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    Madison County, MO Commercial Real Estate for Sale

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    Open-Plan Office Units
    Updated: Jun 9
    Open-Plan Office Units

    152 S Main, Fredericktown, MO 63645

    $159,000
    1,538 sqft 0.09 AC lot
    1,538‑square‑foot office property on a 0.09‑acre site
    Reception area plus large open workspace
    Central air conditioning and forced‑air heating
    Accessible approach with ramp
    Public water and public sewer
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    Flexible Multi-Suite Office Building
    Updated: Oct 1
    Flexible Multi-Suite Office Building

    120 E College, Fredericktown, MO 63645

    $185,000
    0.19 AC lot
    Layout accommodates up to three businesses, each with an office, restroom, and separate entrance
    Interior can be opened into a single larger office configuration
    Roof updated approximately one year ago; some flooring recently replaced
    0.19‑acre corner lot close to downtown Fredericktown
    Off‑street parking, public water, and cable available
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    Drive-Through Restaurant
    Drive-Through Restaurant

    104 W College Avenue, Fredericktown, MO 63645

    $249,900
    0.26 AC lot

    The property includes a drive-through setup and walk-in cooler.

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    Working Farm with Multi-Generational Residence
    Working Farm with Multi-Generational Residence

    1575 Madison 220, Fredericktown, MO 63645

    $1,499,999
    11,508 sqft

    Livestock-ready agricultural property with multiple water sources, fenced pastures, extensive improvements, and a substantial residential compound.

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    Historic Restaurant with Patio
    Historic Restaurant with Patio

    406 Villar, Fredericktown, MO 63645

    $499,999
    1.48 AC lot

    Restored train depot with full-service dining, bar seating, patio, and included restaurant equipment.

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    Commercial Land with River Frontage
    Commercial Land with River Frontage

    Tract 5 off Hwy 72 Bypass, Fredericktown, MO 63645

    $995,000
    54.72 AC lot

    Commercially zoned land with public water and existing sewer and electric service on the property.

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    Three-Sided Frontage Commercial Land
    Three-Sided Frontage Commercial Land

    Tract 2 off Emerald Bluff Dr, Fredericktown, MO 63645

    $195,000
    1.84 AC lot

    Commercial land with frontage on three sides and on-site electric and water.

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    Freestanding Office Redevelopment Building
    Freestanding Office Redevelopment Building

    208 Lincoln Dr, Fredericktown, MO 63645

    $550,000
    23,166 sqft 1.62 AC lot

    Vacant, 23,166 SF freestanding all-brick office building on 1.62 acres, built in 1981 and ready for redevelopment.

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    Commercial Land Near Highway
    Commercial Land Near Highway

    Tract 4 off Hwy 72 Bypass, Fredericktown, MO 63645

    $150,000
    1.04 AC lot

    Commercial parcel with electric and water on site, plus sewer service available for future development.

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    Commercial Land with Dual Frontage
    Commercial Land with Dual Frontage

    Tract 3 off Emerald Bluff Drive, Fredericktown, MO 63645

    $150,000
    1.00 AC lot

    Commercial tract with electric and sewer on site, plus access from nearby Hwy 72 and its bypass.

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    Downtown Office Building
    Downtown Office Building

    152 South Main, Fredericktown, MO 63645

    $159,000
    1,538 sqft

    Former Vision Center offering a reception area and a large open space adaptable for offices.

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    Agricultural Land with Mature Pines
    Agricultural Land with Mature Pines

    Glenallen, MO 63645

    $135,000
    26.00 AC lot

    Agricultural zoning, electric availability, and a mix of open ground and mature pine woodland.

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    Creek-Bound Farmland with Pond
    Creek-Bound Farmland with Pond

    Tract 1 off Madison 9568, Fredericktown, MO 63645

    $289,000
    50.00 AC lot

    Rolling pasture offers fencing, available electric service, and several potential homesites in a wooded mountain setting.

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    Custom-Built Farmhouse With Hunting Acreage
    Custom-Built Farmhouse With Hunting Acreage

    29300 State Highway Yy, Marquand, MO 63655

    $549,000
    3,229 sqft

    Custom-built country home with a basement, geothermal heating and cooling, and a three-car garage.

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    Ozark Land with Spring-Fed Creek
    Ozark Land with Spring-Fed Creek

    129 Madison CR 410, Fredericktown, MO 63645

    $44,995
    3.00 AC lot

    2.5+/- acres with creek, camping spot near Mark Twain Forest.

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    Fenced Farm With Brick Residence
    Fenced Farm With Brick Residence

    Fredericktown, MO 63645

    $949,000
    3,980 sqft

    Pasture, hay production, water features, and farm improvements support active rural use.

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    Hilltop Short-Term Rental Cottage
    Hilltop Short-Term Rental Cottage

    1443 Madison 9563, Fredericktown, MO 63645

    $330,000
    416 sqft

    One-bedroom cottage with a covered porch, countryside outlooks, and an existing Airbnb operation.

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    Bar and Pub with Covered Patio
    Bar and Pub with Covered Patio

    1238 Highway OO, Fredericktown, MO 63645

    Contact for pricing
    4 sqft 4.00 AC lot

    An open interior and adaptable partition layout support a range of commercial configurations.

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    Wooded Recreation Land
    Wooded Recreation Land

    000 Rock Creek Road, Fredericktown, MO 63645

    $399,999
    43 sqft

    Versatile tract with paved-road access, productive ground, wooded cover, and potential for agricultural, residential, or hunting use.

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    Four-Bedroom Farm with Shop
    Four-Bedroom Farm with Shop

    1628 Madison 328, Marquand, MO 63655

    $184,999
    8 sqft

    Country property with a home, shop, pond, spring, and creek supporting agricultural and recreational use.

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    Freestanding Drive-Through Restaurant
    Freestanding Drive-Through Restaurant

    501 E Hwy 72, Fredericktown, MO 63645

    Contact for pricing
    3,531 sqft 1.77 AC lot

    Freestanding commercial building with an existing drive-through lane and access from E Highway 72.

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    Downtown Mixed-Use Storefronts
    Downtown Mixed-Use Storefronts

    140 East Main Street, Fredericktown, MO 63645

    $269,999

    Five historic buildings combine street-level commercial space with adaptable upper floors in downtown Fredericktown.

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    Wooded Hunting Land with Stream Access
    Wooded Hunting Land with Stream Access

    253 Madison St, Fredericktown, MO 63645

    $35,995
    6.69 AC lot

    A 6.687-acre wooded tract with deeded spring-fed stream access and a deeded gravel easement road.

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    Specialty Property for Sale
    Specialty Property for Sale

    202 Lincoln Dr, Fredericktown, MO 63645

    $195,000

    GPS-friendly property offered for sale in Madison County, Missouri.

    View details

    Madison County, MO Commercial Real Estate Market Trends and Statistics

    Explore 72 commercial real estate for sale in Madison County, MO, showcased through 25 active listings on our real estate platform. These investment opportunities span a total of 116,893 square feet of properties for sale, with an estimated market value of $8,175,885.

    Sale prices for business properties in Madison County, MO start at $35,995, averaging $371,631, and reaching up to $1,499,999 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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