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    Chillicothe, OH Commercial Real Estate for Lease

    10 results
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    Renovated Office Space, Downtown Location
    $1,100 / Mo
    1,080 SF

    Renovated Office Space, Downtown Location

    Chillicothe, OH 45601

    Newly renovated office space in historic downtown Chillicothe.

    • Prime downtown location in the historic district.
    • Newly renovated, move‑in‑ready office space.
    • Functional layout featuring a lobby, reception area, two private offices, and conference room.
    • Private parking and front/back private entrances.
    • Kitchen includes new appliances.
    Updated: Mar 4
    View details
    Downtown Retail Space Available
    $15 SF/Yr
    2,750 SF

    Downtown Retail Space Available

    23 N Bridge St, Chillicothe, OH 45601

    Prime retail space in downtown Chillicothe with high visibility.

    • Prime Downtown Location on N Bridge Street
    • High Visibility & Foot Traffic
    • Boasting 123’ of Frontage
    • 2,900 SF Retail Space with Flexible Layout
    • Walkable Amenities: Restaurants, Shops, Historic Attractions
    Updated: Sep 11, 2025
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    Zane Plaza: Chillicothe Retail Space
    Contact for pricing
    147,000 SF

    Zane Plaza: Chillicothe Retail Space

    Prime Chillicothe retail space available. High traffic, excellent visibility.

    1080 Bridge St, Chillicothe, OH 45601
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    Chillicothe Office/Retail Space
    $13 SF/Yr
    2,200 SF

    Chillicothe Office/Retail Space

    2,200 SF Single-Tenant Office Building

    114 Renick Ave, Chillicothe, OH 45601
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    Industrial Space Along US 23
    Contact for pricing
    100,000 SF

    Industrial Space Along US 23

    Industrial property with build-to-suit options and tax abatement.

    1101 River Rd, Chillicothe, OH 45601
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    Chillicothe Retail Land Redevelopment
    Contact for pricing
    108,029 SF

    Chillicothe Retail Land Redevelopment

    Prime 2-acre retail outparcel, high traffic.

    1334 Bridge St, Chillicothe, OH 45601
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    North Bridge Street Retail Pad Site
    Contact for pricing
    31,363 SF

    North Bridge Street Retail Pad Site

    Chillicothe, OH retail opportunity. Prime location, high traffic.

    1251 Bridge St, Chillicothe, OH 45601
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    Guernsey Crossing Retail Center
    Contact for pricing
    105,000 SF

    Guernsey Crossing Retail Center

    Chillicothe, OH Power Center - 105,000 SF

    159 At Seney Rd, Chillicothe, OH 45601
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    Retail Power Center Space Available
    Contact for pricing

    Retail Power Center Space Available

    Prime retail space in regional shopping destination with excellent visibility.

    Seney Rd, Chillicothe, OH 45601
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    Retail Center Near I-35
    Contact for pricing
    1,500 SF

    Retail Center Near I-35

    154,000 SF retail center near I-35 and Bridge Street.

    2-144 Consumer Center Dr, Chillicothe, OH 45601
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    Based on your search, we've compiled 40 Potential Opportunities for your consideration. Besides 10 Active listings in Chillicothe, OH, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 26 Properties for Sales.

    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office and Warehouse Space Available
    $8 SF/Yr
    20,800 SF

    Office and Warehouse Space Available

    Two-story office and warehouse space for lease.

    1950 Stoneridge Dr, Circleville, OH 43113
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    Circleville Gateway Retail Spaces
    Contact for pricing
    81,940 SF

    Circleville Gateway Retail Spaces

    Prime Pickaway County retail spaces, drive-thru ready.

    1250 Court St, Circleville, OH 43113
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    Rickenbacker Area Warehouse Space
    Contact for pricing
    509,257 SF

    Rickenbacker Area Warehouse Space

    Warehouse space in Rickenbacker area, near major transportation routes.

    3780 Tradeport Ct, Ashville, OH
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    Industrial Space in Rickenbacker Park
    Contact for pricing
    1,027,649 SF

    Industrial Space in Rickenbacker Park

    Industrial space available for lease in Groveport, Ohio.

    4229 Raymond Ave, Ashville, OH
    View details

    Explore Similar Spaces for Sale in Chillicothe, OH

    Consider Similar Space for Sale. We found 26 Spaces in Nearby Locations matching your search parameters.

    Commercial Land on US-23
    $325,000
    7.86 Acres

    Commercial Land on US-23

    7.86 acre commercial parcel with high visibility on US-23.

    Us Highway 23, Chillicothe, OH 45601
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    Commercial Land in Bustling Corridor
    $525,000
    3.72 Acres

    Commercial Land in Bustling Corridor

    3.72-acre commercial parcel in Chillicothe's heart, primed for development.

    Pawnee Rd, Chillicothe, OH 45601
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    Main Street Investment Opportunity
    $550,000
    5,244 SF

    Main Street Investment Opportunity

    High-visibility commercial building with established tenants in a prime location.

    946-954 E Main St, Chillicothe, OH 45601
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    Cozy Inn Bar & Grill
    $399,999

    Cozy Inn Bar & Grill

    Iconic Chillicothe bar and grill with loyal customer base.

    339 Western Ave, Chillicothe, OH 45601
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    Chillicothe Equestrian Estate For Sale
    $595,000
    2,400 SF

    Chillicothe Equestrian Estate For Sale

    Mini equestrian estate featuring a family home and horse barn.

    141 Delano Rd, Chillicothe, OH 45601
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    High-Traffic Commercial Property in Chillicothe
    $169,900
    1,496 SF

    High-Traffic Commercial Property in Chillicothe

    Versatile commercial building on East Main Street with high visibility.

    945 E Main St, Chillicothe, OH 45601
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    Prime Retail Ground Lease Opportunity
    Contact for pricing
    1.35 Acres

    Prime Retail Ground Lease Opportunity

    1.35 acre commercial land in high-traffic retail corridor.

    1487 Bridge St, Chillicothe, OH 45601
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    Retail Space on Bridge Street
    Contact for pricing

    Retail Space on Bridge Street

    NNN lease opportunity in Chillicothe, with high visibility.

    27 Bridge St, Chillicothe, OH 45601
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    Downtown Chillicothe Mixed-Use Building
    $214,900
    2,200 SF

    Downtown Chillicothe Mixed-Use Building

    Versatile building in historic downtown Chillicothe with retail and residential/office potential.

    13 W 2Nd St, Chillicothe, OH 45602
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    Downtown Chillicothe Mixed-Use Building
    $125,000

    Downtown Chillicothe Mixed-Use Building

    Three-story commercial building with storefront and apartments in historic downtown.

    20 E Main St, Chillicothe, OH 45601
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    Downtown Chillicothe Mixed-Use Investment
    $214,900
    2,200 SF

    Downtown Chillicothe Mixed-Use Investment

    Versatile building in historic Union Block with retail and residential potential.

    11 W 2Nd St, Chillicothe, OH 45601
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    Buildable Land in Adena School
    $175,000
    10.00 Acres

    Buildable Land in Adena School

    10 flat acres ideal for building or recreation.

    14839 Westfall Rd, Chillicothe, OH 45601
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    Renovated Mixed-Use Building For Sale
    $650,000

    Renovated Mixed-Use Building For Sale

    Renovated mixed-use building with high visibility and ample parking.

    7 Saint Andrews Blvd, Chillicothe, OH 45601
    View details
    Commercial Land on US Route
    $325,000
    7.86 Acres

    Commercial Land on US Route

    7.86-acre commercial parcel with high visibility on US Route 23.

    Us Rt 23, Chillicothe, OH 45601
    View details

    Chillicothe, OH Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Chillicothe, OH with 36 listings featured on our commercial real estate exchange. The current inventory includes 4,618,666,800 square feet of properties with an estimated lease value of $45 SF/Yr.

    Estimated lease rates for Commercial real estate in Chillicothe, OH begin at $4 SF/Yr, with an average of $11 SF/Yr and extend to $15 SF/Yr.
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