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    Lancaster, SC Commercial Real Estate for Sale

    51 results
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    Two Professional Buildings Near MUSC
    $975,000
    0.82 Acres

    Two Professional Buildings Near MUSC

    1201 Colonial Commons Court, Lancaster, SC 29720

    Two professional office buildings near MUSC in Lancaster, South Carolina.

    • Prime location minutes from MUSC (Medical University of South Carolina).
    • Two professional office buildings on one property.
    • Zoned "PO" Professional Office by the City of Lancaster.
    • Building 1 features a medical office layout with 14 rooms and a wired X‑ray room.
    • New flooring and new roof installed in Building 1.
    Updated: Dec 1, 2025
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    Versatile Land on Charlotte Highway
    $1,500,000
    5.61 Acres

    Versatile Land on Charlotte Highway

    Charlotte Highway, Lancaster, SC 29707

    5.61-acre wooded property with residential and commercial potential.

    • 5.61‑acre wooded property with residential and unimproved commercial potential.
    • Prime location on the corner of 521 and Henry Harris, with road frontage on a 4‑lane state highway, offering excellent visibility and convenient access.
    • Future land use map indicates potential for Commercial Zoning (as of 9/26/25) with Design and Environmental guidelines.
    • County Water available on 521 (tap fee required).
    • Subdivision possible (up to 3 lots due to moratorium).
    Updated: Nov 8, 2025
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    Prime Land on Highway 521
    $2,500,000
    3.96 Acres

    Prime Land on Highway 521

    3.96 acres ideal for commercial or residential development.

    6993 Charlotte Highway, Lancaster, SC 29707
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    19.32 Acres in Indian Land
    $625,000
    19.32 Acres

    19.32 Acres in Indian Land

    Land with natural features ideal for country living.

    6327 Witherspoon Trail, Lancaster, SC 29720
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    Commercial Lot on Highway S 200
    $69,900
    0.50 Acres

    Commercial Lot on Highway S 200

    Prime commercial lot with high visibility and utilities available.

    2067 Great Falls Highway, Lancaster, SC 29720
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    Commercial Lot on Highway S 200
    $69,000
    0.50 Acres

    Commercial Lot on Highway S 200

    Prime commercial lot with high visibility and utilities connected.

    2067 Great Falls Highway, Lancaster, SC 29720
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    Lancaster Land with Highway Frontage
    $1,600,000
    25.00 Acres

    Lancaster Land with Highway Frontage

    25 acres of land ideal for development or investment.

    3080 Charlotte Highway, Lancaster, SC 29720
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    Land For Sale, Lancaster SC
    $75,000
    0.47 Acres

    Land For Sale, Lancaster SC

    Commercial land available in Lancaster, South Carolina.

    10129 Lakeshore Drive, Lancaster, SC 29720
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    Lancaster Mixed-Use Commercial Opportunity
    $200,000
    0.22 Acres

    Lancaster Mixed-Use Commercial Opportunity

    Versatile property ideal for investors, businesses, or live/work arrangements.

    406 S Catawba Street, Lancaster, SC 29720
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    Lancaster Commercial Land For Sale
    $2,500,000
    18.00 Acres

    Lancaster Commercial Land For Sale

    Commercial land with development potential in Lancaster, South Carolina.

    Charlotte Hwy lot: 2, Lancaster, SC 29720
    View details
    Lancaster County Acreage with Development Potential
    $2,775,000
    84.67 Acres

    Lancaster County Acreage with Development Potential

    84.67 acres in Lancaster County ideal for various uses.

    1049 Culp Ferguson Road, Lancaster, SC 29720
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    Prime Development Land on Charlotte Highway
    $2,200,000
    15.55 Acres

    Prime Development Land on Charlotte Highway

    Development opportunity on a high-traffic corridor near residential developments.

    2383 Charlotte Highway, Lancaster, SC 29720
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    Prime Commercial Land on Charlotte Highway
    $2,200,000
    15.55 Acres

    Prime Commercial Land on Charlotte Highway

    15.55 acres with high traffic and development potential.

    2383 Charlotte Highway, Lancaster, SC 29720
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    Protected Timberland Tract in Lancaster
    $1,332,500
    533.00 Acres

    Protected Timberland Tract in Lancaster

    533-acre recreational timberland tract near Lancaster, South Carolina.

    Duckwood Rd., Lancaster, SC 29720
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    Versatile Commercial Building in Lancaster
    $349,000

    Versatile Commercial Building in Lancaster

    Two-story commercial building with offices in downtown Lancaster, SC.

    302 N White St, Lancaster, SC 29720
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    Wooded Acreage in Lancaster, SC
    $233,000
    11.12 Acres

    Wooded Acreage in Lancaster, SC

    11.12 acres of wooded land suitable for residential or agricultural.

    Bath Lane, Lancaster, SC 29720
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    Mixed-Use Commercial Property For Sale
    $450,000

    Mixed-Use Commercial Property For Sale

    Four buildings with six potential rental opportunities on 1.6 acres.

    2415 Pineview Drive, Lancaster, SC 29720
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    Turnkey Event Venue on 10.5 Acres
    $2,500,000
    6,058 SF

    Turnkey Event Venue on 10.5 Acres

    Established event venue in Lancaster, South Carolina, ready for operation.

    6815 Shiloh Unity Rd, Lancaster, SC 29720
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    Lancaster Light Industrial Facility
    $299,000
    3,400 SF

    Lancaster Light Industrial Facility

    3,400 SF facility on 2 acres near Rock Hill.

    1537 Lynwood Drive, Lancaster, SC 29720
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    Mixed-Use Investment Opportunity
    $1,150,000
    20,606 SF

    Mixed-Use Investment Opportunity

    Multi-tenant property with retail, office, industrial, and storage units.

    979-987 University Dr, Lancaster, SC
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    Retail Buildings For Sale
    $550,000
    2,175 SF

    Retail Buildings For Sale

    Two commercial buildings for sale in a growing area.

    1317 Hwy 9 ByPass W, Lancaster, SC 29720
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    Secluded Land with Creek Border
    $650,000
    77.99 Acres

    Secluded Land with Creek Border

    77+ acre lot perfect for recreation and residential use.

    Daystar Road unit: 14, Lancaster, SC 29720
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    Lancaster Convenience Store Opportunity
    $350,000

    Lancaster Convenience Store Opportunity

    Turnkey convenience store for sale with building, land, and inventory.

    715 S Market Street, Lancaster, SC 29720
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    Thriving Child Development Center
    $3,200,000
    9,398 SF

    Thriving Child Development Center

    Child development center with two buildings and outdoor playground.

    1699 N Rocky River Road, Lancaster, SC 29720
    View details

    Lancaster, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 51 commercial real estate for sale in Lancaster, SC, showcased through 51 active listings on our real estate platform. These investment opportunities span a total of 37,368,813 square feet of properties for sale, with an estimated market value of $24,001,300.

    Sale prices for business properties in Lancaster, SC start at $69,000, averaging $1,200,065, and reaching up to $2,775,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Most Searched ZIP Codes in Lancaster, SC

    • 29720
    • 29707

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