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    Port St Lucie, FL Commercial Real Estate for Lease

    71 results
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    Freestanding Building on US Highway
    $26 SF/Yr
    46,609 SF

    Freestanding Building on US Highway

    10244 S Us Highway 1, Port St Lucie, FL 34952

    General Commercial zoning ideal for retail, medical, or restaurant.

    • High‑traffic location on US Hwy 1 with 35,500 AADT and 187' frontage.
    • General Commercial zoning suitable for retail, medical, restaurant, or professional use.
    • Ideal sub‑lease option with two separate entrances.
    • Existing electronic and media infrastructure wiring throughout.
    • Modular interior wall system allows for easy reconfiguration.
    Updated: Nov 16, 2025
    View details
    Medical Office Space For Rent
    $24 SF/Yr
    998 SF

    Medical Office Space For Rent

    1801 SE Hillmoor Dr, Port St Lucie, FL 34952

    Updated medical office space available for rent in Port St. Lucie.

    • Updated with new vinyl plank flooring, paint, and cabinetry.
    • Features 3 exam rooms and 1 lab/kitchen.
    • Includes 2 bathrooms and 2 business offices.
    • Equipped with central heating and air conditioning.
    • Built in 1996 with block and concrete construction.
    Updated: Aug 31, 2025
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    Port St. Lucie Executive Office
    $1,527 / Mo
    998 SF

    Port St. Lucie Executive Office

    Executive office suite in Port St. Lucie medical corridor.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Professional Office Space Available
    $2,287 / Mo
    998 SF

    Professional Office Space Available

    Class A office suite with private offices and open space.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Professional Office Suite Available
    $2,287 / Mo

    Professional Office Suite Available

    Class A office suite with private offices and open space.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    Executive Office Suites For Rent
    $500 / Mo
    231 SF

    Executive Office Suites For Rent

    Executive office suites available for lease in Port St. Lucie.

    951 SW Country Clb Dr, Port St Lucie, FL
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    Retail Space in Publix-Anchored Center
    $30 SF/Yr
    563 SF

    Retail Space in Publix-Anchored Center

    Retail space available in a busy, renovated shopping center.

    9020-9164 Us Highway 1, Port St Lucie, FL 34952
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    Freestanding Building on US Highway
    $26 SF/Yr

    Freestanding Building on US Highway

    Versatile commercial space ideal for retail, medical, or restaurant use.

    10244 S Us Highway 1, Port St Lucie, FL 34952
    View details
    Port St. Lucie Retail Center
    $23 SF/Yr

    Port St. Lucie Retail Center

    Retail strip center with high-traffic exposure on US-1 Highway.

    7630 S Us Highway 1, Port St Lucie, FL 34952
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    Commercial Plaza in Growing Tradition
    $40 SF/Yr
    2,122 SF

    Commercial Plaza in Growing Tradition

    Future commercial plaza in rapidly growing Tradition area.

    11650 SW Vlg Pkwy, Port St Lucie, FL
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    St. Lucie West Office Space
    $23 SF/Yr
    2,021 SF

    St. Lucie West Office Space

    Professional and medical office space in St. Lucie West.

    1660 SW St Lucie Blvd W, Port St Lucie, FL
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    Retail Space For Lease
    $24 SF/Yr
    1,600 SF

    Retail Space For Lease

    Retail space available for lease in Port St. Lucie.

    10921-10941 Us 1, Port St Lucie, FL
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    Port St. Lucie Warehouse Space
    $1,331 / Mo

    Port St. Lucie Warehouse Space

    940 SF warehouse with office and loft for rent.

    1576 South Niemeyer Cir, Port St Lucie, FL 34952
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    Retail Space on Village Parkway
    Contact for pricing
    8,960 SF

    Retail Space on Village Parkway

    Versatile retail spaces in rapidly growing Port St. Lucie, Florida.

    10704 SW Vlg Pkwy, Port St Lucie, FL
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    Prime Retail Outparcel For Lease
    Contact for pricing
    10,000 SF

    Prime Retail Outparcel For Lease

    Retail outparcel for lease in high-traffic Port St. Lucie.

    10400 S Us Highway 1, Port St Lucie, FL 34952
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    St. Lucie West Office Building
    $35 SF/Yr
    18,000 SF

    St. Lucie West Office Building

    Office building in a fast-growing area with excellent visibility.

    9265 SW Commerce Ctr Dr, Port St Lucie, FL
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    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Freestanding Restaurant Building For Rent
    Contact for pricing
    3,000 SF

    Freestanding Restaurant Building For Rent

    3,000 SF newly renovated restaurant space with drive-through.

    6598 Kitterman Rd, Port Saint Lucie, FL 34952
    View details
    St. Lucie Oaks Executive Suites
    $23 SF/Yr
    13,894 SF

    St. Lucie Oaks Executive Suites

    Class A Office Space in Port St. Lucie

    7041 Us Highway 1, Fort Pierce, FL 34952
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    Port Saint Lucie Office Space
    Contact for pricing
    13,029 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie, FL.

    900 E Prima Vista Blvd, Port Saint Lucie, FL 34952
    View details
    Commercial Land Leasing Opportunity
    Contact for pricing

    Commercial Land Leasing Opportunity

    Retail strip center development with leasing opportunities available.

    507 W Midway Rd, Fort Pierce, FL 34982
    View details

    Explore Similar Spaces for Sale in Port St Lucie, FL

    Consider Similar Space for Sale. We found 121 Spaces in Nearby Locations matching your search parameters.

    Port St. Lucie Commercial Lots
    $285,000
    0.73 Acres

    Port St. Lucie Commercial Lots

    Three commercial lots available in Port St. Lucie, Florida.

    4123 SW Port St Lucie Blvd, Port St Lucie, FL 34953
    View details
    Resort-Style Land with Tiki
    Pending
    $350,000
    0.08 Acres

    Resort-Style Land with Tiki

    Luxury land with golf course view and outdoor entertaining space.

    425 NW Chipshot Ln, Port St Lucie, FL 34986
    View details
    Port St Lucie Showroom/Warehouse
    $235,000
    0.02 Acres

    Port St Lucie Showroom/Warehouse

    Turnkey showroom/warehouse in established Port St. Lucie commercial district.

    1459 SE Village Green Dr, Port St Lucie, FL 34952
    View details
    Luxury RV Lot on Golf Course
    $350,000
    0.08 Acres

    Luxury RV Lot on Golf Course

    Impeccably designed RV lot with tiki structure and outdoor kitchen.

    375 NW Boundary Dr, Port St Lucie, FL 34986
    View details
    Tiki Lot in Port St. Lucie
    $425,000
    0.07 Acres

    Tiki Lot in Port St. Lucie

    Turnkey tropical retreat with water views and modern amenities.

    509 NW Chipshot Ln, Port St Lucie, FL 34986
    View details
    Port St Lucie Land with Amenities
    $300,000
    0.07 Acres

    Port St Lucie Land with Amenities

    Land with tiki hut, kitchen, bar, and golf course views.

    421 NW Chipshot Ln, Port St Lucie, FL 34986
    View details
    Golf Course View Corner Lot
    $275,000
    3,757 SF

    Golf Course View Corner Lot

    Oversized corner lot with golf course and lake views.

    426 NW Chipshot Ln, Port St Lucie, FL 34986
    View details
    Luxury RV Lot with Tiki
    $329,000
    0.07 Acres

    Luxury RV Lot with Tiki

    Move-in-ready RV lot with tiki, golf course, and lake views.

    485 NW Boundary Dr, Port St Lucie, FL 34986
    View details

    Port St Lucie, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Port St Lucie, FL with 192 listings featured on our commercial real estate exchange. The current inventory includes 23,566,516,313 square feet of properties with an estimated lease value of $605 /Mo.

    Estimated lease rates for Commercial real estate in Port St Lucie, FL begin at $2 SF/Yr, with an average of $21 SF/Yr and extend to $40 SF/Yr.
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