Add Listing
    San Luis Obispo, CA
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent
    $
    $
    Size
    Property Size / SF

    San Luis Obispo, CA Medical Office Space for Lease

    Notify Me
    List
    Map
    10 results
    Remodeled Office Suite For Rent
    $2,250/Mo
    930 SF

    Remodeled Office Suite For Rent

    1250 Peach St, San Luis Obispo, CA

    Remodeled office suite with mountain views in Fremont Medical Center.

    • Remodeled suite in the coveted Fremont Medical Center
    • Two offices with separate entrances
    • Deck with views of San Luis Mountain
    • Kitchenette and bathroom included
    • Ample parking available
    Updated: Sep 29, 2025
    View details
    Freestanding Building with Parking Spaces
    Contact for pricing

    Freestanding Building with Parking Spaces

    3565 S Higuera, San Luis Obispo, CA 93401

    Freestanding building with efficient layout, parking, and prominent signage.

    • Freestanding building with an efficient layout
    • Ten on‑site parking spaces
    • Excellent ingress and egress from South Higuera frontage road
    • Large monument sign on the street for prominent signage
    • Generous reception area
    Updated: Apr 24
    View details
    Medical Office Near Sierra Vista
    $3 SF/Yr
    1,300 SF

    Medical Office Near Sierra Vista

    Ground floor medical office space available near Sierra Vista Hospital.

    100 Casa St, San Luis Obispo, CA
    View details
    Downtown San Luis Obispo Office Space
    $1.05 SF/Yr

    Downtown San Luis Obispo Office Space

    First floor office suite suitable for medical or professional use.

    990 Pacific Street |, San Luis Obispo, CA 93401
    View details
    Turn Key Medical Suite
    Contact for pricing

    Turn Key Medical Suite

    Medical suite with exam rooms, physician's office, and nurse's station.

    628 California Blvd D-1, San Luis Obispo, CA 93401
    View details
    Class A Office Space Available
    $1.85 SF/Yr
    7,197 SF

    Class A Office Space Available

    Ground floor office suite with upgraded finishes and private patios.

    895 Aerovista Pl, San Luis Obispo, CA
    View details
    Renovated Medical/Dental Office Space
    $2 SF/Yr
    1,010 SF

    Renovated Medical/Dental Office Space

    Recently renovated medical/dental office space available for immediate occupancy.

    1223 Higuera St, San Luis Obispo, CA
    View details
    1288 Morro St, Suite 100
    $1.85 SF/Yr

    1288 Morro St, Suite 100

    Medical Office | San Luis Obispo, CA

    1288 Morro Street, Suite 100 | San Luis Obispo, CA 93401, San Luis Obispo, CA 93401
    View details
    1288 Morro St, Suite 100
    $1.85 SF/Yr

    1288 Morro St, Suite 100

    Medical Office | San Luis Obispo, CA

    1288 Morro Street, Suite 100 | San Luis Obispo, CA 93401, San Luis Obispo, CA 93401
    View details
    Prime Commercial Parcels for Lease
    Contact for pricing

    Prime Commercial Parcels for Lease

    Six improved parcels available for lease in San Luis Obispo.

    250 Tank Farm Rd, San Luis Obispo, CA 93401
    View details
    Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 10 Active listings in San Luis Obispo, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 1 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Ground Floor Medical Office Space
    Contact for pricing
    2,164 SF

    Ground Floor Medical Office Space

    2164 SF office space available 8/1/2026.

    880 N Oak Park Blvd 103, Arroyo Grande, CA 93420
    View details
    Medical Office Space Available
    $2 SF/Yr
    1,877 SF

    Medical Office Space Available

    Medical office condo for rent in established medical hub.

    325 Posada Ln, Templeton, CA
    View details
    Arroyo Grande Office Space Available
    $1.75 SF/Yr
    1,748 SF

    Arroyo Grande Office Space Available

    Office suite with exam rooms, private restroom, and patio.

    200 Station Way, Arroyo Grande, CA
    View details
    Medical Office Condo Near Hospital
    Contact for pricing
    1,272 SF

    Medical Office Condo Near Hospital

    Medical office condo for lease near Twin Cities Hospital.

    1105 Las Tablas Road, Templeton, CA 93465
    View details

    Similar Spaces for Sale in San Luis Obispo, CA

    Consider Similar Space for Sale. We found 1 Spaces matching your search parameters.

    Mixed-Use Commercial Property Near Courthouse
    $1,395,000
    Mixed-Use Commercial Property Near Courthouse

    Mixed-use commercial property with flexible office space and on-site parking.

    1022 Mill St, San Luis Obispo, CA 93401

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Grand Junction Commercial Land Lease
    $9,656/Mo

    Grand Junction Commercial Land Lease

    0.74 acre commercial land for lease in Grand Junction.

    Highway 6&50, Grand Junction, CO 81505
    View details
    Grand Junction Commercial Land Opportunity
    $17,728/Mo

    Grand Junction Commercial Land Opportunity

    1.36 acre commercial land for lease in Grand Junction.

    Sanford Drive, Grand Junction, CO 81505
    View details
    El Paso Commercial Land Lease
    $3,600/Mo

    El Paso Commercial Land Lease

    Commercial land for lease in a strategic El Paso location.

    5538 E Paisano Drive, El Paso, TX 79905
    View details
    Corner Lot on Highway 72
    $5,000/Mo
    1,875 SF

    Corner Lot on Highway 72

    1.7 acre corner lot zoned for commercial, medical, residential.

    30472 Highway 72, Madison, AL 35756
    View details

    San Luis Obispo, CA Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in San Luis Obispo, CA with 10 listings featured on our commercial real estate exchange. The current inventory includes 10,462 square feet of properties with an estimated lease value of $37 SF/Yr.

    Estimated lease rates for Medical Office Space in San Luis Obispo, CA begin at $1.05 SF/Yr, with an average of $7 SF/Yr and extend to $29 SF/Yr.
    List
    Map

    Browse Medical Office Space for Lease Near San Luis Obispo, CA

    Popular Searches in San Luis Obispo, CA

    Popular Categories

    Most Searched ZIP Codes in San Luis Obispo, CA

    • 93401

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!