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    Clayton, MO Office Units for Lease

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    20 properties
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    Downtown Clayton Office Space Available
    Updated: Nov 24, 2025
    Downtown Clayton Office Space Available

    150 N Meramec Ave, Clayton, MO

    $29 SF/Yr
    1,737 sqft
    Downtown Clayton Location with Easy I‑170 Access
    Free Visitor Parking plus Covered Tenant Garage Parking
    Amenities Include Fitness Center & Express Food Market
    Building Signage Opportunity
    Common Area & Lobby Renovations Completed
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    Clayton Office Space For Rent
    Updated: Aug 18, 2025
    Clayton Office Space For Rent

    30-44 N Brentwood Blvd, Clayton, MO

    $14 SF/Yr
    350 sqft
    Prime location in the heart of Clayton.
    Allocated parking in attached garage.
    Additional structured parking adjacent to building.
    Walking distance to shops and restaurants.
    Convenient access to I‑170 & I‑64/40.
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    Clayton Office Space For Rent
    Clayton Office Space For Rent

    7701 Forsyth Blvd, Clayton, MO

    $31 SF/Yr
    45,777 sqft

    Office space available in Clayton, Missouri with multiple amenities.

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    Clayton Office Space For Rent
    Clayton Office Space For Rent

    7733 Forsyth Blvd, Clayton, MO

    $31 SF/Yr
    39,547 sqft

    Office space available with conferencing center and fitness center.

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    Clayton CBD Office Space
    Clayton CBD Office Space

    7777 Bonhomme Ave, Clayton, MO

    $31 SF/Yr
    1,464 sqft

    Move-in ready office suites in central Clayton location.

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    Clayton Office Space Available
    Clayton Office Space Available

    101 South Hanley Road, Clayton, MO 63105

    $33.50 SF/Yr
    20,019 sqft

    20,019 square foot office space for lease.

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    Downtown Clayton Office Space Available
    Downtown Clayton Office Space Available

    168 N Meramec Ave, Clayton, MO

    $29 SF/Yr
    10,007 sqft

    Office space in downtown Clayton with convenient access and amenities.

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    Clayton Office Space Available
    Clayton Office Space Available

    8251 Maryland Ave, Clayton, MO

    $24.50 SF/Yr
    3,270 sqft

    Office space available for lease in Clayton, Missouri.

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    Renovated Office Space in Clayton
    Renovated Office Space in Clayton

    7711 Bonhomme Avenue, Clayton, MO 63105

    $26.50 SF/Yr

    Multiple office suites available in Clayton with renovated common areas.

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    Clayton Office Space For Rent
    Clayton Office Space For Rent

    190 Carondelet Plaza, Clayton, MO 63105

    $43.50 SF/Yr

    Office space available for lease in Clayton, Missouri.

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    Clayton Office Space For Rent
    Clayton Office Space For Rent

    222 South Central Avenue, Clayton, MO 63105

    $26.50 SF/Yr

    Office space available for lease in Clayton, Missouri.

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    Clayton Office Space For Rent
    Clayton Office Space For Rent

    135 N Meramec Ave, Clayton, MO

    $31 SF/Yr
    7,441 sqft

    7,441 square foot office space available for lease.

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    High-End Office Space Available
    High-End Office Space Available

    225-235 S Meramec Ave, Clayton, MO

    $21.50 SF/Yr
    1,188 sqft

    Newly built-out office spaces with updated common areas.

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    Clayton Office Space For Rent
    Clayton Office Space For Rent

    120 S Central Ave, Clayton, MO

    $33 SF/Yr
    4,494 sqft

    Office space for rent in Clayton, Missouri.

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    Downtown Clayton Office Space Available
    Downtown Clayton Office Space Available

    7808-7810 Forsyth Blvd, Clayton, MO

    $24 SF/Yr
    4,500 sqft

    Office space for rent in downtown Clayton near amenities.

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    Upscale Office Space Available
    Upscale Office Space Available

    8000 Maryland Ave, Clayton, MO

    $30 SF/Yr
    6,125 sqft

    Premium office space with amenities in Clayton, Missouri.

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    Professionally Managed Office Space Available
    Professionally Managed Office Space Available

    8151 Clayton Rd, Clayton, MO

    $25 SF/Yr
    2,709 sqft

    Office space for lease with covered parking and convenient location.

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    Downtown Clayton Office Space
    Downtown Clayton Office Space

    7800 Bonhomme Ave, Clayton, MO

    $1,400/Mo
    680 sqft

    Office space for rent in downtown Clayton, Missouri.

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    Class A Office Tower Clayton
    Class A Office Tower Clayton

    101 S Hanley Rd, Clayton, MO

    $33.50 SF/Yr
    1,861 sqft

    Modern office space with comprehensive amenities in Clayton, Missouri.

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    Usable Office Space Available
    Usable Office Space Available

    7801 Clayton Rd, Clayton, MO 63117

    Contact for pricing
    1,658 sqft

    1,658 SF office space with excellent Clayton Road visibility.

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    Based on your search, we've compiled 20 Potential Opportunities for your consideration.

    Clayton, MO Office Units Market Trends and Statistics

    Explore Office Units leasing options in Clayton, MO with 20 listings featured on our commercial real estate exchange. The current inventory includes 151,169 square feet of properties with an estimated lease value of $445.71 /Mo.

    Estimated lease rates for Office Units in Clayton, MO begin at $14 SF/Yr, with an average of $27.86 SF/Yr and extend to $33.50 SF/Yr.
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