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    South Portland, ME Office Buildings for Lease

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    Class A Office Space Available
    Contact for pricing

    Class A Office Space Available

    778 Main St, South Portland, ME 04106

    Class A office building with ample parking and professional landscaping.

    • Prime location on Route One, minutes from Portland, Maine Mall, and Portland Jetport.
    • Easy access to Maine Turnpike and I‑295.
    • Ample parking and professional landscaping.
    • Class A office building.
    • Join esteemed tenants like Boston IVF and Health Markets.
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    Class A Office/Medical Building
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    5,530 SF

    Class A Office/Medical Building

    175 Running Hill Rd, South Portland, ME 04106

    Class A office/medical building with suites available for lease.

    • Class A office/medical building with suites available, ranging from 4,646 to 8,542± SF.
    • Central location with easy access to Maine Turnpike/I‑95 and I‑295.
    • Conveniently located near Portland International Jetport, hotels, and restaurants.
    • Professionally managed property situated on 13.09± acres.
    • Ample paved parking available.
    Updated: Jul 29, 2025
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    75 John Roberts Road Office Space
    $14 SF/Yr
    36,972 SF

    75 John Roberts Road Office Space

    Class A Office, 8,114 SF Available

    75 John Roberts Rd, South Portland, ME 04106
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    Class A Office Space Available
    Contact for pricing
    104,752 SF

    Class A Office Space Available

    Class A office space for lease in South Portland.

    2 Gannett Dr, South Portland, ME 04106
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    Based on your search, we've compiled 8 Potential Opportunities for your consideration. Besides 4 Active listings in South Portland, ME, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

    Explore Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Freestanding Office Building in Portland
    Contact for pricing
    38,227 SF

    Freestanding Office Building in Portland

    Professional office building in wooded campus setting for lease.

    41 Hutchins Dr, Portland, ME 04102
    View details
    Class A Office Building For Lease
    Contact for pricing
    13,878 SF

    Class A Office Building For Lease

    Premier office building with amenities near transportation and retail.

    2211 Congress St, Portland, ME 04102
    View details
    Lewiston Downtown Investment Opportunity
    $680 / Mo
    1,000 SF

    Lewiston Downtown Investment Opportunity

    Downtown Lewiston office building with steady cash flow.

    183 Main St, Lewiston, ME 04240
    View details
    Lewiston Office Building For Sale
    Contact for pricing
    60,120 SF

    Lewiston Office Building For Sale

    60,120± SF office building on 5.97± AC available.

    17-19 Mollison Way, Lewiston, ME 04240
    View details

    South Portland, ME Office buildings Leasing Opportunities Market Analysis

    Explore Office buildings leasing options in South Portland, ME with 4 listings featured on our commercial real estate exchange. The current inventory includes 1,610,500,320 square feet of properties with an estimated lease value of $14 SF/Yr.

    Estimated lease rates for Office buildings in South Portland, ME begin at $14 SF/Yr, with an average of $14 SF/Yr and extend to $14 SF/Yr.
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    Most Searched ZIP Codes in South Portland, ME

    • 04106

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