Simpsonville, SC Strip malls for Rent & Lease

Updated: Nov 21, 2025

Simpsonville Retail Space For Lease

721 SE Main Street, Simpsonville, SC 29680

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17,500 sqft

High traffic location: Situated off I‑385 and Fairview Rd with excellent visibility and accessibility.
Flexible zoning: Accommodates a variety of retail, medical, and service‑oriented uses.
Sub‑dividable space: Up to ±7,500 SF of retail space available, divisible for qualified users.
New construction: Delivered early 2026.
Strong accessibility: Full access from SE Main St. and secondary access via Powderhorn Rd.

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Based on your search, we've compiled 9 Potential Opportunities for your consideration. Besides 1 Active listings in Simpsonville, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 1 Properties for Sales.

Strip malls for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

New Retail Center in Travelers

6516 State Park Rd, Travelers Rest, SC 29690

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10,800 sqft

New retail strip center in Travelers Rest, South Carolina.

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End Cap Restaurant Retail Suite

6516 State Park Rd, Travelers Rest, SC 29690

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2,790 sqft

End cap restaurant space is available in a strip center with cold dark shell delivery and optional tenant improvements.

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Strip Mall Retail Space

101 Verdae Blvd, Greenville, SC 29607

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2,800 sqft

Retail strip mall space at 101 Verdae Blvd with strong area access to major Greenville roadways and interstate routes.

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Retail Space in Greenville Center

3619 Pelham Rd, Greenville, SC

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2,500 sqft 6.96 AC lot

Retail space available in busy Greenville shopping center.

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Similar Spaces for Sale in Simpsonville, SC

Consider Similar Space for Sale. We found 1 Spaces matching your search parameters.

Fully Leased Retail Strip Center

15 Ray E Talley Ct, Simpsonville, SC 29681

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6,300 sqft

Fully leased retail strip center anchored by Subway and Great Clips along Fairview Road.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Development-Ready Site in Moore, SC

5831 Reidville Road, Moore, SC 29369

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11.26 AC lot

11.26-acre commercial site in a high-growth area.

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Retail Strip Center Land Available

2409 West Russell Street, Sioux Falls, SD 57104

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0.71 acres of commercial land for retail strip center.

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Retail Strip Center Land

2800 South Ellis Road, Sioux Falls, SD 57106

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1.39 acres of commercial land for retail development.

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Simpsonville, SC Strip Malls for Lease

721 SE Main Street, Simpsonville, SC 29680