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    Greenwood County, SC Commercial Real Estate for Sale

    168 results
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    Historic Uptown Greenwood Commercial Property
    $749,000
    4,684 SF

    Historic Uptown Greenwood Commercial Property

    206 Main St, Greenwood, SC 29649

    Versatile commercial space in a vibrant historic district with unique features.

    • Prime Location: Situated in the heart of Uptown Greenwood with high visibility and foot traffic.
    • Versatile Space: Just under 5,000 sqft with a flexible layout suitable for retail, office, or mixed‑use purposes. Includes seven private office suites, a shared kitchenette, and a large basement.
    • Historic Charm: Features original hardwood floors, ghost murals (including a vintage Coca‑Cola mural), and architectural details reflecting its 1917 origins.
    • Ample Parking: Benefits from an expansive city‑owned front lot providing abundant parking.
    • Turnkey Opportunity: Includes all remaining furnishings upstairs, making it ready for a new business/owner.
    Updated: Sep 9, 2025
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    Updated Office with Storage Building
    $999,000
    5,750 SF

    Updated Office with Storage Building

    425 Emerald Rd, Greenwood, SC 29646

    Updated office attached to a 5,500 sqft storage building.

    • Over 5,500 sqft of storage space in an elevated metal building.
    • Located in the Emerald Rd industrial corridor.
    • Property is completely fenced.
    • Updated front office building (built in 1979, updated in 2025) with office, conference room, and bathroom.
    • Two loading docks and loading dock ramp included.
    Updated: Oct 16, 2025
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    Greenwood Commercial Property For Sale
    $455,000
    12,646 SF

    Greenwood Commercial Property For Sale

    Two warehouse buildings on 1.83 acres in Greenwood, SC.

    205 Ginn St, Greenwood, SC 29646
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    Historic Grier Building Opportunity
    $610,000
    4,118 SF

    Historic Grier Building Opportunity

    Prime downtown Greenwood real estate with optional turn-key restaurant business.

    327 Main St, Greenwood, SC 29646
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    Greenwood Commercial Building with Warehouse
    $395,000
    10,000 SF

    Greenwood Commercial Building with Warehouse

    Office, showroom, and warehouse on a large corner lot.

    1201 Cambridge Ave, Greenwood, SC 29649
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    Iconic Mixed-Use Property, Greenwood SC
    $479,000
    4,753 SF

    Iconic Mixed-Use Property, Greenwood SC

    Mixed-use property in vibrant Uptown Greenwood, ideal for live/work.

    204 Main St, Greenwood, SC 29649
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    Ninety Six Commercial Property
    $175,000
    1,298 SF

    Ninety Six Commercial Property

    2.39-acre commercial property with 1,300 sq. ft. building.

    118 Cambridge St N, Ninety Six, SC 29666
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    Greenwood Car Wash Investment Opportunity
    $165,000
    1,956 SF

    Greenwood Car Wash Investment Opportunity

    Self-service car wash with growth potential on 0.64 acres.

    1005 Reynolds Ave, Greenwood, SC 29649
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    Industrial Property on 18+ Acres
    $3,995,000
    285,354 SF

    Industrial Property on 18+ Acres

    285,354 sqft industrial property with 18+ acres for sale.

    4730 Ninety Six Hwy, Ninety Six, SC 29666
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    Greenwood Commercial Property with Chef Kitchen
    $399,900
    2,554 SF

    Greenwood Commercial Property with Chef Kitchen

    Versatile property with chef's kitchen, suitable for residential or commercial.

    116 Charles St, Greenwood, SC 29649
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    Versatile Flex Building on Bypass 72
    $599,900
    20,000 SF

    Versatile Flex Building on Bypass 72

    20,884 SF flex building on 1.74 acres in Greenwood, SC.

    1732 72 By-Pass, Greenwood, SC 20649
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    Greenwood Commercial Property For Sale
    $650,000
    4,465 SF

    Greenwood Commercial Property For Sale

    Commercial property in Greenwood, SC with high visibility and traffic.

    106 Old Abbeville Hwy, Greenwood, SC 29649
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    Restaurant Property in Ware Shoals
    $139,000
    1,358 SF

    Restaurant Property in Ware Shoals

    Income-producing restaurant property with redevelopment potential in revitalizing downtown.

    27 Main Street Ext, Ware Shoals, SC 29692
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    Uptown Greenwood Multi-Use Corner Building
    $750,000
    5,308 SF

    Uptown Greenwood Multi-Use Corner Building

    Three-level commercial building with retail, office, and storage space.

    202 Main St, Greenwood, SC 29646
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    Greenwood Commercial Building Investment
    $100,000
    1.30 Acres

    Greenwood Commercial Building Investment

    High-traffic location, flexible zoning, great potential.

    1632 Cokesbury Rd, Greenwood, SC 29649
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    Days Inn Greenwood: Investment Opportunity
    $1,900,000
    1.40 Acres

    Days Inn Greenwood: Investment Opportunity

    Profitable Greenwood Hotel - 55 Rooms

    233 Birchtree Dr, Greenwood, SC 29649
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    Ware Shoals Warehouse - $225K
    $225,000
    4,400 SF

    Ware Shoals Warehouse - $225K

    ±4,400 SF Warehouse, Multi-Building Opportunity

    119 Greenwood Ave, Ware Shoals, SC 29692
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    Popeyes NNN Lease Investment
    $2,138,100
    2,145 SF

    Popeyes NNN Lease Investment

    High-Visibility QSR in SC

    1211 Bypass 25, Greenwood, SC 29649
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    Greenwood Multifamily Investment Opportunity
    $395,000
    5,000 SF

    Greenwood Multifamily Investment Opportunity

    Historic building, prime location, redevelopment potential.

    314 Jackson Ave, Greenwood, SC 29646
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    Greenwood SC Flex Space Investment
    $1,860,000
    30,890 SF

    Greenwood SC Flex Space Investment

    $1.86M, 30,890 SF Flex Space, 65% Occupancy

    707 Bypass 25, Greenwood, SC 29646
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    Greenwood, SC Retail Investment
    $5,462,000
    11,891 SF

    Greenwood, SC Retail Investment

    Corporate-guaranteed medical storefront, high NOI.

    311 Hampton Ave, Greenwood, SC 29646
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    Flex Space in Ware Shoals
    $185,000
    4 SF

    Flex Space in Ware Shoals

    Flex space opportunity in Ware Shoals, South Carolina for sale.

    119 South Greenwood Ave, Ware Shoals, SC 29692
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    Industrial Facility in Thriving Corridor
    Contact for pricing
    243,350 SF

    Industrial Facility in Thriving Corridor

    243,350 SF industrial facility in Greenwood, South Carolina.

    161 Rock Church Rd SE, Greenwood, SC 29649
    View details
    Retail Property in Ware Shoals
    $119,500
    1,988 SF

    Retail Property in Ware Shoals

    Retail property for sale in Ware Shoals, South Carolina.

    2 N Greenwood Ave, Ware Shoals, SC 29692
    View details

    Greenwood County, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 2495 commercial real estate investment opportunities in Greenwood County, SC with 168 listings featured on our commercial real estate marketplace. The current inventory includes 311,004,228 square feet of properties with an estimated value of $458,066,028.

    Estimated prices for commercial real estate in Greenwood County, SC begin at $30,000, with an average of $789,769 and extend to $13,415,000.

    In Greenwood County, SC, current investment values show:

    • Retail properties positioned at $882,452
    • Other commercial real estate measuring $812,843
    • Individual retail properties assessed at $841,952
    • Land calculated at $595,084
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