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    Clayton, MO Office Units for Lease

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    University City, MO Saint Louis, MO Richmond Heights, MO
    30 results
    Clayton Office Space Available Now
    $30 SF/Yr
    4,288 SF
    Clayton Office Space Available Now

    231 S Bemiston Ave, Clayton, MO

    Former law firm space with elevator exposure and tenant amenities.
    • Prime location: Very short walking distance from the Clayton Metrolink and easy access to Forest Park Parkway and Interstate 170.
    • Tenant‑exclusive amenities: Includes a bike room, fitness center, lockers, and showers.
    • On‑site conveniences: Features an on‑site café, grab‑n‑go, and tenant lounge.
    • Ample office space: Offers nine private offices, two conference rooms, a break room, and a work room.
    • Attached parking garage: Includes a five‑level garage with an automated access system.
    Updated: Nov 23, 2025
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    Clayton Office Space For Rent
    $26 SF/Yr
    3,346 SF
    Clayton Office Space For Rent

    222 S Central Ave, Clayton, MO

    Eleven-story office building in Clayton with recent renovations.
    • Newly renovated building with refinished lobby, conference center, and tenant fitness center.
    • Prime location in the heart of Clayton.
    • Convenient access to Forest Park Parkway and Metrolink.
    • Close proximity to courthouses, restaurants, and hotels.
    • 11‑story building.
    Updated: Nov 24, 2025
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    Downtown Clayton Office Space Available
    $29 SF/Yr
    1,737 SF
    Downtown Clayton Office Space Available

    Office space for lease in downtown Clayton with amenities.

    150 N Meramec Ave, Clayton, MO

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    Clayton Office Space For Rent
    $14 SF/Yr
    350 SF
    Clayton Office Space For Rent

    Office spaces in the heart of Clayton near I-170 & I-64/40.

    30-44 N Brentwood Blvd, Clayton, MO

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    Downtown Clayton Office Space Available
    $29 SF/Yr
    2,372 SF
    Downtown Clayton Office Space Available

    Office space for rent in downtown Clayton, Missouri.

    165 N Meramec Ave, Clayton, MO

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    Professionally Managed Office Space Available
    $25 SF/Yr
    2,709 SF
    Professionally Managed Office Space Available

    Office space for lease with covered parking and convenient location.

    8151 Clayton Rd, Clayton, MO

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    Clayton CBD Office Space
    $32 SF/Yr
    1,464 SF
    Clayton CBD Office Space

    Move-in ready office suites in central Clayton location.

    7777 Bonhomme Ave, Clayton, MO

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    Upscale Office Space Available
    $30 SF/Yr
    6,125 SF
    Upscale Office Space Available

    Premium office space with amenities in Clayton, Missouri.

    8000 Maryland Ave, Clayton, MO

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    Renovated Office Space in Clayton
    $26 SF/Yr
    Renovated Office Space in Clayton

    Multiple office suites available in Clayton with renovated common areas.

    7711 Bonhomme Avenue, Clayton, MO 63105

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    Clayton Office Space Available
    $33 SF/Yr
    20,019 SF
    Clayton Office Space Available

    20,019 square foot office space for lease.

    101 South Hanley Road, Clayton, MO 63105

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    Clayton Office Space For Rent
    $31 SF/Yr
    45,777 SF
    Clayton Office Space For Rent

    Office space available in Clayton, Missouri with multiple amenities.

    7701 Forsyth Blvd, Clayton, MO

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    Clayton Office Space For Rent
    $31 SF/Yr
    39,547 SF
    Clayton Office Space For Rent

    Office space available with conferencing center and fitness center.

    7733 Forsyth Blvd, Clayton, MO

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    Downtown Clayton Office Space Available
    $28 SF/Yr
    10,007 SF
    Downtown Clayton Office Space Available

    Office space in downtown Clayton with convenient access and amenities.

    168 N Meramec Ave, Clayton, MO

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    Clayton Office Space For Rent
    $43 SF/Yr
    Clayton Office Space For Rent

    Office space available for lease in Clayton, Missouri.

    190 Carondelet Plaza, Clayton, MO 63105

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    Clayton Office Space For Rent
    $26 SF/Yr
    Clayton Office Space For Rent

    Office space available for lease in Clayton, Missouri.

    222 South Central Avenue, Clayton, MO 63105

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    Clayton Office Space Available
    $24 SF/Yr
    3,270 SF
    Clayton Office Space Available

    Office space available for lease in Clayton, Missouri.

    8251 Maryland Ave, Clayton, MO

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    Renovated Office Space in Clayton
    $26 SF/Yr
    1,993 SF
    Renovated Office Space in Clayton

    Multiple suites available in a recently renovated building.

    7711 Bonhomme Ave, Clayton, MO

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    Clayton Office Space For Rent
    $24 SF/Yr
    3,305 SF
    Clayton Office Space For Rent

    3,305 SF office space available in Clayton, Missouri.

    8301 Maryland Ave, Clayton, MO

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    Clayton Office Space For Rent
    $15 SF/Yr
    7,441 SF
    Clayton Office Space For Rent

    7,441 square foot office space available for lease.

    135 N Meramec Ave, Clayton, MO

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    Clayton Office Space For Rent
    $32 SF/Yr
    4,494 SF
    Clayton Office Space For Rent

    Office space for rent in Clayton, Missouri.

    120 S Central Ave, Clayton, MO

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    Class A Office Space Available
    $45 SF/Yr
    27,666 SF
    Class A Office Space Available

    High-end office space with many amenities and ample parking.

    7700 Forsyth Blvd, Clayton, MO

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    High-End Office Space Available
    $21 SF/Yr
    1,188 SF
    High-End Office Space Available

    Newly built-out office spaces with updated common areas.

    225-235 S Meramec Ave, Clayton, MO

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    Downtown Clayton Office Space Available
    $24 SF/Yr
    4,500 SF
    Downtown Clayton Office Space Available

    Office space for rent in downtown Clayton near amenities.

    7808-7810 Forsyth Blvd, Clayton, MO

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    Downtown Clayton Office Space
    $1,400/Mo
    680 SF
    Downtown Clayton Office Space

    Office space for rent in downtown Clayton, Missouri.

    7800 Bonhomme Ave, Clayton, MO

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    Clayton, MO Office Units Leasing Opportunities Market Analysis

    Explore Office Units leasing options in Clayton, MO with 30 listings featured on our commercial real estate exchange. The current inventory includes 252,175 square feet of properties with an estimated lease value of $692 /Mo.

    Estimated lease rates for Office Units in Clayton, MO begin at $14 SF/Yr, with an average of $27 SF/Yr and extend to $45 SF/Yr.
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    Most Searched ZIP Codes in Clayton, MO

    • 63105
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