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    Durham, NC Medical Office Space for Lease

    10 results
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    Versatile Office/Medical Space Available
    $3,000 /Mo
    2,400 SF

    Versatile Office/Medical Space Available

    3925 N Duke Street unit: 121, Durham, NC 27704

    2400 sq ft office/medical suite in prime Durham location.

    • Prime Durham location, minutes from downtown and Duke Regional Hospital.
    • Versatile 2400 sq ft space suitable for office, medical, or service‑based businesses.
    • Five private offices plus open central workspace.
    • Previously configured for dental and salon use.
    • Large reception area ideal for client‑facing businesses.
    Updated: Feb 18
    View details
    Durham Medical/Office Building for Lease
    $23 SF/Yr
    4,769 SF

    Durham Medical/Office Building for Lease

    110 E. Carver Street, Durham, NC 27704

    Freestanding 4,769 SF building suitable for medical or office use.

    • Ideally situated near Duke Regional Hospital and I‑85 in north Durham.
    • Versatile ±4,769 SF building, formerly a medical office and surgery center, suitable for medical or professional office use.
    • Customizable space with landlord offering quick and cost‑effective reconfigurations.
    • Features a reception area, spacious waiting room, multiple exam rooms with sinks, private offices, and surgical rooms.
    • Convenient amenities including 18 on‑site parking spaces, prominent monument signage, and a backup generator.
    Updated: Nov 21, 2025
    View details
    Class A Office Space
    $23 SF/Yr
    79,440 SF

    Class A Office Space

    Class A office space for lease in North Durham.

    4321 Medical Park Dr, Durham, NC 27704
    View details
    Office/Medical Building Near Southpoint Mall
    $26 SF/Yr
    18,395 SF

    Office/Medical Building Near Southpoint Mall

    Single-story office/medical building near Southpoint Mall available for lease.

    5501 Fortunes Ridge Drive, Durham, NC 27713
    View details
    Roxboro Road Professional Office Space
    $20 SF/Yr
    2,408 SF

    Roxboro Road Professional Office Space

    Office space ideal for professional services and medical offices.

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704
    View details
    Medical Office Space in Durham
    Contact for pricing
    5,986 SF

    Medical Office Space in Durham

    Dental specialist office space for lease near Duke University/Hospital.

    1212 Broad Street, Suite B, Durham, NC 27705
    View details
    Prime Medical Office Space Available
    $18 SF/Yr
    2,312 SF

    Prime Medical Office Space Available

    Versatile medical/office space in Durham's thriving North Duke corridor.

    2609 N Duke Street unit: Bldg 300, Unit 302, Durham, NC 27704
    View details
    Medical Office Space Sublease
    Contact for pricing
    1,504 SF

    Medical Office Space Sublease

    Medical office space available for sublease.

    5015 Southpark Dr, Durham, NC 27713
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    Move-in Ready Office Suite
    $24 SF/Yr
    1,000 SF

    Move-in Ready Office Suite

    First-floor office suite in a high-demand Durham location.

    1804 Martin Luther King Jr Pkwy, Durham, NC 27707
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    Medical Office Space For Lease
    Contact for pricing

    Medical Office Space For Lease

    Second generation medical office space available for lease.

    4020 N Roxboro St, Durham, NC 27704
    View details
    Based on your search, we've compiled 23 Potential Opportunities for your consideration. Besides 10 Active listings in Durham, NC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

    Explore Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical Office Building Near Rex Hospital
    Contact for pricing
    21,332 SF

    Medical Office Building Near Rex Hospital

    Two-story medical office building near Rex Hospital campus.

    3921 Sunset Ridge Rd, Raleigh, NC 27607
    View details
    Retail, Medical, or Office Space
    Contact for pricing

    Retail, Medical, or Office Space

    First floor end unit suitable for retail, medical, or office.

    1200 Gathering Park Cir, Cary, NC 27519
    View details
    Medical Plaza at Rex
    Contact for pricing
    103,500 SF

    Medical Plaza at Rex

    Class A medical office building on Rex Hospital campus.

    4414 Lake Boone Trail, Raleigh, NC 27607
    View details
    Class A Medical Office Building
    Contact for pricing
    36,000 SF

    Class A Medical Office Building

    Three-story medical office building with variety of medical tenants.

    7560 Carpenter Fire Station Rd, Cary, NC 27519
    View details

    Explore Similar Spaces for Sale in Durham, NC

    Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

    Professional Office Condo Near Duke
    $385,000
    1,954 SF

    Professional Office Condo Near Duke

    Office condo in Croasdaile Office Park, convenient location.

    3200 Croasdaile Drive unit: 101 & 102, Durham, NC 27705
    View details
    Colonial Square Office/Medical Building
    $3,499,000
    21,532 SF

    Colonial Square Office/Medical Building

    Multi-functional commercial building in Durham's Independence Park.

    4400 Ben Franklin Boulevard, Durham, NC 27704
    View details
    Medical Office & Wellness Center
    Contact for pricing
    25,317 SF

    Medical Office & Wellness Center

    Medical office and wellness center in high-traffic Durham location.

    3017 Pickett Rd, Durham, NC 27705
    View details
    Durham Office Near Highway 85
    $750,000
    1,600 SF

    Durham Office Near Highway 85

    Office property close to Highway 85, Duke, and RTP.

    3219 Guess, Durham, NC 27705
    View details
    Renovated Medical Office Condos
    Contact for pricing
    41,588 SF

    Renovated Medical Office Condos

    Newly renovated medical office condos for sale in Durham, NC.

    4020 N Roxboro St, Durham, NC 27704
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Land in Upper St Clair
    $50,000

    Prime Land in Upper St Clair

    Commercial land for lease in Upper St Clair, PA.

    2585 Maple Lane, Upper St Clair, PA 15241
    View details
    Prime Commercial Lot For Rent
    $7,500 /Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
    View details
    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    0 Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
    View details
    Highway 72 Corner Lot
    $6,500 /Mo
    1,875 SF

    Highway 72 Corner Lot

    1.6 acre commercial lot for rent on Highway 72.

    30472 Highway 72, Madison, AL 35756
    View details

    Durham, NC Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Durham, NC with 10 listings featured on our commercial real estate exchange. The current inventory includes 1,111,433,400 square feet of properties with an estimated lease value of $79 SF/Yr.

    Estimated lease rates for Medical Office Space in Durham, NC begin at $15 SF/Yr, with an average of $19 SF/Yr and extend to $26 SF/Yr.
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    Popular Searches in Durham, NC

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    Most Searched ZIP Codes in Durham, NC

    • 27704
    • 27713
    • 27705
    • 27707

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