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    South Portland, ME Medical Office Space for Lease

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    South Portland Retail/Office Opportunity
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    11,890 SF

    South Portland Retail/Office Opportunity

    264 Gorham Rd, South Portland, ME 04106

    Modern, adaptable space in high-traffic Maine Mall area.

    • Prime location in the Maine Mall retail trade area with high visibility.
    • Easy access from I‑95 and I‑295.
    • Newer construction (built in 2019).
    • Adaptable space suitable for retail or traditional office uses.
    • Large pylon sign on Gorham Road.
    Updated: Sep 23, 2025
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    Class A Office/Medical Building
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    6,363 SF

    Class A Office/Medical Building

    175 Running Hill Rd, South Portland, ME 04106

    Class A office/medical building with suites available for lease.

    • Class A office/medical building with suites available, ranging from 4,646 to 8,542± SF.
    • Central location with easy access to Maine Turnpike/I‑95 and I‑295.
    • Conveniently located near Portland International Jetport, hotels, and restaurants.
    • Professionally managed property situated on 13.09± acres.
    • Ample paved parking available.
    Updated: Jul 29, 2025
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    South Portland Medical Office Building
    $26 SF/Yr
    17,071 SF

    South Portland Medical Office Building

    Prime Medical Office Space Available

    244 Western Ave, South Portland, ME 04106
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    Updated Medical Spa Space Available
    Contact for pricing
    4,200 SF

    Updated Medical Spa Space Available

    Recently updated medical spa, salon, or medical space for lease.

    198 Maine Mall Rd, South Portland, ME 04106
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    Based on your search, we've compiled 11 Potential Opportunities for your consideration. Besides 4 Active listings in South Portland, ME, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

    Explore Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Portland Office Space for Lease
    $8 SF/Yr
    4,580 SF

    Portland Office Space for Lease

    Flexible Offices, Coworking & More

    41 1St St, Portland, ME 04102
    View details
    Scarborough Office or Medical Space
    $16 SF/Yr
    3,000 SF

    Scarborough Office or Medical Space

    High-quality office/medical space with ample parking near major routes.

    23 Spring St, Scarborough, ME 04074
    View details
    Science Park Road Medical Office
    $12 SF/Yr
    34,457 SF

    Science Park Road Medical Office

    Scarborough, ME medical suites available

    1 Science Park Rd, Scarborough, ME 04074
    View details
    Thompson's Point Medical Office Space
    $25 SF/Yr
    60,410 SF

    Thompson's Point Medical Office Space

    Portland, ME Medical Office Building: 60,410 SF Available

    0 Thompsons Point Rd, Portland, ME 04102
    View details

    Explore Similar Spaces for Sale in South Portland, ME

    Consider Similar Space for Sale. We found 3 Spaces in Nearby Locations matching your search parameters.

    South Portland Office Suites for Lease
    $925,000
    4,530 SF

    South Portland Office Suites for Lease

    Office suites for lease near Maine Mall and major highways.

    25 Long Creek Dr, South Portland, ME 04106
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    South Portland Medical Investment Opportunity
    Contact for pricing
    7,424 SF

    South Portland Medical Investment Opportunity

    Long-term NNN investment with a strong healthcare tenant.

    254 Western Ave, South Portland, ME 04106
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    South Portland Medical Office Building
    Contact for pricing
    17,071 SF

    South Portland Medical Office Building

    17,071 SF Medical Office, Ample Parking

    244 Western Ave, South Portland, ME 04106
    View details

    South Portland, ME Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in South Portland, ME with 7 listings featured on our commercial real estate exchange. The current inventory includes 804,596,760 square feet of properties with an estimated lease value of $41 SF/Yr.

    Estimated lease rates for Medical Office Space in South Portland, ME begin at $15 SF/Yr, with an average of $20 SF/Yr and extend to $26 SF/Yr.
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