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    Des Moines, IA Commercial Real Estate for Lease

    172 results
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    Hub Tower
    Contact for pricing

    Hub Tower

    Workspaces, services and support to help you work better in Miami Airport

    699 Walnut St, Des Moines, IA 50309
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    IA, Des Moines - Grand Ave
    Contact for pricing

    IA, Des Moines - Grand Ave

    2323 Grand Ave, Des Moines, IA 50312

    Workspaces, services and support to help you work better in John Hancock Center

    • Be part of a vibrant coworking community with dedicated desk or hot desking options in thousands of idyllic locations across the globe
    • Grow in a modern workplace with the added advantage of a benefits program offering exclusive discounts and bespoke procurement support
    • Access Regus' network of workspaces and business lounges as often as you need and take advantage of their exclusive benefits
    • Impress clients, hold memorable workshops, and deliver a winning pitch in Regus' meeting spaces, fully equipped for gatherings of any size
    • Collaborate with like‑minded professionals and enjoy regular networking and community events with a Regus membership
    Updated: Feb 19
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    Office Space Near Sculpture Park
    $12 SF/Yr
    6,401 SF

    Office Space Near Sculpture Park

    1300 Walnut St, Des Moines, IA 50309

    Office space with exposed brick near restaurants and sculpture park.

    • Prime location within walking distance to numerous restaurants and attractions.
    • Close proximity to Pappajohn Sculpture Park.
    • Open ceilings with exposed brick and large windows.
    • Nearby parking garage available for tenant parking.
    • Tenant improvements available.
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    East Euclid Avenue Flex Space
    $12 SF/Yr
    8,500 SF

    East Euclid Avenue Flex Space

    Former tire service center suitable for auto, retail, or flex.

    1566 East Euclid Ave, Des Moines, IA 50313
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    Class A Office Retail Building
    $8 SF/Yr
    158,557 SF

    Class A Office Retail Building

    Eight-story Class A office and retail building in downtown Des Moines.

    400 Locust St, Des Moines, IA 50309
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    Retail Space with Ample Parking
    $13 SF/Yr
    1,587 SF

    Retail Space with Ample Parking

    Retail space with high visibility and ample parking.

    550 SW 9Th St, Des Moines, IA 50319
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    Office Space Near Krause Center
    $12 SF/Yr
    2,700 SF

    Office Space Near Krause Center

    Office space for lease near restaurants, fitness, and I-235.

    1533-1535 Linden St, Des Moines, IA 50309
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    Ingersoll Avenue Retail Opportunity
    Contact for pricing
    11,257 SF

    Ingersoll Avenue Retail Opportunity

    Retail space available in redeveloped Des Moines shopping center.

    2700 Ingersoll Ave, Des Moines, IA 50312
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    Des Moines Flex Space Available
    $6 SF/Yr
    7,204 SF

    Des Moines Flex Space Available

    Multi-tenant flex building near Des Moines CBD with ample parking.

    600 Southwest 7Th St, Des Moines, IA 50309
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    Des Moines Flex Space Available
    $5 SF/Yr
    8,344 SF

    Des Moines Flex Space Available

    Multi-tenant flex building with stable power and convenient location.

    601 Southwest 9Th St, Des Moines, IA 50309
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    Professional Office Suite For Rent
    $23 SF/Yr
    238 SF

    Professional Office Suite For Rent

    Eastside office suite with shared kitchenette and ample parking.

    1436 E 22Nd St, Des Moines, IA 50311
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    Des Moines Office Space Available
    $12 SF/Yr
    3,099 SF

    Des Moines Office Space Available

    Office space featuring private offices, conference room, and kitchenette.

    601 Forest Ave, Des Moines, IA 50314
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    Retail/Office Space Available 2026
    $23 SF/Yr
    1,991 SF

    Retail/Office Space Available 2026

    Retail/office space available summer 2026 in walkable neighborhood.

    3121 Ingersoll Ave, Des Moines, IA 50312
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    Fleur Drive Retail/Medical Space
    $15 SF/Yr
    2,275 SF

    Fleur Drive Retail/Medical Space

    Well-maintained retail or medical space in a high-traffic area.

    4214 Fleur Dr, Des Moines, IA 50321
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    Des Moines Office Space Available
    $12 SF/Yr
    9,593 SF

    Des Moines Office Space Available

    First floor office suite with conference room and restrooms.

    108 3Rd St, Des Moines, IA 50309
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    Retail Space with Individual Suites
    $19 SF/Yr
    2,844 SF

    Retail Space with Individual Suites

    Retail space featuring a reception area and individual suites.

    4926-4932 SE 14Th St, Des Moines, IA 50313
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    Restaurant/Retail Space For Lease
    $16 SF/Yr
    1,800 SF

    Restaurant/Retail Space For Lease

    Equipped restaurant/retail space with high visibility, convenient location.

    1103 Army Post Rd, Des Moines, IA 50315
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    Restored Historic Building Office Space
    $650 / Mo
    5,198 SF

    Restored Historic Building Office Space

    Flexible office space in a beautifully restored historic building.

    1163 24Th St, Des Moines, IA 50311
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    Freestanding Retail Space on Corner
    $24 SF/Yr
    4,092 SF

    Freestanding Retail Space on Corner

    Retail property with high visibility and existing restaurant infrastructure.

    4212 Merle Hay Rd, Des Moines, IA 50310
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    Retail Space Available For Rent
    $13 SF/Yr
    1,587 SF

    Retail Space Available For Rent

    Retail space available for lease in Des Moines, Iowa.

    520 Southwest 9Th St, Des Moines, IA 50309
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    Ingersoll Avenue Retail Space
    $34 SF/Yr
    9,560 SF

    Ingersoll Avenue Retail Space

    Versatile ground level retail space in a modern, sustainable building.

    3404-3422 Ingersoll Ave, Des Moines, IA 50312
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    Des Moines Flex/Office Space
    $1,450,000
    12,747 SF

    Des Moines Flex/Office Space

    Available flex and office space in Des Moines.

    101 Sheridan Ave, Des Moines, IA 50313
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    Des Moines Flex Space Available
    $8 SF/Yr
    3,356 SF

    Des Moines Flex Space Available

    3,356 SF flex space with mezzanine office in Des Moines.

    2100 Dixon St, Des Moines, IA 50316
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    Grand Avenue Office Building
    $20 SF/Yr
    90,223 SF

    Grand Avenue Office Building

    Five-story office building in DMU32 Health and Business Complex.

    3440 Grand Ave, Des Moines, IA 50312
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    Des Moines, IA Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Des Moines, IA with 365 listings featured on our commercial real estate exchange. The current inventory includes 161,274,758,040 square feet of properties with an estimated lease value of $1,068 /Mo.

    Estimated lease rates for Commercial real estate in Des Moines, IA begin at $1.50 SF/Yr, with an average of $14 SF/Yr and extend to $34 SF/Yr.
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