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    High Springs, FL Commercial Real Estate for Sale

    10 results
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    Established Motel Business Opportunity
    $2,300,000
    3,902 SF

    Established Motel Business Opportunity

    19663 NW Us Highway 441, High Springs, FL 32643

    Established motel business with 19 rooms in prime location.

    • Established and running motel business with 19 rooms.
    • Prime location with high visibility and access from Hwy 441.
    • Includes owner's living quarters and private family area.
    • Potential for alternative business development.
    • Convenient access to I‑75 in both directions.
    Updated: Oct 8, 2025
    View details
    Historic Mixed-Use Building For Sale
    $270,000
    3,114 SF

    Historic Mixed-Use Building For Sale

    18616 NW 241 Ter, High Springs, FL 32643

    Two-story, 3,114 sq ft commercial building near downtown High Springs.

    • Prime Location: High‑traffic area near downtown High Springs, with excellent visibility and easy access to the interstate, restaurants, shopping, and the Santa Fe River.
    • Versatile C2 Zoning: Allows for a wide range of commercial and residential uses, offering flexibility.
    • Historic Charm with Modern Updates: Features original architectural details combined with updated metal roof, plumbing, electrical, bathrooms, and full kitchen for immediate use.
    • Spacious Interior: 3,114 sq ft across two floors with open‑plan spaces that can be customized.
    • Investment Opportunity: Potential to revitalize a historic space and capitalize on commercial opportunities.
    Updated: Nov 10, 2025
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    Restored Victorian Mixed-Use Property
    $425,000

    Restored Victorian Mixed-Use Property

    Restored Victorian property in downtown High Springs with commercial potential.

    18741 High Spring Main St, High Springs, FL 32643
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    1,159 SF on 0.35 AC Lot Office Building For Sale
    $272,000
    1,159 SF

    1,159 SF on 0.35 AC Lot Office Building For Sale

    1,159 SF on 0.35 AC Lot Office Building For Sale

    18245 NW Us Highway 441, High Springs, FL 32643
    View details
    Historic Commercial Building in High Springs
    $599,900

    Historic Commercial Building in High Springs

    7,620 SF commercial building in the heart of High Springs.

    18493 High Spring Main St, High Springs, FL 32643
    View details
    High Springs Industrial Flex Space
    $1,300,000
    11,992 SF

    High Springs Industrial Flex Space

    11,992 SF Flex Building, High Springs, FL

    25845 Us Highway 27, High Springs, FL 32643
    View details
    Historic Medical Office Building
    $364,000
    2,212 SF

    Historic Medical Office Building

    Iconic medical office building on HWY 441 in High Springs.

    18635 NW Us Highway 441, High Springs, FL 32643
    View details
    High Springs Manufactured Home Park
    $698,000

    High Springs Manufactured Home Park

    15-unit manufactured home park near Santa Fe River.

    22087 Us 441, High Springs, FL 32643
    View details
    High Springs Industrial Building For Sale
    $1,300,000
    11,992 SF

    High Springs Industrial Building For Sale

    11,992 SF industrial building fully leased to a national tenant.

    25845 W Us Highway 27, High Springs, FL 32643
    View details
    High Springs Duplex on Highway
    $190,000

    High Springs Duplex on Highway

    Duplex on US Highway 27, near downtown and springs.

    24522 W Us 27 Hwy, High Springs, FL 32643
    View details
    Based on your search, we've compiled 480 Potential Opportunities for your consideration. Besides 10 Active listings in High Springs, FL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 462 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    US-27 Industrial Land for Sale
    $200,000
    0.97 Acres

    US-27 Industrial Land for Sale

    High Springs, FL industrial land. Highway frontage.

    0 Us Highway 27, Fort White, FL 32643
    View details
    Land For Sale
    $499,000

    Land For Sale

    Land available for purchase.

    000 SW County Road 138, Fort White, FL 32038
    View details
    6.4 Acres Ready for Ranch
    $225,000
    6.40 Acres

    6.4 Acres Ready for Ranch

    High and dry land ideal for horses and farm animals.

    23206 NW 102Nd Ave, Alachua, FL 32615
    View details
    Land For Sale Alachua
    $135,000

    Land For Sale Alachua

    Land available for sale in Alachua, Florida.

    16404 NW 174Th Dr, Alachua, FL 32615
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Land For Sale
    $599,900

    Land For Sale

    Commercial land available for sale.

    18493 High Spg Main St, High Springs, FL 32643
    View details
    Land For Sale
    $425,000

    Land For Sale

    Commercial land available for sale.

    18741 High Spg Main St, High Springs, FL 32643
    View details
    High Springs Land For Sale
    $2,500,000
    36.79 Acres

    High Springs Land For Sale

    36+/- acre mixed-use property in High Springs, Florida.

    NW Us Hwy 441 Hwy NW, High Springs, FL 32643
    View details
    Prime Commercial Corner Parcel
    Pending
    $499,000
    5.00 Acres

    Prime Commercial Corner Parcel

    5-acre commercial land with high visibility and accessibility.

    20276 Us Highway 441, High Springs, FL 32643
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    Explore Off-Market Properties in High Springs, FL

    Consider similar Off-Market properties in High Springs, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    24067 187 Rd

    24067 187 Rd

    Multifamily properties • 2,509 SF
    Value Estimation by Request
    24067 187 Rd, High Springs, FL 32643
    View details
    26253 Hwy

    26253 Hwy

    Distribution properties • 6,500 SF
    Value Estimation by Request
    26253 Hwy, High Springs, FL 32643
    View details
    18646 High Spg Main St

    18646 High Spg Main St

    Restaurants • 5,956 SF
    Value Estimation by Request
    18646 High Spg Main St, High Springs, FL 32643
    View details
    25845 Hwy

    25845 Hwy

    Flex space • 11,992 SF
    Value Estimation by Request
    25845 Hwy, High Springs, FL 32643
    View details
    17404 Us Hwy 441

    17404 Us Hwy 441

    WAREHOUSE, STORAGE • 4,800 SF
    Value Estimation by Request
    17404 Us Hwy 441, High Springs, FL 32643-9378
    View details
    3862 County Rd 340

    3862 County Rd 340

    DISTRIBUTION WAREHOUSE • 10,900 SF
    Value Estimation
    $705,000
    3862 County Rd 340, High Springs, FL 32643-5603
    View details
    80 Ave

    80 Ave

    TRUCK TERMINAL (MOTOR FREIGHT) • 828 SF
    Value Estimation by Request
    80 Ave, High Springs, FL 32643
    View details
    3529 64th Ave

    3529 64th Ave

    WAREHOUSE, STORAGE • 1,056 SF
    Value Estimation
    $805,000
    3529 64th Ave, High Springs, FL 32643-5590
    View details
    Cr 340

    Cr 340

    TRUCK TERMINAL (MOTOR FREIGHT) • 143 SF
    Value Estimation by Request
    Cr 340, High Springs, FL 32643
    View details
    High Springs, FL 32643

    High Springs, FL 32643

    R&D FACILITY, LABS, PHARMA • 2.22 Acres
    Value Estimation by Request
    High Springs, FL 32643
    View details
    High Springs, FL 32643

    High Springs, FL 32643

    R&D FACILITY, LABS, PHARMA • 0.82 Acres
    Value Estimation by Request
    High Springs, FL 32643
    View details
    High Springs, FL 32643

    High Springs, FL 32643

    R&D FACILITY, LABS, PHARMA • 4.94 Acres
    Value Estimation by Request
    High Springs, FL 32643
    View details
    17421 239th Ter

    17421 239th Ter

    WASTE DISPOSAL, SEWAGE • 0.33 Acres
    Value Estimation by Request
    17421 239th Ter, High Springs, FL 32643-6317
    View details
    17992 244th St

    17992 244th St

    WAREHOUSE, STORAGE • 7,500 SF
    Value Estimation by Request
    17992 244th St, High Springs, FL 32643-4196
    View details

    High Springs, FL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 345 commercial real estate investment opportunities in High Springs, FL with 10 listings featured on our commercial real estate marketplace. The current inventory includes 80,188,917 square feet of properties with an estimated value of $94,364,680.

    Estimated prices for commercial real estate in High Springs, FL begin at $55,000, with an average of $412,072 and extend to $4,065,000.

    In High Springs, FL, current investment values show:

    • Retail properties positioned at $355,147
    • Industrial properties measuring $440,865
    • Individual retail properties assessed at $337,549
    • Other warehouses calculated at $401,923
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    Browse Commercial real estate for Sale Near High Springs, FL

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    Most Searched ZIP Codes in High Springs, FL

    • 32643

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