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    Columbia County, FL Commercial Real Estate for Lease

    8 results
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    Spacious Office with Flexible Layout
    $5,036 /Mo
    4,029 SF

    Spacious Office with Flexible Layout

    164 NW Madison Street, Lake City, FL 32055

    Adaptable office space suitable for diverse business applications.

    • Expansive 4,029 SqFt open area with exquisite lighting and crown molding.
    • Flexible layout suitable for various business needs and potential to be split into smaller suites.
    • Multiple office areas: reception/office area, left‑side offices, and 4 rear office areas.
    • Includes 2 private restrooms and access to 2 public restrooms in the common area.
    • Water and trash collection included in the lease.
    Updated: Mar 24
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    Former Restaurant Building on US-90
    Contact for pricing

    Former Restaurant Building on US-90

    Lake City, FL 32055

    4,153 SF former restaurant on 1.38 acres available for rent.

    • High‑traffic location at a fully signalized intersection on US‑90.
    • Former restaurant building with 4,153 SF on 1.38 acres.
    • Located across from top‑performing Zaxby's, Chick‑fil‑A, and Burger King locations in Florida.
    • Proximity to a high‑performing Walmart Supercenter (top 95% nationally).
    • Close proximity to Interstate‑75.
    Updated: Nov 25, 2025
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    Updated Office Condo For Rent
    $27 SF/Yr
    1,801 SF

    Updated Office Condo For Rent

    Updated office condo with modern finishes, ideal for medical use.

    1140 SW Bascom Norris Dr, Lake City, FL
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    Retail Space on Duval Street
    $10,500 /Mo

    Retail Space on Duval Street

    Commercial unit for rent in high-traffic Duval Street corridor.

    1780 E Duval St Ste 120, Lake City, FL 32055
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    Retail Space in Lake City
    Contact for pricing
    2,377 SF

    Retail Space in Lake City

    Grocery-anchored neighborhood center along US Highway 90.

    255 NW Commons Loop, Lake City, FL
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    Retail Space in High Traffic Area
    $9 SF/Yr
    16,731 SF

    Retail Space in High Traffic Area

    Retail space available in a desirable, high-traffic location.

    2311 West US Highway 90, Lake City, FL
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    Commercial Lots for Ground Lease
    Contact for pricing
    1,650 SF

    Commercial Lots for Ground Lease

    Multiple lots available in new commercial development.

    FL-47, Lake City, FL 32024
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    Retail and Office Space Available
    Contact for pricing

    Retail and Office Space Available

    Suites available in plaza with national tenants.

    879 SW Main Blvd, Lake City, FL 32025
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    Based on your search, we've compiled 120 Potential Opportunities for your consideration. Besides 8 Active listings in Columbia County, FL, we suggest exploring alternatives. Similar 112 Properties for Sales.

    Explore Similar Spaces for Sale in Columbia County, FL

    Consider Similar Space for Sale. We found 112 Spaces matching your search parameters.

    Lake City Office Building For Sale
    $350,000
    1,823 SF

    Lake City Office Building For Sale

    Class B office building with expansion and investment potential.

    229 SW MAIN BOULEVARD, Lake City, FL 32025
    View details
    Lake City Office Space Available
    $198,654
    1,529 SF

    Lake City Office Space Available

    Professional office space with multiple offices, conference room, and kitchen.

    654 BAYA DR, Lake City, FL 32025
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    Lake City Commercial Aviation Land
    $300,000
    1.70 Acres

    Lake City Commercial Aviation Land

    Commercial land in North Florida Airpark community, easy I-75 access.

    TBD 5 & 6 POBEREZNY GLN, Lake City, FL 32025
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    7.64 Acres Commercial Land
    $699,000
    7.64 Acres

    7.64 Acres Commercial Land

    Commercial zoned land in a growing area with road frontage.

    782 SW SISTERS WELCOME ROAD, Lake City, FL 32025
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    Recreational Property Bordering National Forest
    $895,000
    1,322 SF

    Recreational Property Bordering National Forest

    105-acre recreational property near Lake City, Florida.

    1317 Northeast Drew Road, Lake City, FL 32055
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    Lake City Commercial Aviation Lot
    $150,000
    0.50 Acres

    Lake City Commercial Aviation Lot

    Commercial lot suitable for aviation or other commercial businesses.

    LOT 6 SW POBEREZNY GLEN, Lake City, FL 32025
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    Lake City Professional Office
    $295,000
    1,208 SF

    Lake City Professional Office

    Commercial office building with reception, exam rooms, and bathroom.

    1166 SW MAIN BLVD, Lake City, FL 32025
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    Commercial Lot in Lake City
    $350,000
    2.13 Acres

    Commercial Lot in Lake City

    2.13-acre commercial lot suitable for various business types.

    1563 SW CENTURY GLN (LOT 2), Lake City, FL 32025
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    Lake City Commercial Lot
    $150,000
    0.50 Acres

    Lake City Commercial Lot

    Commercial lot suitable for aviation or other business.

    LOT 5 SW POBEREZNY GLEN, Lake City, FL 32025
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    Lake City Industrial Property
    $699,000
    15,000 SF

    Lake City Industrial Property

    15,000 SF industrial property on 1.72 acres in Lake City.

    3887 E US HIGHWAY 90, Lake City, FL 32055
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    Lake City Commercial Investment Property
    $870,000
    8,800 SF

    Lake City Commercial Investment Property

    8,800 sq ft building leased to daycare center.

    258 SW Columbia Avenue, Lake City, FL 32025
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    Wooded Acreage Near Santa Fe River
    $450,000
    20.00 Acres

    Wooded Acreage Near Santa Fe River

    20-acre wooded property near Santa Fe River, Fort White, FL.

    290 SW RATTLESNAKE GLEN, Fort White, FL 32038
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    Lake City Commercial Lot
    $200,000
    2.22 Acres

    Lake City Commercial Lot

    Commercial lot in Lake City, Florida, with diverse business potential.

    1563 SW CENTURY GLN (LOT 3), Lake City, FL 32025
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    Rare Land with Barn and Utilities
    $435,000
    45.00 Acres

    Rare Land with Barn and Utilities

    45-acre property with pasture, woods, barn, and utilities.

    237 NW LOWER SPRINGS ROAD, Lake City, FL 32055
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    Retail Property Near Lake City Mall
    $1,800,000
    3,607 SF

    Retail Property Near Lake City Mall

    Retail space near Walmart and Lowe's, formerly a restaurant.

    3585 NW BASCOM NORRIS, Lake City, FL 32055
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    Lake City Commercial Lot Available
    $400,000
    2.04 Acres

    Lake City Commercial Lot Available

    Prime commercial lot in a rapidly developing area.

    TBD SW COMMERCE DR, Lake City, FL 32025
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    Columbia County, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Columbia County, FL with 8 listings featured on our commercial real estate exchange. The current inventory includes 939,153,600 square feet of properties with an estimated lease value of $181 SF/Yr.

    Estimated lease rates for Commercial real estate in Columbia County, FL begin at $9 SF/Yr, with an average of $60 SF/Yr and extend to $157 SF/Yr.
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