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    Poplar Bluff, MO Commercial Real Estate for Lease

    13 results
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    Downtown Mixed-Use Commercial Space
    $500 / Mo
    1,200 SF

    Downtown Mixed-Use Commercial Space

    106 S Main St, Poplar Bluff, MO 63901

    1,200 sq ft mixed-use space in historic downtown Poplar Bluff.

    • Prime downtown location in historic Poplar Bluff with high traffic and visibility.
    • Flexible 1,200 sq ft mixed‑use space suitable for office, retail, studio, or professional services.
    • Street‑level storefront with excellent overhead signage potential for branding.
    • Readily available on‑street parking and a private parking lot for convenience.
    • Functional layout with 2‑3 private offices, common area, and restroom.
    Updated: Jan 10
    View details
    Westwood Village Retail Space
    $1,550 / Mo
    18,000 SF

    Westwood Village Retail Space

    2201 Westwood Blvd N, Poplar Bluff, MO 63901

    Retail space in established Westwood Village Shopping Center.

    • Located in Westwood Village Shopping Center on busy Westwood Blvd.
    • High street visibility and easy access.
    • Ample parking space.
    • 1200 sq.ft. unit is mostly open.
    • Includes one generously sized office and a private restroom.
    Updated: Nov 26, 2025
    View details
    Versatile Commercial Space on Highway
    $4,000 / Mo
    8,000 SF

    Versatile Commercial Space on Highway

    8,000 sq ft building for lease or sale.

    2323 Cheshire Blvd, Poplar Bluff, MO 63901
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    6,500 SF Commercial Space
    $6,000 / Mo
    31,363 SF

    6,500 SF Commercial Space

    6,500 SF commercial space for lease in Poplar Bluff, MO.

    3999 Highway Pp, Poplar Bluff, MO 63901
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    Small Office Space For Rent
    $500 / Mo

    Small Office Space For Rent

    Office space for rent, utilities included, common waiting area.

    2051 N Westwood Blvd, Poplar Bluff, MO 63901
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    Prime Retail/Office Space Available
    $1,850 / Mo
    1,862 SF

    Prime Retail/Office Space Available

    Highly visible 1,860 sq ft commercial suite for lease.

    1201 Sterling Dr, Poplar Bluff, MO 63901
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    Remodeled Retail/Office Space Available
    $1,100 / Mo

    Remodeled Retail/Office Space Available

    Remodeled 1,000 sq ft retail/office space in high-traffic location.

    1106 Vine St, Poplar Bluff, MO 63901
    View details
    Office Space with Utilities Included
    $700 / Mo

    Office Space with Utilities Included

    Office space featuring an open area and included utilities.

    2051 N Westwood Blvd, Poplar Bluff, MO 63901
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    Prime Retail/Office Space Available
    $1,850 / Mo
    1,960 SF

    Prime Retail/Office Space Available

    Highly visible 1,960 sq ft commercial suite for lease.

    1213 Sterling Dr, Poplar Bluff, MO 63901
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    Eight Points Retail Opportunity
    Contact for pricing
    1 SF

    Eight Points Retail Opportunity

    Poplar Bluff, MO retail pads available

    67 & Oak Grv Rd, Poplar Bluff, MO 63901
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    Retail Space in Poplar Bluff
    $12 SF/Yr
    3,630 SF

    Retail Space in Poplar Bluff

    Retail spaces available in a busy shopping center.

    715-797 N Westwood Blvd, Poplar Bluff, MO 63901
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    Prime Retail Space Available
    $16 SF/Yr
    3,200 SF

    Prime Retail Space Available

    Retail spaces in high-traffic Poplar Bluff location.

    1915-1935 N Westwood Blvd, Poplar Bluff, MO 63901
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    Retail Space in Poplar Bluff
    $15 SF/Yr
    1,200 SF

    Retail Space in Poplar Bluff

    Retail space available in a busy shopping center.

    1361-1429 N Westwood Blvd, Poplar Bluff, MO 63901
    View details
    Based on your search, we've compiled 43 Potential Opportunities for your consideration. Besides 13 Active listings in Poplar Bluff, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 25 Properties for Sales.

    Explore Commercial Real Estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Multi-Unit Shopping Center For Rent
    $800 / Mo
    50,530 SF

    Multi-Unit Shopping Center For Rent

    Multi-unit shopping center with warehouse and retail space available for rent.

    1106 N Douglas, Malden, MO 63940
    View details
    Main Street Retail Space - Malden, MO
    $7 SF/Yr
    15,000 SF

    Main Street Retail Space - Malden, MO

    15,000 SF Retail Space Available

    310 Main St, Malden, MO 63863
    View details
    Retail Property in St. Robert
    Contact for pricing
    38,094 SF

    Retail Property in St. Robert

    Retail property offering 38,094 sq. ft. for rent.

    332 Marshall Dr, St Robert, MO
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    Commercial Pads For Lease
    Contact for pricing

    Commercial Pads For Lease

    Multiple commercial pads available for lease in St. Robert.

    338-400 Marshall Dr, St Robert, MO
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Retail Development Land Available
    Contact for pricing

    Prime Retail Development Land Available

    Land for lease in a high-traffic retail development.

    67 & Oak Grv Rd, Poplar Bluff, MO
    View details

    Explore Similar Spaces for Sale in Poplar Bluff, MO

    Consider Similar Space for Sale. We found 25 Spaces in Nearby Locations matching your search parameters.

    Commercial Property in Poplar Bluff
    $1,495,000
    0.72 Acres

    Commercial Property in Poplar Bluff

    Commercial property with high traffic visibility and multiple business opportunities.

    3999 Highway Pp, Poplar Bluff, MO 63901
    View details
    Prime Commercial Building in Poplar Bluff
    $1,500,000

    Prime Commercial Building in Poplar Bluff

    Commercial building with highway visibility and multiple units for sale.

    2000 N Westwood Blvd, Poplar Bluff, MO 63901
    View details
    Turnkey Commercial Space in Poplar Bluff
    $625,000
    4,337 SF

    Turnkey Commercial Space in Poplar Bluff

    Two commercial buildings totaling 7437 SF on 3 acres.

    1401 Black Riv Industrial Park Rd, Poplar Bluff, MO 63901
    View details
    Poplar Bluff Commercial Building For Sale
    Pending
    $115,000
    3,000 SF

    Poplar Bluff Commercial Building For Sale

    Commercial building on Business Hwy 60, suitable for multiple uses.

    926 W Pine St, Poplar Bluff, MO 63901
    View details
    Commercial Building on 3.82 Acres
    $750,000
    4,560 SF

    Commercial Building on 3.82 Acres

    Multi-use building with expansion potential near future Interstate 57.

    140 W Outer Rd, Poplar Bluff, MO 63901
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    Versatile Commercial Space in Poplar Bluff
    $299,900
    3,475 SF

    Versatile Commercial Space in Poplar Bluff

    High-traffic location with remodeled space suitable for various business ventures.

    1025 S Westwood Blvd, Poplar Bluff, MO 63901
    View details
    Versatile Building in Poplar Bluff
    $350,000
    12,351 SF

    Versatile Building in Poplar Bluff

    12351 SF building suitable for various uses in Missouri.

    338 Hazel St, Poplar Bluff, MO 63901
    View details
    Versatile Commercial Building on Highway
    $419,000
    8,000 SF

    Versatile Commercial Building on Highway

    8,000 sq ft building on high-traffic Highway 53.

    2323 Cheshire Blvd, Poplar Bluff, MO 63901
    View details
    Commercial Building with Rental Income
    $399,000
    3,600 SF

    Commercial Building with Rental Income

    3600 sq ft commercial building with three fully rented units.

    1600 W Maud St, Poplar Bluff, MO 63901
    View details
    Remodeled Downtown Commercial Building Opportunity
    $139,500
    7,400 SF

    Remodeled Downtown Commercial Building Opportunity

    Recently remodeled 7,400 sqft commercial building in Poplar Bluff's Entertainment Zone.

    413 Vine St, Poplar Bluff, MO 63901
    View details
    Renovated Commercial Space, Poplar Bluff
    $84,900
    975 SF

    Renovated Commercial Space, Poplar Bluff

    Renovated mixed-use space with high visibility, move-in ready.

    1614 S Broadway St, Poplar Bluff, MO 63901
    View details

    Poplar Bluff, MO Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Poplar Bluff, MO with 38 listings featured on our commercial real estate exchange. The current inventory includes 3,067,286,078 square feet of properties with an estimated lease value of $80 SF/Yr.

    Estimated lease rates for Commercial Real Estate in Poplar Bluff, MO begin at $1.03 SF/Yr, with an average of $8 SF/Yr and extend to $16 SF/Yr.

    In Poplar Bluff, MO, current lease rates show:

    • Individual retail properties positioned at $9
    • Retail properties measuring $9
    • Retail space assessed at $9
    • Office Properties & Spaces calculated at $7
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    Popular Searches in Poplar Bluff, MO

    Most Searched ZIP Codes in Poplar Bluff, MO

    • 63901

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