Brentwood, MO Commercial real estate for Rent & Lease

Updated: Nov 22, 2025

Class A Office Space Available

1405 South Hanley Road, Brentwood, MO 63144

$28.50 SF/Yr

30,000 sqft

Premier Class A office space in a highly desirable St. Louis market.
Dedicated MetroLink stop on site for convenient access.
Ample free parking (5/1000) in a multi‑story garage with covered walkways.
Unmatched visibility and unbeatable access.
Executive conferencing and auditorium facilities available.

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Updated: Nov 22, 2025

Brentwood Office Space For Lease

8374 Eager Road, Brentwood, MO 63144

$25 SF/Yr

70,000 sqft

+70,000 SF available on 2nd floor
Dedicated MetroLink stop on site for easy commuting
Free 5/1000 Parking in multistory parking garage
Located in a premier mixed‑use development
Open, efficient floor plan

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Manchester Road Retail/Office/Medical Space

8500-8518 Manchester Rd, Brentwood, MO

Triple net (NNN)

Contact for pricing

2,600 sqft

Prime commercial space suitable for retail, office, or medical use.

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Retail Space on Brentwood Boulevard

2530-2554 S Brentwood Blvd, Brentwood, MO

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1,250 sqft

Retail space available with excellent visibility and pylon signage.

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Brentwood Office Space For Lease

8328-8374 Eager Rd, Brentwood, MO

Full service

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280–466 people 1 space 70,000 sqft 12.28 acres

70,000 SF office space with dedicated MetroLink stop.

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5 active listings match your search: For lease in Brentwood, MO. Based on your search, we've also compiled 5 Potential Opportunities for your consideration: 4 spaces in nearby cities and 1 property for sale.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Space with Private Entrance

2117-2121 S Brentwood Blvd, Saint Louis, MO 63144

$20 SF/Yr

13–22 people 1 space 3,418 sqft

Two-level office suite offers private entrance, multiple offices, and built-in kitchen and breakroom areas.

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Class A Office Space Available

Saint Louis, MO 63144

$28.50 SF/Yr

416–693 people 104,000 sqft

Premier St. Louis office space with unmatched amenities and access.

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Second-Floor Office Suite

7225 Manchester Road, Maplewood, MO 64143

$950/Mo

Floor 2

2 private offices Road access

Two private offices and a waiting area are available with utilities and maintenance included.

Separate entrance

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Retail Space in Maple Wood

Maplewood, MO

Contact for pricing

3,980 sqft

Retail spaces available in a power center, 1,400-19,710 SF.

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Similar Spaces for Sale in Brentwood, MO

Consider Similar Space for Sale. We found 1 Spaces matching your search parameters.

Brentwood Development Ready Land

8300 Manchester Rd, Brentwood, MO

Contact for pricing

1.06 AC lot

Strategic location with development potential in Brentwood area.

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Brentwood, MO Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in Brentwood, MO with 5 listings featured on our commercial real estate exchange. The current inventory includes 173,850 square feet of properties with an estimated lease value of $53.50.

Estimated lease rates for Commercial real estate in Brentwood, MO begin at $25 SF/Yr, with an average of $26.75 SF/Yr and extend to $28.50 SF/Yr.

Brentwood, MO CRE market trends — vacancy, lease rates and price per SF, updated monthly