Office Building

Clayton, MO Office Buildings for Lease

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Downtown Clayton Office Space Available
Updated: Mar 26
Downtown Clayton Office Space Available

225-235 S Meramec Ave, Clayton, MO 63105

$21.50 SF/Yr
102,600 sqft
Prime downtown Clayton location at the corner of Meramec and Shaw Ave.
Ample parking with 1,200 space parking garages adjacent to the building.
On‑site amenities including management, post office, and cafe.
High visibility from Forest Park Parkway.
Close proximity to the Courthouse.
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Renovated Office Space in Clayton
Updated: Nov 22, 2025
Renovated Office Space in Clayton

200 South Hanley Road, Clayton, MO 63105

$18 SF/Yr
30,210 sqft
Convenient Clayton location with outstanding visibility
Newly renovated building lobby, entrance, elevator cabs, and common areas (2022)
Easy access to Forest Park Parkway
Walking distance to numerous restaurants, retail, and hotels
Garage and surface parking available
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Class A Office Tower Clayton
Class A Office Tower Clayton

8182 Maryland Ave, Clayton, MO

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4,086 sqft 0.87 AC lot

Class A office tower in downtown Clayton for lease.

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Based on your search, we've compiled 7 Potential Opportunities for your consideration. Besides 3 Active listings in Clayton, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

Office buildings for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Renovated Office Building Investment Opportunity
Renovated Office Building Investment Opportunity

1530 S Big Bend Blvd, Saint Louis, MO

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2,236 sqft 0.13 AC lot

Fully occupied, renovated 2-unit office building in Richmond Heights.

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Updated Office Building For Lease
Updated Office Building For Lease

12747 Olive Blvd, Creve Coeur, MO

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3,227 sqft 8.28 AC lot

Class B office building with updated common areas and amenities.

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Creve Coeur Office Building
Creve Coeur Office Building

1173 Corporate Lake Dr, Creve Coeur, MO

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15,418 sqft 10.89 AC lot

15,418 SF single-story office building in growing innovation district.

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Luxury Clayton Mid-Rise Office Building
Luxury Clayton Mid-Rise Office Building

7800 Forsyth Blvd, Saint Louis, MO

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7,033 sqft 0.44 AC lot

Luxury office building in Clayton, close to amenities and courthouse.

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Clayton, MO Office buildings Lease Rates & Market Statistics

Browse 3 Office buildings for lease in Clayton, MO on Realmo, a commercial real estate marketplace serving the Clayton area. The current inventory totals 136,896 square feet of properties.

Asking lease rates for Office buildings in Clayton start at $18 SF/Yr, average $19.75 SF/Yr, and reach $21.50 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $19.75 SF/Yr is 21% below the Missouri state average of $25.05 SF/Yr.

Clayton accounts for 4% of the 77 office buildings currently available across St. Louis County, where nearby markets include Saint Louis and Chesterfield. Office buildings are one of the more limited space types in Clayton, with just 3 listings currently available — a scarcity worth factoring into lease negotiations. Also worth a look for tenants weighing alternatives: Office Units (8 listings) elsewhere in the Clayton market.

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