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    Clayton, MO Office Buildings for Lease

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    Saint Louis, MO Louis, MO Kansas City, MO
    7 results
    Downtown Clayton Office Building
    $21 SF/Yr
    102,600 SF

    Downtown Clayton Office Building

    225-235 S Meramec Ave, Clayton, MO 63105

    Two interconnected office buildings in downtown Clayton with on-site amenities.

    • Prime Downtown Clayton location with high visibility and close proximity to the Courthouse.
    • Enjoy on‑site amenities including management, post office, cafe, and common space.
    • Abundant parking with a 1,200‑space garage and street parking.
    • Newly built‑out spaces with high‑end finishes.
    • Brand new lobby and updated common areas.
    Updated: Nov 25, 2025
    View details
    Class A Office Tower Clayton
    $35 SF/Yr
    2,610 SF

    Class A Office Tower Clayton

    8235 Forsyth Blvd, Clayton, MO

    Class A office tower in downtown Clayton for lease.

    • Class A office tower in downtown Clayton.
    • Full lobby renovations committed for 2024.
    • Structured parking attached with multiple access points; $2 million in garage updates recently completed.
    • Benefit from on‑site property management & ownership.
    • Conferencing facilities with 3 rooms available.
    Updated: Nov 24, 2025
    View details
    Class A Office Tower Clayton
    $35 SF/Yr
    4,086 SF

    Class A Office Tower Clayton

    Class A office tower in downtown Clayton for lease.

    8182 Maryland Ave, Clayton, MO
    View details
    Clayton Office Space For Rent
    Contact for pricing
    19,330 SF

    Clayton Office Space For Rent

    Single tenant office building with 19,330 square feet available.

    889 S Brentwood Blvd, Clayton, MO 63105
    View details
    Class A Office Tower Clayton
    $33 SF/Yr
    1,861 SF

    Class A Office Tower Clayton

    Modern office space with comprehensive amenities in Clayton, Missouri.

    101 S Hanley Rd, Clayton, MO
    View details
    Class A+ Office Tower
    $42 SF/Yr
    1,336 SF

    Class A+ Office Tower

    15-story office tower with high-end finishes and convenient access.

    1 N Brentwood Blvd, Clayton, MO
    View details
    Downtown Clayton Office Space Available
    Contact for pricing
    102,600 SF

    Downtown Clayton Office Space Available

    Two interconnected office buildings with on-site amenities and parking.

    225-235 S Meramec Ave, Clayton, MO 63105
    View details
    Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 7 Active listings in Clayton, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

    Explore Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Luxury Clayton Mid-Rise Office Building
    $29 SF/Yr
    7,033 SF

    Luxury Clayton Mid-Rise Office Building

    Luxury office building in Clayton, close to amenities and courthouse.

    7800 Forsyth Blvd, Saint Louis, MO
    View details
    Office Space in Clayton CBD
    Contact for pricing

    Office Space in Clayton CBD

    Office building with tenant amenities and convenient transportation access.

    Saint Louis, MO 63105
    View details
    Centrally Located Office Property
    Contact for pricing

    Centrally Located Office Property

    Office property with on-site management, gym, and updated amenities.

    1034 S Brentwood Blvd, Richmond Heights, MO 63117
    View details
    Remodeled Corporate Center For Rent
    Contact for pricing

    Remodeled Corporate Center For Rent

    Newly remodeled corporate center with covered parking and outdoor patio.

    7700-7750 Clayton Road, Richmond Heights, MO 63117
    View details

    Explore Similar Spaces for Sale in Clayton, MO

    Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

    Clayton CBD Freestanding Building
    $1,499,000
    5,573 SF

    Clayton CBD Freestanding Building

    Architecturally significant building in Clayton CBD, suitable for various uses.

    7530 Maryland Ave, Clayton, MO
    View details
    Clayton Office Building For Sale
    $2,295,000
    19,330 SF

    Clayton Office Building For Sale

    Prime location with highway access and parking.

    889 S Brentwood Blvd, Clayton, MO
    View details
    Clayton Office Building For Sale
    $2,295,000
    19,330 SF

    Clayton Office Building For Sale

    19,330 SqFt office building in Clayton, Missouri.

    889 S Brentwood Blvd, Clayton, MO 63105
    View details
    26,400 SF Clayton Office Building
    Contact for pricing
    26,400 SF

    26,400 SF Clayton Office Building

    Free-standing building in downtown Clayton with covered parking.

    10 N Hanley Rd, Clayton, MO
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Collinsville Commercial Space For Lease
    $5,000/Mo
    5,000 SF

    Collinsville Commercial Space For Lease

    Versatile commercial space in Collinsville, available immediately.

    1902 Vandalia Street, Collinsville, IL 62234
    View details
    Cleared Lot in St Clair
    $1.00 SF/Yr

    Cleared Lot in St Clair

    1.5-acre cleared lot zoned for general commercial use.

    Saint Clair, MO 63077
    View details
    High-Traffic Commercial Land in Rolla
    $7,500/Mo

    High-Traffic Commercial Land in Rolla

    0.61 acre commercial land in high-traffic area for lease.

    704 N Bishop Avenue, Rolla, MO 65401
    View details
    Bentonville Land Lease Opportunity
    $1,000/Mo

    Bentonville Land Lease Opportunity

    4 acres for lease, build-to-suit near XNA Airport.

    2396 1st Avenue, Bentonville, AR 72713
    View details

    Clayton, MO Office buildings Leasing Opportunities Market Analysis

    Explore Office buildings leasing options in Clayton, MO with 7 listings featured on our commercial real estate exchange. The current inventory includes 112,493 square feet of properties with an estimated lease value of $167 SF/Yr.

    Estimated lease rates for Office buildings in Clayton, MO begin at $21 SF/Yr, with an average of $33 SF/Yr and extend to $42 SF/Yr.
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