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    Lake City, FL Commercial Real Estate for Lease

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    High Springs, FL Branford, FL Coral Gables, FL
    8 listings
    Industrial Warehouse with Loading Yard
    Contact for pricing
    Industrial Warehouse with Loading Yard

    2249 Southeast Baya Drive, Lake City, FL 32025

    Functional warehouse layout with large roll-up doors and an outdoor yard option for loading, storage, and operations.
    • 8,000 SF warehouse available for lease
    • 1981‑built warehouse with large roll‑up doors
    • Power included with lighting
    • Private restroom with sink plus separate wash sink
    • Large open interior area with concrete pad in front for loading and unloading
    Updated: Jun 1
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    Former Restaurant Building on US-90
    Contact for pricing
    Former Restaurant Building on US-90

    Lake City, FL 32055

    4,153 SF former restaurant on 1.38 acres available for rent.
    • High‑traffic location at a fully signalized intersection on US‑90.
    • Former restaurant building with 4,153 SF on 1.38 acres.
    • Located across from top‑performing Zaxby's, Chick‑fil‑A, and Burger King locations in Florida.
    • Proximity to a high‑performing Walmart Supercenter (top 95% nationally).
    • Close proximity to Interstate‑75.
    Updated: Nov 25, 2025
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    Retail Space on Duval Street
    $10,500/Mo
    Retail Space on Duval Street

    Commercial unit for rent in high-traffic Duval Street corridor.

    1780 E Duval St Ste 120, Lake City, FL 32055

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    Retail Space in Lake City
    Contact for pricing
    2,377 SF
    Retail Space in Lake City

    Grocery-anchored neighborhood center along US Highway 90.

    255 NW Commons Loop, Lake City, FL

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    Retail Space in High Traffic Area
    $9 SF/Yr
    16,731 SF
    Retail Space in High Traffic Area

    Retail space available in a desirable, high-traffic location.

    2311 West US Highway 90, Lake City, FL

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    Former Restaurant Site For Rent
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    Former Restaurant Site For Rent

    Former restaurant site in Lake City retail corridor.

    2281 W US Hwy 90, Lake City, FL 32055

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    Commercial Lots for Ground Lease
    $1.84 SF/Yr
    1,650 SF
    Commercial Lots for Ground Lease

    Multiple lots available in new commercial development.

    FL-47, Lake City, FL 32024

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    Retail Space in Lake City
    Contact for pricing
    Retail Space in Lake City

    Retail space available in Lake City Mall on US Hwy 90.

    2469 W US Hwy 90, Lake City, FL 32055

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    Based on your search, we've compiled 120 Potential Opportunities for your consideration. Besides 8 Active listings in Lake City, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 108 Properties for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Retail Space in High Springs
    Contact for pricing
    3,614 SF
    Retail Space in High Springs

    Anchor and former liquor store space available for lease.

    20303 US Hwy 441, High Springs, FL 32643

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    Retail Center Anchored by Big Lots
    Contact for pricing
    36,464 SF
    Retail Center Anchored by Big Lots

    106,258 SF retail center in established location.

    1520 Ohio Ave S, Live Oak, FL

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    Retail Outparcels in Live Oak
    Contact for pricing
    1,400 SF
    Retail Outparcels in Live Oak

    Two outparcels available in Publix-anchored development, Live Oak.

    2215 Ohio Ave N, Live Oak, FL

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    Retail Space Available For Rent
    Contact for pricing
    13,280 SF
    Retail Space Available For Rent

    Retail spaces available, ranging from 900 to 13,280 square feet.

    20303 US-441, High Springs, FL 32643

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    Similar Spaces for Sale in Lake City, FL

    Consider Similar Space for Sale. We found 108 Spaces matching your search parameters.

    Highway Frontage Commercial Property
    $610,000
    3,168 SF
    Highway Frontage Commercial Property

    3,168 sq ft commercial property on 1.501 acres.

    2832 SW MAIN BLVD., Lake City, FL 32025

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    Convenience Store and Gas Station
    $850,000
    1,800 SF
    Convenience Store and Gas Station

    Single-story convenience store and gas station on a visible site near a major highway interchange.

    13769 S US HWY 441, Lake City, FL 32025

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    Single-Story Medical Office Building
    $275,000
    1,208 SF
    Single-Story Medical Office Building

    Single-story office suited for medical use, featuring a reception area, multiple exam rooms, and a private breakroom.

    1166 SW MAIN BLVD, Lake City, FL 32025

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    Commercial Property in Lake City
    $795,000
    0.39 Acres
    Commercial Property in Lake City

    Commercial property suitable for various uses, formerly a restaurant.

    535 SW MAIN BLVD, Lake City, FL 32024

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    Lake City Office Space Available
    $198,654
    1,529 SF
    Lake City Office Space Available

    Professional office space with multiple offices, conference room, and kitchen.

    654 BAYA DR, Lake City, FL 32025

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    Lake City Industrial Property
    $699,000
    15,000 SF
    Lake City Industrial Property

    15,000 SF industrial property on 1.72 acres in Lake City.

    3887 E US HIGHWAY 90, Lake City, FL 32055

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    Retail Property Near Lake City Mall
    $1,800,000
    3,607 SF
    Retail Property Near Lake City Mall

    Retail space near Walmart and Lowe's, formerly a restaurant.

    3585 NW BASCOM NORRIS, Lake City, FL 32055

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    Prime Commercial Land on Highway
    $1,250,000
    3,144 SF
    Prime Commercial Land on Highway

    5.36-acre commercial land with high-visibility frontage on W US Highway.

    4967 W US HIGHWAY 90, Lake City, FL 32055

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    Recreational Property Bordering National Forest
    $869,000
    1,322 SF
    Recreational Property Bordering National Forest

    105-acre recreational property near Lake City, Florida.

    1317 Northeast Drew Road, Lake City, FL 32055

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    Lake City Commercial Investment Property
    $870,000
    8,800 SF
    Lake City Commercial Investment Property

    8,800 sq ft building leased to daycare center.

    258 SW Columbia Avenue, Lake City, FL 32025

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    Versatile Commercial Asset with Airbnb Units
    $2,975,000
    26,000 SF
    Versatile Commercial Asset with Airbnb Units

    Multi-functional commercial property with retail, industrial, and residential income.

    1524 NW Main Boulevard, Lake City, FL 32055

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    134 Acres of Florida Beauty
    $979,500
    2,250 SF
    134 Acres of Florida Beauty

    Expansive land with timber, hardwoods, creek, and pasture.

    000 SE CR 245A, Lake City, 32025

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    16.48 Acre Commercial Tract
    $3,000,000
    16.68 Acres
    16.48 Acre Commercial Tract

    16.48 acre commercial tract with high visibility and traffic.

    0 W W US HWY 90, Lake City, FL 32024

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    Lake City Commercial Aviation Lot
    $150,000
    0.50 Acres
    Lake City Commercial Aviation Lot

    Commercial lot suitable for aviation or other commercial businesses.

    LOT 6 SW POBEREZNY GLEN, Lake City, FL 32025

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    Lake City Commercial Lot
    $150,000
    0.50 Acres
    Lake City Commercial Lot

    Commercial lot suitable for aviation or other business.

    LOT 5 SW POBEREZNY GLEN, Lake City, FL 32025

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    Lake City Commercial Aviation Land
    $300,000
    1.70 Acres
    Lake City Commercial Aviation Land

    Commercial land in North Florida Airpark community, easy I-75 access.

    TBD 5 & 6 POBEREZNY GLN, Lake City, FL 32025

    View details

    Lake City, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Lake City, FL with 8 listings featured on our commercial real estate exchange. The current inventory includes 18,381 square feet of properties with an estimated lease value of $10 SF/Yr.

    Estimated lease rates for Commercial real estate in Lake City, FL begin at $1.84 SF/Yr, with an average of $5 SF/Yr and extend to $9 SF/Yr.
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