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    Poplar Bluff, MO Commercial Real Estate for Sale

    101 results
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    Turnkey Commercial Space with Warehouses
    $599,000
    4,337 SF

    Turnkey Commercial Space with Warehouses

    1401 Black Riv Industrial Park Rd, Poplar Bluff, MO 63901

    Two commercial buildings totaling 7437 SF on 3 acres.

    • Turnkey commercial space with two buildings totaling over 7400 square feet on 3 acres.
    • First building boasts 4300 sq ft with 6 roll‑up doors, concrete floors, heaters, winch spots, and a 500 sq ft office/retail space with central heat and air.
    • Second building offers 3100 sq ft with 8 large rolling doors, loading docks, high ceilings, and a renovated 400 sq ft office with heat and cooling.
    • Large open gravel lot for truck turnaround and additional 50 Amp connects.
    • Separate security and privacy fencing.
    Updated: Mar 3
    View details
    Westwood Blvd Commercial Opportunity
    $599,500
    5,280 SF

    Westwood Blvd Commercial Opportunity

    2016 N Westwood Blvd, Poplar Bluff, MO 63901

    Prime commercial building on main thoroughfare with income potential.

    • Prime commercial location on Westwood Blvd with high visibility and traffic.
    • 5,280 sq ft +/- building with ample on‑site parking.
    • Existing lease with reputable medical tenant generating $3,322/month income.
    • Second unit (up to 2,640 sq ft +/-) available for lease or owner occupancy.
    • Attractive lease rate of $10/sq ft for the available unit.
    Updated: Dec 1, 2025
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    Renovated Mixed-Use Commercial Space
    $79,900
    975 SF

    Renovated Mixed-Use Commercial Space

    Renovated commercial space with high visibility, suitable for various businesses.

    1614 S Broadway St, Poplar Bluff, MO 63901
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    Commercial Building with Rental Income
    $399,000
    3,600 SF

    Commercial Building with Rental Income

    3600 sq ft commercial building with three fully rented units.

    1600 W Maud St, Poplar Bluff, MO 63901
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    Commercial Land in Poplar Bluff
    $399,000
    6.64 Acres

    Commercial Land in Poplar Bluff

    6.64 acres of commercial land ready for development.

    3387 Kanell Blvd, Poplar Bluff, MO 63901
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    Commercial Building on 3.82 Acres
    $750,000
    4,560 SF

    Commercial Building on 3.82 Acres

    Multi-use building with expansion potential near future Interstate 57.

    140 W Outer Rd, Poplar Bluff, MO 63901
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    Versatile Commercial Space in Poplar Bluff
    $299,900
    3,475 SF

    Versatile Commercial Space in Poplar Bluff

    High-traffic location with remodeled space suitable for various business ventures.

    1025 S Westwood Blvd, Poplar Bluff, MO 63901
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    Versatile Building in Poplar Bluff
    $325,000
    12,351 SF

    Versatile Building in Poplar Bluff

    12351 SF building suitable for various purposes in Poplar Bluff.

    338 Hazel St, Poplar Bluff, MO 63901
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    Commercial Property in Poplar Bluff
    $48,000
    768 SF

    Commercial Property in Poplar Bluff

    Centrally-located commercial property suitable for investors or owner occupants.

    1517 Grove St, Poplar Bluff, MO 63901
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    Commercial Property in Poplar Bluff
    $1,495,000
    0.72 Acres

    Commercial Property in Poplar Bluff

    Commercial property with high traffic visibility and multiple business opportunities.

    3999 Highway Pp, Poplar Bluff, MO 63901
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    Versatile Commercial Property in Poplar Bluff
    $495,000

    Versatile Commercial Property in Poplar Bluff

    Two buildings with income potential in a high-traffic location.

    1029 S Westwood Rd, Poplar Bluff, MO 63901
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    Mixed-Use Property in Rural Setting
    $220,000
    4,800 SF

    Mixed-Use Property in Rural Setting

    Live and work property bordering national forest near Poplar Bluff.

    5914 Highway W, Poplar Bluff, MO 63901
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    Historic Mixed-Use Building
    Pending
    $299,900
    0.29 Acres

    Historic Mixed-Use Building

    Charming downtown building with storefront and potential living quarters.

    400 Vine St, Poplar Bluff, MO 63901
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    Commercial Land in Poplar Bluff
    $950,000
    1.50 Acres

    Commercial Land in Poplar Bluff

    1.5 acre commercial land with two buildings in high-traffic area.

    1030 Highway 67 S, Poplar Bluff, MO 63901
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    Commercial Lot on Highway 53
    $249,500

    Commercial Lot on Highway 53

    One-acre commercial lot with highway frontage and utilities.

    800 Highway 53, Poplar Bluff, MO 63901
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    Poplar Bluff Farmland Opportunity
    $60,000
    8.40 Acres

    Poplar Bluff Farmland Opportunity

    8 +/- acres of open farmland in a rural setting.

    693 County Road 605, Poplar Bluff, MO 63901
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    Income-Producing Property in Poplar Bluff
    $300,000

    Income-Producing Property in Poplar Bluff

    Commercial property with storage units, office, and residential rental income.

    2710- Oakmoore Dr, Poplar Bluff, MO 63901
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    Poplar Bluff Commercial Building For Sale
    $950,000
    6,500 SF

    Poplar Bluff Commercial Building For Sale

    6,500 sq ft building on 1.74 acres in Poplar Bluff.

    1026 Highway 67 S, Poplar Bluff, MO 63901
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    Prime Commercial Building in Poplar Bluff
    $1,500,000

    Prime Commercial Building in Poplar Bluff

    Commercial building with highway visibility and multiple units for sale.

    2000 N Westwood Blvd, Poplar Bluff, MO 63901
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    Poplar Bluff 16-Acre Land Parcel
    $89,900
    16.18 Acres

    Poplar Bluff 16-Acre Land Parcel

    16-acre property with Keener Springs branch, ideal for recreation.

    N Of Co Rd 450, Poplar Bluff, MO 63901
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    Commercial Lot on Highway 53
    $199,500

    Commercial Lot on Highway 53

    Commercial land with frontage on Highway 53 and city street.

    53 & Cross Highway, Poplar Bluff, MO 63901
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    Commercial Land in Poplar Bluff
    $65,000
    0.67 Acres

    Commercial Land in Poplar Bluff

    Commercial land available in Poplar Bluff, Missouri.

    2335 Cheshire Blvd, Poplar Bluff, MO 63901
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    Poplar Bluff Land For Sale
    $399,000
    4.00 Acres

    Poplar Bluff Land For Sale

    4 acre commercial land tract with highway frontage and utilities.

    Hwy. 67 South, Poplar Bluff, MO 63901
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    Versatile Land in Poplar Bluff
    $139,000
    23.40 Acres

    Versatile Land in Poplar Bluff

    23+/- acre tract suitable for pasture, recreation, or hunting.

    South Of Co Rd 450, Poplar Bluff, MO 63901
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    Poplar Bluff, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 41 commercial real estate for sale in Poplar Bluff, MO, showcased through 101 active listings on our real estate platform. These investment opportunities span a total of 5,459,584 square feet of properties for sale, with an estimated market value of $8,112,000.

    Sale prices for business properties in Poplar Bluff, MO start at $48,000, averaging $386,285, and reaching up to $1,495,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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