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    South Portland, ME Commercial Real Estate for Lease

    60 results
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    Class A Office Space Available
    Contact for pricing

    Class A Office Space Available

    778 Main St, South Portland, ME 04106

    Class A office building with ample parking and professional landscaping.

    • Prime location on Route One, minutes from Portland, Maine Mall, and Portland Jetport.
    • Easy access to Maine Turnpike and I‑295.
    • Ample parking and professional landscaping.
    • Class A office building.
    • Join esteemed tenants like Boston IVF and Health Markets.
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    South Portland Retail/Office Opportunity
    Contact for pricing
    11,890 SF

    South Portland Retail/Office Opportunity

    264 Gorham Rd, South Portland, ME 04106

    Modern, adaptable space in high-traffic Maine Mall area.

    • Prime location in the Maine Mall retail trade area with high visibility.
    • Easy access from I‑95 and I‑295.
    • Newer construction (built in 2019).
    • Adaptable space suitable for retail or traditional office uses.
    • Large pylon sign on Gorham Road.
    Updated: Sep 23, 2025
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    Freestanding Building at Cash Corner
    Contact for pricing
    1,440 SF

    Freestanding Building at Cash Corner

    Freestanding building in high-traffic area with parking and yard space.

    1422 Broadway, South Portland, ME 04106
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    Industrial Space with LED Lighting
    $8 SF/Yr
    28,800 SF

    Industrial Space with LED Lighting

    28,800+/- sq ft industrial space for lease.

    155 Rumery St, South Portland, ME 04106
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    Restaurant/Retail Space For Sublease
    Contact for pricing
    2,647 SF

    Restaurant/Retail Space For Sublease

    2,647± SF restaurant/retail space available for sublease.

    185 Cottage Rd, South Portland, ME 04106
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    Retail Space in South Portland
    Contact for pricing

    Retail Space in South Portland

    Retail space available in South Portland's premier shopping center.

    333 Clarks Pond Pkwy, South Portland, ME 04106
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    Retail Space Near Maine Mall
    Contact for pricing
    1,054 SF

    Retail Space Near Maine Mall

    Retail space with high visibility and ample parking available for lease.

    29 Western Ave, South Portland, ME 04106
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    Retail Space in Cornerbrook Plaza
    Contact for pricing
    12,808 SF

    Retail Space in Cornerbrook Plaza

    High-performing retail center with flexible space and excellent accessibility.

    343 Gorham Rd, South Portland, ME 04106
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    Office Space in John Roberts
    Contact for pricing
    10,000 SF

    Office Space in John Roberts

    Class A office space available for rent in South Portland.

    9 Donald B Dean Dr, South Portland, ME 04106
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    Commercial Zoned Property For Sale
    Contact for pricing

    Commercial Zoned Property For Sale

    Commercial zoned property ideal for contractor, roofer, or storage.

    179 Lincoln St, South Portland, ME 04106
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    Class A Office/Medical Building
    Contact for pricing
    5,530 SF

    Class A Office/Medical Building

    Class A office/medical building with suites available for lease.

    175 Running Hill Rd, South Portland, ME 04106
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    South Portland Industrial/Flex Space
    Contact for pricing
    2,400 SF

    South Portland Industrial/Flex Space

    2,400± SF industrial/flex space for lease in South Portland.

    1 Runway Rd, South Portland, ME 04106
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    South Portland Office Space Available
    Contact for pricing
    6,321 SF

    South Portland Office Space Available

    Office space for lease near Maine Mall and Portland Jetport.

    311 Darling Ave, South Portland, ME 04106
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    Class-A Office Suite For Lease
    Contact for pricing
    5,121 SF

    Class-A Office Suite For Lease

    Full-floor office suite in South Portland's Maine Mall area.

    30 Long Creek Dr, South Portland, ME 04106
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    Mallside Plaza Retail Space
    Contact for pricing
    98,401 SF

    Mallside Plaza Retail Space

    Prime South Portland retail/restaurant opportunity.

    198 Maine Mall Rd, South Portland, ME 04106
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    Prime Commercial Space - Broadway
    $15 SF/Yr
    21,000 SF

    Prime Commercial Space - Broadway

    Retail, warehouse, office space available.

    2325 Broadway, South Portland, ME 04106
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    South Portland Industrial Flex Space
    Contact for pricing
    1,875 SF

    South Portland Industrial Flex Space

    Flexible industrial space in South Portland, minutes from I-295.

    130 Thadeus St, South Portland, ME 04106
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    Retail/Office Space For Lease
    Contact for pricing
    1,700 SF

    Retail/Office Space For Lease

    Retail/office space in high-traffic South Portland location.

    209 Western Ave, South Portland, ME 04106
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    Jetport Plaza: Retail Space Available
    $10 SF/Yr
    100,982 SF

    Jetport Plaza: Retail Space Available

    Prime South Portland retail center, 100,982 sqft.

    443 Western Ave, South Portland, ME 04106
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    Gorham Road Retail Space
    $28 SF/Yr
    30,000 SF

    Gorham Road Retail Space

    Prime South Portland Retail Opportunity

    430 Gorham Rd, South Portland, ME 04106
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    South Portland Medical Office Building
    $26 SF/Yr
    17,071 SF

    South Portland Medical Office Building

    Prime Medical Office Space Available

    244 Western Ave, South Portland, ME 04106
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    Updated Medical Spa Space Available
    Contact for pricing
    4,200 SF

    Updated Medical Spa Space Available

    Recently updated medical spa, salon, or medical space for lease.

    198 Maine Mall Rd, South Portland, ME 04106
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    Industrial Building Near Maine Mall
    Contact for pricing
    4,800 SF

    Industrial Building Near Maine Mall

    5,700± SF industrial building with office space for lease.

    2092 Broadway, South Portland, ME 04106
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    South Portland Warehouse Space For Lease
    $14 SF/Yr
    42,000 SF

    South Portland Warehouse Space For Lease

    Food-focused industrial space available.

    95-97 Darling Ave, South Portland, ME 04106
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    South Portland, ME Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in South Portland, ME with 70 listings featured on our commercial real estate exchange. The current inventory includes 40,697,367,480 square feet of properties with an estimated lease value of $435 /Mo.

    Estimated lease rates for Commercial real estate in South Portland, ME begin at $7 SF/Yr, with an average of $16 SF/Yr and extend to $28 SF/Yr.
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