Missouri Office buildings for Rent & Lease

Updated: Jul 11

Renovated Downtown Storefront Property

230 N Sprigg Street, Cape Girardeau, MO 63701

$2,500/Mo

2,937 sqft 0.25 AC lot

2937 square feet of renovated commercial space
Renovations include A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and tuckpointing
Brick construction with a flat roof
Forced‑air heating and central air with electric cooling
Open parking lot and road frontage on N Sprigg Street

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Updated: Aug 24

Flexible Office Building

604 Industrial Park Drive, Eldon, MO 65026

$3,000/Mo

6,000+/- SF office building on a full acre
Parking for 50+ vehicles
Industrial zoning with office, medical, institutional, and other commercial use potential
Two‑section layout with separate entrances for each side
Three bathrooms, private offices, bullpen areas, reception space, and kitchen

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Renovated Stand-Alone Office Building

307 E 23rd Street, Independence, MO 64055

$2,485/Mo

0.20 AC lot

C-2 space includes work areas, a break room, restrooms, and lower-level storage.

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Two-Level Office Suite with Parking

222 E Water St, Springfield, MO 65806

$14.50 SF/Yr

5,240 sqft

Flexible two-level layout with executive offices, conference space, and abundant natural light plus ample private parking.

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Brick Office Building with Central Air

162 Missouri Boulevard, Laurie, MO 65038

$2,000/Mo

4.00 AC lot

Office space with private offices, open work area, and reception, supported by central air and public utilities.

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Flexible Office Units with Parking

1602 N Woodbine Road, St Joseph, MO 64506

$14 SF/Yr

1.43 AC lot

Office property offering single-tenant or multi-suite leasing configurations with C-3 zoning and on-site parking.

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Medical Office Building

6944 N Hanley Road, Hazelwood, MO 63042

$5,000/Mo

2.28 AC lot

Former bank building adapted for medical office use with flexible interior spaces.

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Brick Office Building with Parking

144 Scott Station Rd, Jefferson City, MO 65109

$5,000/Mo

4,707 sqft

Office property with on-site parking, storage areas, and a rear yard near retail, lodging, dining, and Hwy. 50.

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Updated Freestanding Office Building

1759 E Elm Street, Springfield, MO 65802

$2,500/Mo

0.41 AC lot

Flexible layout with private offices, conference rooms, two bathrooms, kitchenette, and reception space.

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Downtown Office Building with Elevator

202 S Kingshighway Street, Sikeston, MO 63801

$4,500/Mo

0.34 AC lot

Downtown Sikeston office building on a corner lot with central air, parking for 15, and elevator access to the basement.

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Office Space Near I-70

190 Spring Drive, Saint Charles, MO 63303

$12 SF/Yr

7,584 sqft

7,584 SF office space with convenient highway access.

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Professional Office Building with Private Offices

590 W Pacific Street, Branson, MO 65616

$699,900/Mo

0.30 AC lot

Flexible office layout with multiple entrances, two HVAC systems, signage, and on-site parking.

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Hi-Low Office/Retail Suites

850 Haines Drive, Liberty, MO 64068

$1.00 SF/Yr

Under-construction office suites in Oakwood Business Park with water service, on-level parking, and fiber available.

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Office Space

120 W 72 St, Kansas City, MO 64114

$2,442/Mo

4,884 sqft

Office space is available for lease at 120 W 72 St in Kansas City’s Waldo area.

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Creative Office Space with Roll-Up Door

225 E Pacific Street, Springfield, MO 65803

$2,800/Mo

0.26 AC lot

Renovated freestanding workspace with central air, private meeting capacity, on-site parking, and a finished kitchen area.

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Brick Live-Work Building

1348 E Cherry Street, Springfield, MO 65802

$2,500/Mo

0.47 AC lot

Two-level property combines office areas, a kitchen, unfinished basement space, and outdoor areas for meetings or gatherings.

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Downtown Office Building For Lease

18 N. Main, Cape Girardeau, MO 63701

$8,558/Mo

13,694 sqft

13,694 SF office building in historic downtown Cape Girardeau.

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Drive-Through Office Building

30667 State Highway 413, Galena, MO 65656

$11 SF/Yr

0.94 AC lot

Standalone office property with private offices, kitchen space, and a gross lease structure.

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White-Box Office Building

2929 North Eastgate Avenue, Springfield, MO 65803

$20 SF/Yr

16,946 sqft

Flexible full-building or single-floor configurations support office users and permitted industrial applications.

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Single-Story Office Building

1702 Buckingham Street, St Joseph, MO 64506

$12 SF/Yr

1.39 AC lot

C-3-zoned standalone property with dedicated parking and a layout suited to office, medical, administrative, or service-based operations.

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Class A Office Space

100 N Broadway, St., Louis, MO 63102

$215 SF/Yr

340,419 sqft

Contiguous leasing options support a range of tenant sizes within a downtown office tower.

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Brick Office Building with Highway Frontage

2720 Shepherd of the Hills Expwy, Branson, MO 65616

$10 SF/Yr

41,360 sqft 4.34 AC lot

Main and lower levels provide office, retail, or professional space on a high-traffic highway corridor.

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Central Business District Office Building

901 Locust Street, Kansas City, MO 64106

$32 SF/Yr

204,607 sqft

Large office property positioned among government offices, corporate headquarters, and residential redevelopment in Kansas City’s East Village.

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Office Campus with Ample Parking

4802 Mitchell Avenue, St Joseph, MO 64507

$24 SF/Yr

27.66 AC lot

Modern office campus offering ample parking and flexible floor plan options for businesses seeking a dedicated work environment.

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Missouri Office buildings Market Trends and Statistics

Explore Office buildings leasing options in Missouri with 256 listings featured on our commercial real estate exchange. The current inventory includes 6,641,010 square feet of properties with an estimated lease value of $940.46.

Estimated lease rates for Office buildings in Missouri begin at $6 SF/Yr, with an average of $24.11 SF/Yr and extend to $215 SF/Yr.