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    Port St Lucie, FL Commercial Real Estate for Lease

    79 results
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    Professional Office Space Available
    $2,287 / Mo
    998 SF

    Professional Office Space Available

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952

    Class A office suite with private offices and open space.

    • Class A Office Space: Enjoy a high‑quality, professional office environment.
    • Convenient Location: Benefit from close proximity to HCA and major highways.
    • Functional Layout: Features 3 private offices and an open workspace.
    • Accessibility: Located on the 2nd floor with elevator access.
    • Ample Parking: Ensures convenient parking for employees and clients.
    Updated: May 18, 2025
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    Freestanding Building on US Highway
    $26 SF/Yr
    46,609 SF

    Freestanding Building on US Highway

    10244 S Us Highway 1, Port St Lucie, FL 34952

    General Commercial zoning ideal for retail, medical, or restaurant.

    • High‑traffic location on US Hwy 1 with 35,500 AADT and 187' frontage.
    • General Commercial zoning suitable for retail, medical, restaurant, or professional use.
    • Ideal sub‑lease option with two separate entrances.
    • Existing electronic and media infrastructure wiring throughout.
    • Modular interior wall system allows for easy reconfiguration.
    Updated: Nov 16, 2025
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    Medical Office Space For Rent
    $24 SF/Yr
    998 SF

    Medical Office Space For Rent

    Updated medical office space available for rent in Port St. Lucie.

    1801 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Salon Suite in Port St. Lucie
    $3,500 / Mo
    125,884 SF

    Salon Suite in Port St. Lucie

    Turn-key salon suite in a busy plaza.

    302 SW Tulip Blvd, Port St Lucie, FL 34953
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    Port St. Lucie Executive Office
    $1,527 / Mo
    998 SF

    Port St. Lucie Executive Office

    Executive office suite in Port St. Lucie medical corridor.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Freestanding Office Space Available
    $25 SF/Yr

    Freestanding Office Space Available

    Office space for rent in high-visibility freestanding building.

    1399 SE Port St Lucie Blvd, Port St Lucie, FL 34952
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    Executive Office Suites For Rent
    $500 / Mo
    231 SF

    Executive Office Suites For Rent

    Executive office suites available for lease in Port St. Lucie.

    951 SW Country Clb Dr, Port St Lucie, FL
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    Port St. Lucie Retail Center
    $23 SF/Yr

    Port St. Lucie Retail Center

    Retail strip center with high-traffic exposure on US-1 Highway.

    7630 S Us Highway 1, Port St Lucie, FL 34952
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    Retail Space in St Lucie
    Contact for pricing
    1,000 SF

    Retail Space in St Lucie

    Retail space available in a busy shopping center.

    1315-1367 St Lucie Blvd W, Port St Lucie, FL
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    Retail Space Available For Rent
    $1,360 / Mo
    650 SF

    Retail Space Available For Rent

    Retail space with storage/office in high-traffic area.

    10502-10558 S Us Highway 1, Port St Lucie, FL 34952
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    St. Lucie West Office Space
    $23 SF/Yr
    2,021 SF

    St. Lucie West Office Space

    Professional and medical office space in St. Lucie West.

    1660 SW St Lucie Blvd W, Port St Lucie, FL
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    Port St. Lucie Distribution Space
    $11 SF/Yr
    115,635 SF

    Port St. Lucie Distribution Space

    Distribution/industrial space in Tradition, Port St. Lucie, Florida.

    12050 SW Tom Mackie Blvd, Port St Lucie, FL
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    Retail Space in Growing Community
    Contact for pricing
    1,814 SF

    Retail Space in Growing Community

    Retail space near new developments in Tradition, Port St. Lucie.

    10400 SW Discovery Way, Port St Lucie, FL
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    St. Lucie West Professional Office
    $23 SF/Yr
    4,964 SF

    St. Lucie West Professional Office

    Professional office space in a convenient St. Lucie West location.

    537 NW Lk Whitney Pl, Port St Lucie, FL
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    Retail Space in Renovated Center
    $22 SF/Yr
    900 SF

    Retail Space in Renovated Center

    Retail space available in a recently renovated shopping center.

    3253-3261 SW Prt St, Port St Lucie, FL
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    Retail/Office Space on US Highway
    $12 SF/Yr
    19,008 SF

    Retail/Office Space on US Highway

    Retail, office, or medical spaces with high visibility.

    10600-10642 South Federal Hwy, Port St Lucie, FL 34952
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    Tradition Village Square Office Space
    $27 SF/Yr
    28,959 SF

    Tradition Village Square Office Space

    Office space for lease in vibrant Tradition community.

    10801 SW Tradition Sq, Port St Lucie, FL 34987
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    Versatile Property Near Florida Turnpike
    $3,300 / Mo

    Versatile Property Near Florida Turnpike

    2,500 sq ft property suitable for residential or commercial use.

    1892 SW Biltmore St, Port St Lucie, FL 34984
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    Office Space Available For Rent
    Contact for pricing
    2,750 SF

    Office Space Available For Rent

    Office space available for rent in Port St. Lucie, FL.

    451 SW Bethany Dr, Port St Lucie, FL
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    Professional Office Space Available
    $1,750 / Mo
    450 SF

    Professional Office Space Available

    Office sublet with four private offices, shared amenities, utilities included.

    1800-1900 SE Prt St, Port St Lucie, FL
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    Port St. Lucie Flex Space
    $15 SF/Yr
    1,250 SF

    Port St. Lucie Flex Space

    Flex space in centrally located industrial park for lease.

    1337-1344 S Macedo Blvd, Port St Lucie, FL
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    New Professional Office Space Available
    $25 SF/Yr
    4,130 SF

    New Professional Office Space Available

    New construction office space for lease in Port St. Lucie.

    1380 SW Import Dr, Port St Lucie, FL
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    Anchored Retail Center For Lease
    Contact for pricing

    Anchored Retail Center For Lease

    Retail space available in Publix and Ace Hardware anchored center.

    7576 Us 1, Port St Lucie, FL
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    Retail Space in Growing Community
    Contact for pricing
    14,400 SF

    Retail Space in Growing Community

    Retail space near new developments in Tradition, Port St. Lucie.

    10340 SW Discovery Way, Port St Lucie, FL
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    Port St Lucie, FL Commercial Real Estate Leasing Opportunities Market Analysis

    Explore Commercial Real Estate leasing options in Port St Lucie, FL with 101 listings featured on our commercial real estate exchange. The current inventory includes 30,476,461,937 square feet of properties with an estimated lease value of $960 /Mo.

    Estimated lease rates for Commercial Real Estate in Port St Lucie, FL begin at $2 SF/Yr, with an average of $21 SF/Yr and extend to $46 SF/Yr.

    In Port St Lucie, FL, current lease rates show:

    • Office Properties & Spaces positioned at $23
    • Office space measuring $22
    • Retail properties assessed at $21
    • Medical offices calculated at $24
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    Browse Commercial real estate for Lease Near Port St Lucie, FL

    Popular Searches in Port St Lucie, FL

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    Most Searched ZIP Codes in Port St Lucie, FL

    • 34952
    • 34953
    • 34987
    • 34984
    • 34986
    • 34983

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