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    Port Isabel, TX Commercial Real Estate for Sale

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    Highway 100 Commercial Business Opportunity
    $1,500,000
    2,384 SF

    Highway 100 Commercial Business Opportunity

    321 Hwy 100, Port Isabel, TX 78578

    Turnkey business on Highway 100 in Port Isabel for sale.

    • Two established businesses (liquor store and convenience store) included in the sale.
    • Prime commercial location on Highway 100 in Port Isabel.
    • Includes building, equipment, inventory, and business.
    • Drive‑through window for liquor store convenience.
    • Well‑established business with 40+ years of family operation.
    Updated: Jan 1
    View details
    Multifaceted Coastal Investment Opportunity
    $9,000,000
    25,257 SF

    Multifaceted Coastal Investment Opportunity

    418 Hwy 100, Port Isabel, TX 78578

    Hospitality, recreation, and lifestyle investment in desirable coastal Texas.

    • Multifaceted commercial property with hospitality, recreation, and lifestyle businesses.
    • Includes 24 hotel rooms, a fully occupied 12‑unit apartment complex, and a full‑service restaurant & bar with new equipment.
    • Features 28 boat slips with direct bay access and a gas pump station for boats.
    • Includes an additional 1.68‑acre commercial property used for RV and boat storage, generating excellent revenue.
    • Turnkey businesses with over $2 million in recent renovations.
    Updated: Nov 6, 2025
    View details
    South Padre Island Duplex Investment
    $1,500,000
    3,506 SF

    South Padre Island Duplex Investment

    Luxury 2-unit beachfront duplex, high rental income.

    112 Dolphin Ln, South Padre Island, TX 78597
    View details
    Based on your search, we've compiled 337 Potential Opportunities for your consideration. Besides 3 Active listings in Port Isabel, TX, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 326 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Residential Lot in Shores Subdivision
    $290,000

    Residential Lot in Shores Subdivision

    Interior lot with access to beach and bay.

    105 Marina Dr, South Padre Island, TX 78597
    View details
    Long Island Waterfront Estate
    $17,500,000
    104.14 Acres

    Long Island Waterfront Estate

    104 Acres, Prime Location, SpaceX Views

    0 Vacant Land On Long Is, Brownsville, TX 78578
    View details
    South Padre Island Hotel - Bayfront Gem
    $4,500,000

    South Padre Island Hotel - Bayfront Gem

    50-Room Hotel, Prime Location, High ROI

    901 Padre Blvd, South Padre Island, TX 78597
    View details
    Downtown Brownsville Historic Building
    $1,199,000

    Downtown Brownsville Historic Building

    Prime Location, Two-Story Commercial Space

    1141 Elizabeth St, Brownsville, TX 78521
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Waterfront Commercial Lots in Port Isabel
    $2,190,000

    Waterfront Commercial Lots in Port Isabel

    Waterfront property on Intracoastal Waterway, ideal for development.

    Shore Dr South, Port Isabel, TX 78578
    View details
    Waterfront Lots on Intracoastal Waterway
    $3,285,000

    Waterfront Lots on Intracoastal Waterway

    Waterfront property ideal for commercial or residential development in Port Isabel.

    Shore Dr South, Port Isabel, TX 78578
    View details
    Port Isabel Acreage Ready to Develop
    Pending
    $265,000

    Port Isabel Acreage Ready to Develop

    1.30 acre commercial land parcel in Laguna Heights, Texas.

    47708 State Hwy 100 Hwy, Port Isabel, TX 78578
    View details
    Waterfront Commercial Lots in Port Isabel
    $1,220,750

    Waterfront Commercial Lots in Port Isabel

    Prime waterfront property with Intracoastal Waterway access in Port Isabel.

    Tbd Shr South, Port Isabel, TX 78578
    View details

    Explore Off-Market Properties in Port Isabel, TX

    Consider similar Off-Market properties in Port Isabel, TX. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    49116 State Hwy 48

    49116 State Hwy 48

    INDUSTRIAL (GENERAL) • 625.00 Acres
    Value Estimation by Request
    49116 State Hwy 48, Port Isabel, TX 78578
    View details
    Gomez St

    Gomez St

    WAREHOUSE, STORAGE • 2,400 SF
    Value Estimation by Request
    Gomez St, Port Isabel, TX 78578
    View details
    Monroe St

    Monroe St

    WAREHOUSE, STORAGE • 1,420 SF
    Value Estimation
    $535,000
    Monroe St, Port Isabel, TX 78578
    View details
    1723 State Hwy 100

    1723 State Hwy 100

    COMMERCIAL (GENERAL) • 18,684 SF
    Value Estimation
    $775,000
    1723 State Hwy 100, Port Isabel, TX 78578-2943
    View details
    241 Woody Ln

    241 Woody Ln

    COMMERCIAL (GENERAL) • 0.41 Acres
    Value Estimation by Request
    241 Woody Ln, Port Isabel, TX 78578
    View details
    613 Garcia St

    613 Garcia St

    COMMERCIAL (GENERAL) • 1,786 SF
    Value Estimation
    $405,000
    613 Garcia St, Port Isabel, TX 78578-4203
    View details
    212 Is Ave

    212 Is Ave

    COMMERCIAL (GENERAL) • 3,192 SF
    Value Estimation
    $435,000
    212 Is Ave, Port Isabel, TX 78578-2509
    View details
    239 Woody Ln

    239 Woody Ln

    COMMERCIAL (GENERAL) • 0.37 Acres
    Value Estimation by Request
    239 Woody Ln, Port Isabel, TX 78578-2469
    View details
    241 Woody Ln

    241 Woody Ln

    COMMERCIAL (GENERAL) • 0.37 Acres
    Value Estimation by Request
    241 Woody Ln, Port Isabel, TX 78578
    View details
    202 2nd St

    202 2nd St

    COMMERCIAL (GENERAL) • 3,162 SF
    Value Estimation
    $595,000
    202 2nd St, Port Isabel, TX 78578-4100
    View details
    600 Shr Dr

    600 Shr Dr

    COMMERCIAL (GENERAL) • 3,082 SF
    Value Estimation
    $435,000
    600 Shr Dr, Port Isabel, TX 78578-2565
    View details
    110 Wilson St

    110 Wilson St

    COMMERCIAL (GENERAL) • 2,016 SF
    Value Estimation
    $360,000
    110 Wilson St, Port Isabel, TX 78578
    View details
    209 Queen Isabella

    209 Queen Isabella

    COMMERCIAL (GENERAL) • 1,100 SF
    Value Estimation
    $385,000
    209 Queen Isabella, Port Isabel, TX 78578
    View details
    602 Garcia St

    602 Garcia St

    COMMERCIAL (GENERAL) • 0.07 Acres
    Value Estimation by Request
    602 Garcia St, Port Isabel, TX 78578-4203
    View details
    324 Queen Isabella

    324 Queen Isabella

    COMMERCIAL (GENERAL) • 0.07 Acres
    Value Estimation by Request
    324 Queen Isabella, Port Isabel, TX 78578-2407
    View details
    48 Sh

    48 Sh

    COMMERCIAL (GENERAL) • 10.00 Acres
    Value Estimation by Request
    48 Sh, Port Isabel, TX 78578
    View details
    218 Ws Shr Dr

    218 Ws Shr Dr

    COMMERCIAL (GENERAL) • 0.14 Acres
    Value Estimation
    $260,000
    218 Ws Shr Dr, Port Isabel, TX 78578
    View details
    503 State Hwy 100pi

    503 State Hwy 100pi

    COMMERCIAL (GENERAL) • 2,484 SF
    Value Estimation
    $410,000
    503 State Hwy 100pi, Port Isabel, TX 78578-2423
    View details
    115 Queen Isabella

    115 Queen Isabella

    COMMERCIAL (GENERAL) • 1,160 SF
    Value Estimation by Request
    115 Queen Isabella, Port Isabel, TX 78578-2436
    View details
    416 State Hwy 100

    416 State Hwy 100

    COMMERCIAL (GENERAL) • 720 SF
    Value Estimation by Request
    416 State Hwy 100, Port Isabel, TX 78578-0077
    View details
    100 Brg St

    100 Brg St

    COMMERCIAL (GENERAL) • 10,352 SF
    Value Estimation
    $420,000
    100 Brg St, Port Isabel, TX 78578-2905
    View details

    Port Isabel, TX Commercial Real Estate Investment Opportunities Market Analysis

    Explore 283 commercial real estate investment opportunities in Port Isabel, TX on our commercial real estate marketplace. The current inventory includes 4,915,086 square feet of properties with an estimated value of $74,262,729.

    Estimated prices for commercial real estate in Port Isabel, TX begin at $31,000, with an average of $439,424 and extend to $20,000,000.

    In Port Isabel, TX, current investment values show:

    • Other commercial real estate positioned at $444,252
    • Land measuring $4,377,545
    • Other land assessed at $10,623,364
    • Residential land & home lots calculated at $305,000
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    Most Searched ZIP Codes in Port Isabel, TX

    • 78578
    • 78597
    • 78587
    • 78758

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