Port Isabel, TX Retail properties & Spaces for sale

Highway 100 Commercial Business Opportunity

$1,500,000

2,384 SF

Highway 100 Commercial Business Opportunity

321 Hwy 100, Port Isabel, TX 78578

Turnkey business on Highway 100 in Port Isabel for sale.

Two established businesses (liquor store and convenience store) included in the sale.
Prime commercial location on Highway 100 in Port Isabel.
Includes building, equipment, inventory, and business.
Drive‑through window for liquor store convenience.
Well‑established business with 40+ years of family operation.

Updated: Jan 1

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Multifaceted Coastal Investment Opportunity

$9,000,000

25,257 SF

Multifaceted Coastal Investment Opportunity

418 Hwy 100, Port Isabel, TX 78578

Hospitality, recreation, and lifestyle investment in desirable coastal Texas.

Multifaceted commercial property with hospitality, recreation, and lifestyle businesses.
Includes 24 hotel rooms, a fully occupied 12‑unit apartment complex, and a full‑service restaurant & bar with new equipment.
Features 28 boat slips with direct bay access and a gas pump station for boats.
Includes an additional 1.68‑acre commercial property used for RV and boat storage, generating excellent revenue.
Turnkey businesses with over $2 million in recent renovations.

Updated: Nov 6, 2025

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Based on your search, we've compiled 10 Potential Opportunities for your consideration. Besides 2 Active listings in Port Isabel, TX, we suggest exploring several alternatives: 4 properties in Nearby Cities, plus 4 Land Listings that present a potential for development.

Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

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14.41 Acres

Brownsville Commercial Land Trio

14 Acres, Prime Retail Location

3605 Fm 511, Brownsville, TX 78526

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$820,000

3,225 SF

Prime Padre Blvd Commercial Property

Versatile commercial property in a desirable South Padre Island location.

3812 Padre Blvd, South Padre Island, TX 78597

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Coastal Commercial Property on Padre Blvd

$1,200,000

1,867 SF

Coastal Commercial Property on Padre Blvd

Iconic commercial property on South Padre Island, ideal for retail.

5717 Padre Blvd, South Padre Island, TX 78597

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Contact for pricing

2,824 SF

Murphy USA Ground Lease For Sale

2,824 SF Murphy USA NNN ground lease in Brownsville, TX.

6101 Paredes Line Rd, Brownsville, TX 78526

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

$1,220,750

Waterfront Commercial Lots in Port Isabel

Prime waterfront property with Intracoastal Waterway access in Port Isabel.

Tbd Shr South, Port Isabel, TX 78578

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$265,000

Port Isabel Acreage Ready to Develop

1.30+/- acres, excellent location, high visibility, ready to develop.

47708 State Hwy 100 Hwy, Port Isabel, TX 78578

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$2,190,000

Waterfront Commercial Lots in Port Isabel

Waterfront property on Intracoastal Waterway, ideal for development.

Shore Dr South, Port Isabel, TX 78578

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$3,285,000

Waterfront Lots on Intracoastal Waterway

Waterfront property ideal for commercial or residential development in Port Isabel.

Shore Dr South, Port Isabel, TX 78578

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Port Isabel, TX Retail Properties & Spaces Investment Opportunities Market Analysis

Explore 2 retail properties & spaces for sale in Port Isabel, TX on our real estate platform. These investment opportunities span a total of 0 square feet of properties for sale, with an estimated market value of $10,500,000.

Sale prices for stores in Port Isabel, TX start at $1,500,000, averaging $5,250,000, and reaching up to $9,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Port Isabel, TX Retail Properties & Spaces for Sale

Highway 100 Commercial Business Opportunity

Turnkey business on Highway 100 in Port Isabel for sale.

Multifaceted Coastal Investment Opportunity

Hospitality, recreation, and lifestyle investment in desirable coastal Texas.