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Sioux Falls, SD Medical Office Space for Sale

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Sioux Falls Adaptable Commercial Building
$2,250,379
49,424 SF

Sioux Falls Adaptable Commercial Building

4800 N 4th Ave, Sioux Falls, SD 57104

49,424 SF vacant building suitable for daycare, medical, or office.

  • Large Vacant Space: 49,424 SF
  • Suitable for Daycare, Medical, or Office Use
  • Ample Parking: 104 Spaces
  • Sprinkler System: Wet
  • Dock Door: 1
Updated: Jan 27
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Sioux Falls Medical Office
$1,400,000
6,858 SF

Sioux Falls Medical Office

208 W 37th St, Sioux Falls, SD

Medical office building with exam rooms and updated infrastructure.

  • Large main level (4,743 SF) with 11 exam rooms suitable for medical practice.
  • New parking lot (2023).
  • Lower level (1,349 SF) with locker room, restroom with shower, meeting room, laundry and storage.
  • X‑ray room.
  • Two private offices.
Updated: Mar 21, 2025
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Sioux Falls Office/Medical Building
$1,980,000
9,288 SF

Sioux Falls Office/Medical Building

Office/medical building with flexible space and ample parking.

4904-4912 S Minnesota Ave, Sioux Falls, SD
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Based on your search, we've compiled 118 Potential Opportunities for your consideration. Besides 3 Active listings in Sioux Falls, SD, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 107 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Dakota Dunes Office Condo
$450,000
2,800 SF

Dakota Dunes Office Condo

2,800 SF office condo in Dakota Dunes, South Dakota.

383 W Steamboat Dr, Ste 201, Dakota Dunes, SD 57049
View details
Professional Building with Exam Rooms
Contact for pricing
1,994 SF

Professional Building with Exam Rooms

Professional building featuring multiple exam rooms and office spaces.

2912 Hamilton Blvd 103, Sioux City, IA 51104
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Downtown Office Space Available
Contact for pricing
13,723 SF

Downtown Office Space Available

Centrally located office space with parking and modern amenities.

700 4th Street, Sioux City, IA, Sioux City, IA 51101
View details
Dakota Dunes Office Condo
$450,000
2,800 SF

Dakota Dunes Office Condo

2,800 SF office condo, currently a dental office.

383 W Steamboat Dr, Dakota Dunes, SD 57049
View details

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Lot in Growing Tea
$220,000
0.68 Acres

Commercial Lot in Growing Tea

High-visibility commercial lot in a high-growth Sioux Falls metro area.

500 N Heritage Pkwy, Tea, SD 57064
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Mankato Commercial Land For Sale
$165,000
1.08 Acres

Mankato Commercial Land For Sale

Accessible 1.08-acre lot suitable for various business types.

1763 Bassett Drive, Mankato, MN 56001
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Commercial Lot in Medical Area
$299,900
1.06 Acres

Commercial Lot in Medical Area

Prime commercial lot near medical facilities and recreational centers.

2030 Stearns Way, Saint Cloud, MN 56303
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Two-Acre Commercial Land in Otsego
$319,900
2.00 Acres

Two-Acre Commercial Land in Otsego

Two-acre commercial land in fast-growing Otsego, prime for development.

Xxx Quaday Ave Ne, Otsego, MN 55330
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Explore Off-Market Properties in Sioux Falls, SD

Consider similar Off-Market properties in Sioux Falls, SD. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

6301 41st St

6301 41st St

MEDICAL BUILDING • 3,108 SF
Value Estimation
$2,000,000
6301 41st St, Sioux Falls, SD 57106-1217
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101 37th St

101 37th St

DENTAL BUILDING • 11,259 SF
Value Estimation by Request
101 37th St, Sioux Falls, SD 57105-5701
View details
2600 Western Ave

2600 Western Ave

DENTAL BUILDING • 2,948 SF
Value Estimation by Request
2600 Western Ave, Sioux Falls, SD 57105-4429
View details
2301 Lorraine Pl

2301 Lorraine Pl

DENTAL BUILDING • 1.66 Acres
Value Estimation by Request
2301 Lorraine Pl, Sioux Falls, SD 57106-3642
View details
1700 Southeastern Ave

1700 Southeastern Ave

DENTAL BUILDING • 12,664 SF
Value Estimation
$610,000
1700 Southeastern Ave, Sioux Falls, SD 57103-3227
View details
2300 Westlake Dr

2300 Westlake Dr

DENTAL BUILDING • 10,612 SF
Value Estimation by Request
2300 Westlake Dr, Sioux Falls, SD 57106-8527
View details
3805 Kiwanis Cir

3805 Kiwanis Cir

MEDICAL BUILDING • 4,686 SF
Value Estimation
$900,000
3805 Kiwanis Cir, Sioux Falls, SD 57105-4266
View details
1710 Southeastern Ave

1710 Southeastern Ave

DENTAL BUILDING • 3,929 SF
Value Estimation
$800,000
1710 Southeastern Ave, Sioux Falls, SD 57103-3381
View details
2521 Western Ave

2521 Western Ave

DENTAL BUILDING • 2,146 SF
Value Estimation by Request
2521 Western Ave, Sioux Falls, SD 57105-3430
View details
4001 Southeastern Ave

4001 Southeastern Ave

DENTAL BUILDING • 3,236 SF
Value Estimation by Request
4001 Southeastern Ave, Sioux Falls, SD 57103-5305
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Sioux Falls, SD 57106

Sioux Falls, SD 57106

DENTAL BUILDING • 8.27 Acres
Value Estimation by Request
Sioux Falls, SD 57106
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4601 Homefield Dr

4601 Homefield Dr

DENTAL BUILDING • 13,064 SF
Value Estimation
$640,000
4601 Homefield Dr, Sioux Falls, SD 57106-3506
View details
3401 Kelley Ave

3401 Kelley Ave

MEDICAL BUILDING • 4,376 SF
Value Estimation by Request
3401 Kelley Ave, Sioux Falls, SD 57106-6300
View details
518 Sycamore Ave

518 Sycamore Ave

DENTAL BUILDING • 2,500 SF
Value Estimation by Request
518 Sycamore Ave, Sioux Falls, SD 57110-5737
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2100 Marion Rd

2100 Marion Rd

MEDICAL BUILDING • 86,566 SF
Value Estimation
$8,590,000
2100 Marion Rd, Sioux Falls, SD 57106-3646
View details
3400 26th St

3400 26th St

DENTAL BUILDING • 3,135 SF
Value Estimation by Request
3400 26th St, Sioux Falls, SD 57103-4183
View details
229 39th St Ste, Unit 100

229 39th St Ste, Unit 100

MEDICAL BUILDING • 3,420 SF
Value Estimation by Request
229 39th St Ste, Sioux Falls, SD 57105-5700
View details
1711 10th St

1711 10th St

DENTAL BUILDING • 4,320 SF
Value Estimation by Request
1711 10th St, Sioux Falls, SD 57103-1805
View details
202 37th St

202 37th St

MEDICAL BUILDING • 3,600 SF
Value Estimation by Request
202 37th St, Sioux Falls, SD 57105
View details
911 20th St

911 20th St

MEDICAL BUILDING • 81,404 SF
Value Estimation
$2,905,000
911 20th St, Sioux Falls, SD 57105-1042
View details
716 19th St

716 19th St

MEDICAL BUILDING • 11,390 SF
Value Estimation
$665,000
716 19th St, Sioux Falls, SD 57105-0904
View details

Sioux Falls, SD Medical Office Space Investment Opportunities Market Analysis

Explore 110 medical office space for sale in Sioux Falls, SD, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 1,557,412 square feet of properties for sale, with an estimated market value of $17,680,000.

Sale prices for medical spaces in Sioux Falls, SD start at $155,000, averaging $376,170, and reaching up to $2,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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