 W 1st Street, Bloomington, IN 47403

    View details

    Clayton, MO Office buildings Leasing Opportunities Market Analysis

    Explore Office buildings leasing options in Clayton, MO with 7 listings featured on our commercial real estate exchange. The current inventory includes 234,423 square feet of properties with an estimated lease value of $198 SF/Yr.

    Estimated lease rates for Office buildings in Clayton, MO begin at $10 SF/Yr, with an average of $28 SF/Yr and extend to $41 SF/Yr.
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