Des Peres, MO Commercial real estate for Rent & Lease

Updated: Nov 22, 2025

Des Peres Office Space Available

13075 Manchester Road, Des Peres, MO 63131

$32.50 SF/Yr

5,630 sqft

5,630 square feet of office space

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Updated: Nov 23, 2025

Retail Space in Des Peres

12107-12129 Manchester Rd, Des Peres, MO

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3,164 sqft 7.77 AC lot

Anchored by T.J. Maxx, ALDI, McAlister’s Deli, and Salon Lofts
Located near I‑270 and West County Center with high visibility on Manchester Rd.
Located in affluent Des Peres, MO
Close proximity to West County Center (Nordstrom, Macy’s, JC Penney, Dick’s Sporting Goods, Barnes & Noble)
Full‑service traffic signal provides easy access

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Des Peres Retail Space Available

11781 Manchester Road, Des Peres, MO 63131

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3,694 sqft

3,694 SF office/retail space on Manchester Road.

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Office Space with Updated Lobby

13075 Manchester Rd, Des Peres, MO 63131

Full service

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19–32 people 1 space 4,817 sqft

Office space with an updated lobby and a sublease term through August 31, 2028.

Full Service Tenant Café Updated Lobby

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Leased Commercial Building with Homes

1091 Kinstern Dr, Des Peres, MO

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0.63 acres

Fully leased commercial building plus two residential homes for rent.

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Retail Storefront in Olympic Oaks Village

12107-12129 Manchester Rd, Des Peres, MO 63131

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1,400 sqft

25,971 VPD

Storefront space within Olympic Oaks Village, anchored by T.J. Maxx and ALDI, with renovated facade and signalized access.

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Medical Office Space Available

1000 Des Peres Rd, Des Peres, MO

Gross

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13,515 sqft 5.87 acres

Medical office space for lease in Des Peres, Missouri.

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7 active listings match your search: For lease in Des Peres, MO. Based on your search, we've also compiled 8 Potential Opportunities for your consideration: 4 spaces in nearby cities and 4 properties for sale.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Class A Atrium Office Building

Saint Louis, MO 63131

Full service Class A

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9–15 people 1 space 2,319 sqft

Highway access

Class A atrium office building in a park-like setting with free surface parking and easy interstate access.

Atrium Park-like setting Free surface parking

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Retail Storefront with Patio Potential

11768 Manchester Rd, Saint Louis, MO 63131

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5,460 sqft

Retail storefront on signalized access with prominent Manchester Road visibility and patio potential.

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Office Building for Lease

13537 Barrett Pkwy Dr., Ballwin, MO 63021

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159–266 people 6 spaces 39,977 sqft Built 2026

For-lease office building totaling 39,977 square feet in Ballwin, Missouri.

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Ballwin Office Space Available

13545 Barrett Pkwy Dr., Ballwin, MO 63021

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52–88 people 5 spaces 13,224 sqft Built 2026

Office building with 13,224 square feet available for lease.

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Similar Spaces for Sale in Des Peres, MO

Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

Two-Level Shopping Center

13016 Manchester Road, Des Peres, MO 63131

$1,100,000

7,200 sqft

Retail property with separate upper- and lower-level units and Manchester Road frontage.

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10-Unit Retail Building

13016 Manchester Road, Des Peres, MO 63131

$1,100,000

0.09 AC lot

Two-level retail configuration with central air and durable brick-and-concrete construction.

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Multi-Unit Retail Building

13008 MANCHESTER RD, Des Peres, MO 63122

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7,200 sqft

The property carries C-1 zoning and includes retail space along Manchester Road.

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Commercial Land For Sale

12030 Manchester Rd, Des Peres, MO 63131

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2,250 sqft

Commercial land available for sale.

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Des Peres, MO Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in Des Peres, MO with 7 listings featured on our commercial real estate exchange. The current inventory includes 32,220 square feet of properties with an estimated lease value of $32.50.

Estimated lease rates for Commercial real estate in Des Peres, MO average $32.50 SF/Yr.