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    Hyannis, MA Retail Space for Lease

    10 results
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    Main Street Retail and Residence
    $46,200
    2,112 SF

    Main Street Retail and Residence

    547 Main St, Hyannis, MA 02601

    Prime Hyannis location with retail space and on-site residence.

    • Prime Main Street Hyannis location with high year‑round foot traffic and strong summer tourism.
    • Completely rebuilt from the studs out with new walls, ceilings, flooring, plumbing, electrical, HVAC, and finishes.
    • Rare combination of ground‑floor retail space with an on‑site, modern apartment.
    • Open, flexible retail layout with high ceilings and large display windows.
    • Ideal for owner‑operator with living space above the retail business.
    Updated: Jan 7
    View details
    Main Street Retail Opportunity
    $49,020
    2,228 SF

    Main Street Retail Opportunity

    615 Main St, Hyannis, MA 02601

    Prime retail or restaurant space in Hyannis, Massachusetts.

    • Prime location on historic Main Street in Hyannis, Cape Cod, with high car and foot traffic.
    • Versatile 2,200 sq ft space suitable for restaurant, retail, or office use.
    • Located in the Hyannis Main Street Business Improvement District (BID), promoting a clean, safe, and economically developed environment.
    • Walking distance to Nantucket Sound beaches and the Melody Tent.
    • Close proximity to Main Street attractions, Cape Cod Hospital, and ferry service to the islands.
    Updated: Dec 23, 2025
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    Downtown Hyannis Retail Space Available
    $2,325 / Mo
    16,184 SF

    Downtown Hyannis Retail Space Available

    900 SF open retail space on Main Street.

    357 Main St, Hyannis, MA 02601
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    Prime Hyannis Retail Space Available
    $2,475 / Mo
    1,188 SF

    Prime Hyannis Retail Space Available

    1,200 sq ft retail space in meticulously maintained complex.

    11 Enterprise Rd, Hyannis, MA 02601
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    Prime Retail Space in Hyannis
    $21 SF/Yr
    3,300 SF

    Prime Retail Space in Hyannis

    Spacious 3,300 SF retail space in downtown Hyannis.

    426 Main St, Hyannis, MA 02601
    View details
    Retail Space Available For Lease
    $5,999 / Mo
    4,200 SF

    Retail Space Available For Lease

    Retail space available for lease, totaling 4,200 square feet.

    431 Yarmouth Rd, Hyannis, MA 02601
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    Prime Retail Space on Main
    $3,998 / Mo
    2,175 SF

    Prime Retail Space on Main

    Retail space in bustling Hyannis 400 Block on Main.

    388-408 Main St, Hyannis, MA 02668
    View details
    Hyannis Retail Space Available
    $950 / Mo
    1,200 SF

    Hyannis Retail Space Available

    Retail space in busy strip mall off the highway.

    696-700 Yarmouth Rd, Hyannis, MA
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    Class A Business Bay
    $18 SF/Yr
    3,640 SF

    Class A Business Bay

    Immaculate industrial bay with high visibility and modern amenities.

    155 Rosary Ln, Hyannis, MA
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    Hyannis Plaza Retail Space
    $19 SF/Yr
    1,500 SF

    Hyannis Plaza Retail Space

    Retail unit in Hyannis Plaza with open floor plan.

    489 Bearses Way, Hyannis, MA
    View details
    Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 10 Active listings in Hyannis, MA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

    Explore Retail space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Retail Unit in Hyannis Plaza
    $2,438 / Mo
    1,500 SF

    Retail Unit in Hyannis Plaza

    Retail space for lease in Hyannis Plaza, Barnstable, MA.

    317 Falmouth Rd, Barnstable, MA 02630
    View details
    New Retail/Restaurant Space Available
    $33 SF/Yr
    4,533 SF

    New Retail/Restaurant Space Available

    New construction retail/restaurant space at Staples Plaza in Hyannis.

    378B Barnstable Rd, Barnstable, MA 02630
    View details
    West Yarmouth Retail Space Available
    $18 SF/Yr
    3,360 SF

    West Yarmouth Retail Space Available

    Retail space in historic building with ample parking.

    316 Yarmouth Rd, Yarmouth, MA 02673
    View details
    Yarmouth Retail Space Available
    Contact for pricing
    2,500 SF

    Yarmouth Retail Space Available

    Retail spaces for lease in grocery-anchored shopping center.

    5 Long Pond Dr, Yarmouth, MA 02664
    View details

    Explore Similar Spaces for Sale in Hyannis, MA

    Consider Similar Space for Sale. We found 5 Spaces in Nearby Locations matching your search parameters.

    Downtown Hyannis Mixed-Use Property
    $1,285,000
    4,032 SF

    Downtown Hyannis Mixed-Use Property

    Turnkey mixed-use property with buildable lot in downtown Hyannis.

    574 Main St, Hyannis, MA 02601
    View details
    Downtown Hyannis Two-Unit Building
    Pending
    $1,399,000
    5,348 SF

    Downtown Hyannis Two-Unit Building

    Two-unit building in downtown Hyannis with investment opportunity.

    328 Main St, Hyannis, MA 02601
    View details
    Historic Hyannis Main Street Property
    $574,900
    2,228 SF

    Historic Hyannis Main Street Property

    Prime location suitable for retail, restaurant, or office use.

    615-617 Main St, Hyannis, MA 02668
    View details
    Historic Hyannis Main Street Property
    $574,900

    Historic Hyannis Main Street Property

    2,200 SF space ideal for restaurant or retail.

    615 Main St, Hyannis, MA 02601
    View details
    Established Uniform Supply Business For Sale
    $849,000

    Established Uniform Supply Business For Sale

    Profitable uniform and equipment supplier serving first responders for 35+ years.

    11 Enterprise Rd, Hyannis, MA 02601
    View details

    Hyannis, MA Retail space Leasing Opportunities Market Analysis

    Explore Retail space leasing options in Hyannis, MA with 15 listings featured on our commercial real estate exchange. The current inventory includes 1,454,337,720 square feet of properties with an estimated lease value of $133 SF/Yr.

    Estimated lease rates for Retail space in Hyannis, MA begin at $1.72 SF/Yr, with an average of $16 SF/Yr and extend to $25 SF/Yr.
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    Browse Retail space for Lease Near Hyannis, MA

    Popular Searches in Hyannis, MA

    Most Searched ZIP Codes in Hyannis, MA

    • 02601
    • 02668

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