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    Clayton, MO
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    Clayton, MO Office Buildings for Lease

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    Renovated Office Space in Clayton
    Updated: Nov 22, 2025
    Renovated Office Space in Clayton

    200 South Hanley Road, Clayton, MO 63105

    $18 SF/Yr
    30,210 sqft
    Convenient Clayton location with outstanding visibility
    Newly renovated building lobby, entrance, elevator cabs, and common areas (2022)
    Easy access to Forest Park Parkway
    Walking distance to numerous restaurants, retail, and hotels
    Garage and surface parking available
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    Downtown Clayton Office Building
    Updated: Nov 25, 2025
    Downtown Clayton Office Building

    225-235 S Meramec Ave, Clayton, MO 63105

    $21.50 SF/Yr
    102,600 sqft
    Prime Downtown Clayton location with high visibility and close proximity to the Courthouse.
    Enjoy on‑site amenities including management, post office, cafe, and common space.
    Abundant parking with a 1,200‑space garage and street parking.
    Newly built‑out spaces with high‑end finishes.
    Brand new lobby and updated common areas.
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    Class A Office Tower Clayton
    Class A Office Tower Clayton

    8182 Maryland Ave, Clayton, MO

    $35 SF/Yr
    4,086 sqft

    Class A office tower in downtown Clayton for lease.

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    Downtown Clayton Office Space Available
    Downtown Clayton Office Space Available

    225-235 S Meramec Ave, Clayton, MO 63105

    $21.50 SF/Yr
    102,600 sqft

    Two interconnected office buildings with on-site amenities and parking.

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    Based on your search, we've compiled 12 Potential Opportunities for your consideration. Besides 4 Active listings in Clayton, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

    Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Luxury Clayton Mid-Rise Office Building
    Luxury Clayton Mid-Rise Office Building

    7800 Forsyth Blvd, Saint Louis, MO

    $29.50 SF/Yr
    7,033 sqft

    Luxury office building in Clayton, close to amenities and courthouse.

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    Mixed-Use Center Office Space
    Mixed-Use Center Office Space

    1114 S Brentwood Blvd, Saint Louis, MO 63117

    Contact for pricing
    15,000 sqft

    Office space available in mixed-use lifestyle center with amenities.

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    Remodeled Corporate Center For Rent
    Remodeled Corporate Center For Rent

    7700-7750 Clayton Road, Richmond Heights, MO 63117

    $23 SF/Yr

    Newly remodeled corporate center with covered parking and outdoor patio.

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    Office Space in Clayton CBD
    Office Space in Clayton CBD

    Saint Louis, MO 63105

    $29.50 SF/Yr

    Office building with tenant amenities and convenient transportation access.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Class A Office Suite with Bullpen
    Class A Office Suite with Bullpen

    1902 Vandalia Street, Collinsville, IL 62234

    $5,000/Mo

    Recently built office space with private offices, bullpen, and modern amenities for professional teams.

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    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft

    2.43 acres for office development with build-to-suit opportunity.

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    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    1.7 acre corner lot zoned for commercial, medical, residential.

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    Build-to-Suit Commercial Land Parcel
    Build-to-Suit Commercial Land Parcel

    315 E Superior Street, Alma, MI 48801

    Contact for pricing

    Up to 0.34 acres of commercially zoned land for a customized build-to-suit in downtown Alma.

    View details

    Clayton, MO Office buildings Market Trends and Statistics

    Explore Office buildings leasing options in Clayton, MO with 4 listings featured on our commercial real estate exchange. The current inventory includes 239,496 square feet of properties with an estimated lease value of $96 SF/Yr.

    Estimated lease rates for Office buildings in Clayton, MO begin at $18 SF/Yr, with an average of $24 SF/Yr and extend to $35 SF/Yr.
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