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    Poplar Bluff, MO Commercial Real Estate for Sale

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    Saint Louis, MO Kansas City, MO Louis, MO
    43 results
    Westwood Blvd Commercial Opportunity
    $599,500
    5,280 SF

    Westwood Blvd Commercial Opportunity

    2016 N Westwood Boulevard, Poplar Bluff, MO 63901

    Prime commercial building on main thoroughfare with income potential.

    • Prime commercial location on Westwood Blvd with high visibility and traffic.
    • 5,280 sq ft +/- building with ample on‑site parking.
    • Existing lease with reputable medical tenant generating $3,322/month income.
    • Second unit (up to 2,640 sq ft +/-) available for lease or owner occupancy.
    • Attractive lease rate of $10/sq ft for the available unit.
    Updated: Mar 20
    View details
    Commercial Building on 3.82 Acres
    $750,000
    4,560 SF

    Commercial Building on 3.82 Acres

    140 W Outer Rd., Poplar Bluff, MO 63901

    Multi-use building with expansion potential near future Interstate 57.

    • High‑visibility location near future Interstate 57 and M Hwy.
    • Multi‑use commercial building with 4560 sq ft under roof.
    • Includes existing spaces for both retail (salon) and office/sales.
    • Features a 1520 sq ft shop/garage area with 14 ft sidewalls.
    • Sits on 3.82 acres with room for expansion or additional buildings.
    Updated: Oct 27, 2025
    View details
    Turnkey Commercial Space with Warehouses
    $599,000
    4,337 SF

    Turnkey Commercial Space with Warehouses

    Two commercial buildings totaling 7437 SF on 3 acres.

    1401 Black River Industrial Park Road, Poplar Bluff, MO 63901
    View details
    Renovated Commercial Space, High Visibility
    $74,900
    975 SF

    Renovated Commercial Space, High Visibility

    Renovated commercial space with excellent visibility, ideal for various businesses.

    1614 S Broadway Street, Poplar Bluff, MO 63901
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    Versatile Commercial Space in Poplar Bluff
    $299,900
    3,475 SF

    Versatile Commercial Space in Poplar Bluff

    High-traffic location with remodeled space suitable for various business ventures.

    1025 S Westwood Boulevard, Poplar Bluff, MO 63901
    View details
    Commercial Building with Rental Income
    $399,000
    3,600 SF

    Commercial Building with Rental Income

    3600 sq ft commercial building with three fully rented units.

    1600 W Maud, Poplar Bluff, MO 63901
    View details
    Prime Commercial Building For Sale
    $1,500,000

    Prime Commercial Building For Sale

    Commercial building with four occupied units and highway visibility.

    2000 N Westwood Boulevard, Poplar Bluff, MO 63901
    View details
    Versatile Building in Poplar Bluff
    $325,000
    12,351 SF

    Versatile Building in Poplar Bluff

    12351 SF building suitable for various purposes in Poplar Bluff.

    338 Hazel St, Poplar Bluff, MO 63901
    View details
    Versatile Commercial Property in Poplar Bluff
    $495,000

    Versatile Commercial Property in Poplar Bluff

    Two buildings with income potential in a high-traffic location.

    1029 S Westwood, Poplar Bluff, MO 63901
    View details
    Commercial Land in Poplar Bluff
    $399,000
    6.64 Acres

    Commercial Land in Poplar Bluff

    6.64 acres of commercial land ready for development.

    3387 Kanell Boulevard, Poplar Bluff, MO 63901
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    Income-Producing Commercial Property For Sale
    $285,500

    Income-Producing Commercial Property For Sale

    Commercial property with storage units, office, and residential rental income.

    2710- 2712 Oakmoore Drive, Poplar Bluff, MO 63901
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    Live/Work Property Near National Forest
    $220,000
    4,800 SF

    Live/Work Property Near National Forest

    Mixed-use property with shop and living area on 3.78 acres.

    5914 Highway W, Poplar Bluff, MO 63901
    View details
    Commercial Property in Poplar Bluff
    $1,495,000
    0.72 Acres

    Commercial Property in Poplar Bluff

    Commercial property with high traffic visibility and multiple business opportunities.

    3999 Highway PP, Poplar Bluff, MO 63901
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    Poplar Bluff Retail Outparcel Land
    $75,000
    1.57 Acres

    Poplar Bluff Retail Outparcel Land

    1.57+/- acre commercial land in retail corridor.

    601 N Westwood, Poplar Bluff, MO 63901
    View details
    Commercial Property in Poplar Bluff
    $48,000
    768 SF

    Commercial Property in Poplar Bluff

    Centrally-located commercial property suitable for investors or owner occupants.

    1517 Grove Street, Poplar Bluff, MO 63901
    View details
    Poplar Bluff Commercial Land
    $450,000
    17.74 Acres

    Poplar Bluff Commercial Land

    17.74 acres of commercial land for sale.

    2579 Roxie Road Lots E, B & C, Poplar Bluff, MO 63901
    View details
    Former Police Station For Sale
    $499,000
    8,000 SF

    Former Police Station For Sale

    8000 sq ft commercial property in Poplar Bluff, Missouri.

    1111 Poplar Street, Poplar Bluff, MO 63901
    View details
    Poplar Bluff Farmland Opportunity
    $60,000
    1,056 SF

    Poplar Bluff Farmland Opportunity

    8 +/- acres of open farmland in a rural setting.

    693 County Road 605, Poplar Bluff, MO 63901
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    Commercial Lot in Poplar Bluff
    $89,500

    Commercial Lot in Poplar Bluff

    Level commercial lot with utilities in a retail center.

    0 Eugene Blvd., Poplar Bluff, MO 63901
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    Prime Retail/Office Center Opportunity
    Contact for pricing
    6,500 SF

    Prime Retail/Office Center Opportunity

    New retail/office center in growing Poplar Bluff location.

    2000 Shelby Road, Poplar Bluff, MO 63901
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    Poplar Bluff Vacant Land
    $79,900
    30.48 Acres

    Poplar Bluff Vacant Land

    27 acres M/L pond/slough and wooded property.

    0 S Highway 60 E, Poplar Bluff, MO 63901
    View details
    Poplar Bluff Land For Sale
    $399,000
    4.00 Acres

    Poplar Bluff Land For Sale

    4 acre commercial land tract with highway frontage and utilities.

    0 Hwy. 67 South, Poplar Bluff, MO 63901
    View details
    Commercial Land in Poplar Bluff
    $65,000
    0.67 Acres

    Commercial Land in Poplar Bluff

    Commercial land available in Poplar Bluff, Missouri.

    2335 Cheshire BLVD, Poplar Bluff, MO 63901
    View details
    Poplar Bluff 16-Acre Land Parcel
    $89,900
    16.18 Acres

    Poplar Bluff 16-Acre Land Parcel

    16-acre property with Keener Springs branch, ideal for recreation.

    0 N OF CO RD 450, Poplar Bluff, MO 63901
    View details

    Poplar Bluff, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 43 commercial real estate for sale in Poplar Bluff, MO, showcased through 43 active listings on our real estate platform. These investment opportunities span a total of 8,442,490 square feet of properties for sale, with an estimated market value of $7,292,100.

    Sale prices for business properties in Poplar Bluff, MO start at $48,000, averaging $383,794, and reaching up to $1,495,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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