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    Hyannis, MA Retail Properties for Lease

    14 results
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    Main Street Retail and Residence
    $46,200
    2,112 SF

    Main Street Retail and Residence

    547 Main St, Hyannis, MA 02601

    Prime Hyannis location with retail space and on-site residence.

    • Prime Main Street Hyannis location with high year‑round foot traffic and strong summer tourism.
    • Completely rebuilt from the studs out with new walls, ceilings, flooring, plumbing, electrical, HVAC, and finishes.
    • Rare combination of ground‑floor retail space with an on‑site, modern apartment.
    • Open, flexible retail layout with high ceilings and large display windows.
    • Ideal for owner‑operator with living space above the retail business.
    Updated: Jan 7
    View details
    Main Street Retail Opportunity
    $49,020
    2,228 SF

    Main Street Retail Opportunity

    615 Main St, Hyannis, MA 02601

    Prime retail or restaurant space in Hyannis, Massachusetts.

    • Prime location on historic Main Street in Hyannis, Cape Cod, with high car and foot traffic.
    • Versatile 2,200 sq ft space suitable for restaurant, retail, or office use.
    • Located in the Hyannis Main Street Business Improvement District (BID), promoting a clean, safe, and economically developed environment.
    • Walking distance to Nantucket Sound beaches and the Melody Tent.
    • Close proximity to Main Street attractions, Cape Cod Hospital, and ferry service to the islands.
    Updated: Dec 23, 2025
    View details
    Downtown Hyannis Retail Space Available
    $2,325 / Mo
    16,184 SF

    Downtown Hyannis Retail Space Available

    900 SF open retail space on Main Street.

    357 Main St, Hyannis, MA 02601
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    Restaurant Space in Hyannis
    $82,800
    4,259 SF

    Restaurant Space in Hyannis

    Turnkey restaurant space with full commercial kitchen in Hyannis.

    615 Main St, Hyannis, MA 02601
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    Prime Hyannis Retail Space Available
    $2,475 / Mo
    1,188 SF

    Prime Hyannis Retail Space Available

    1,200 sq ft retail space in meticulously maintained complex.

    11 Enterprise Rd, Hyannis, MA 02601
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    Prime Retail Space in Hyannis
    $21 SF/Yr
    3,300 SF

    Prime Retail Space in Hyannis

    Spacious 3,300 SF retail space in downtown Hyannis.

    426 Main St, Hyannis, MA 02601
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    Hyannis Office and Showroom Space
    $23 SF/Yr
    7,792 SF

    Hyannis Office and Showroom Space

    Expansive unit with office, showroom, and gym potential.

    1047 Falmouth Rd, Hyannis, MA 02601
    View details
    Hyannis Restaurant Space For Lease
    $0.02 SF/Yr
    1,860 SF

    Hyannis Restaurant Space For Lease

    High-traffic corner, 1860 sq ft, approved site plan.

    215 Main Street Hyannis, MA 02601, Hyannis, MA 02601
    View details
    Retail Space Available For Lease
    $5,999 / Mo
    4,200 SF

    Retail Space Available For Lease

    Retail space available for lease, totaling 4,200 square feet.

    431 Yarmouth Rd, Hyannis, MA 02601
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    Retail Space in Hyannis
    Contact for pricing
    25,208 SF

    Retail Space in Hyannis

    Retail property for lease in high-traffic Cape Cod location.

    65 Independence Dr, Hyannis, MA
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    Prime Retail Space on Main
    $3,998 / Mo
    2,175 SF

    Prime Retail Space on Main

    Retail space in bustling Hyannis 400 Block on Main.

    388-408 Main St, Hyannis, MA 02668
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    Hyannis Retail Space Available
    $950 / Mo
    1,200 SF

    Hyannis Retail Space Available

    Retail space in busy strip mall off the highway.

    696-700 Yarmouth Rd, Hyannis, MA
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    Class A Business Bay
    $18 SF/Yr
    3,640 SF

    Class A Business Bay

    Immaculate industrial bay with high visibility and modern amenities.

    155 Rosary Ln, Hyannis, MA
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    Hyannis Plaza Retail Space
    $19 SF/Yr
    1,500 SF

    Hyannis Plaza Retail Space

    Retail unit in Hyannis Plaza with open floor plan.

    489 Bearses Way, Hyannis, MA
    View details
    Based on your search, we've compiled 32 Potential Opportunities for your consideration. Besides 14 Active listings in Hyannis, MA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 14 Properties for Sales.

    Explore Retail properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Former Walgreens End Cap Opportunity
    Contact for pricing

    Former Walgreens End Cap Opportunity

    11,800 SF retail space with high traffic counts.

    Barnstable, MA 02648
    View details
    Prime Retail Space on Main
    $19 SF/Yr

    Prime Retail Space on Main

    Spacious retail space in the heart of downtown Hyannis.

    426 Main St, Barnstable, MA 02601
    View details
    Retail Space in South Cape
    Contact for pricing
    1,147 SF

    Retail Space in South Cape

    Retail space available in Mashpee's South Cape Village.

    6 Charles St, Mashpee, MA
    View details
    Retail Space in Mashpee Center
    Contact for pricing
    753 SF

    Retail Space in Mashpee Center

    Retail space available in South Cape Village shopping center.

    12-18 Charles St, Mashpee, MA
    View details

    Explore Similar Spaces for Sale in Hyannis, MA

    Consider Similar Space for Sale. We found 14 Spaces in Nearby Locations matching your search parameters.

    Turn-Key Investment in Hyannis, MA
    $2,000,000
    3,415 SF

    Turn-Key Investment in Hyannis, MA

    Fully renewed mixed-use property with immediate income potential.

    712 Main St, Hyannis, MA 02601
    View details
    Downtown Hyannis Mixed-Use Property
    $1,285,000
    4,032 SF

    Downtown Hyannis Mixed-Use Property

    Turnkey mixed-use property with buildable lot in downtown Hyannis.

    574 Main St, Hyannis, MA 02601
    View details
    Versatile Commercial Property in Hyannis
    $899,000
    4,033 SF

    Versatile Commercial Property in Hyannis

    High-visibility commercial property with flexible space in a vibrant location.

    307 Falmouth Rd, Hyannis, MA 02601
    View details
    Hyannis Retail Property For Sale
    $599,000
    2,822 SF

    Hyannis Retail Property For Sale

    Retail property in Hyannis, MA, with redevelopment potential.

    181 Spring St, Hyannis, MA 02601
    View details
    Downtown Hyannis Two-Unit Building
    Pending
    $1,399,000
    5,348 SF

    Downtown Hyannis Two-Unit Building

    Two-unit building in downtown Hyannis with investment opportunity.

    328 Main St, Hyannis, MA 02601
    View details
    Established Restaurant Business For Sale
    $698,000
    16,239 SF

    Established Restaurant Business For Sale

    Turnkey restaurant and bar with high traffic and loyal clientele.

    950 Iyannough Rd, Hyannis, MA 02601
    View details
    Historic Hyannis Main Street Property
    $574,900
    2,228 SF

    Historic Hyannis Main Street Property

    Prime location suitable for retail, restaurant, or office use.

    615-617 Main St, Hyannis, MA 02668
    View details
    Historic Hyannis Main Street Property
    $574,900

    Historic Hyannis Main Street Property

    2,200 SF space ideal for restaurant or retail.

    615 Main St, Hyannis, MA 02601
    View details
    Established Uniform Supply Business For Sale
    $849,000

    Established Uniform Supply Business For Sale

    Profitable uniform and equipment supplier serving first responders for 35+ years.

    11 Enterprise Rd, Hyannis, MA 02601
    View details
    Hyannis Route 28 Retail Opportunity
    $665,000
    1,300 SF

    Hyannis Route 28 Retail Opportunity

    Restaurant building for sale on busy Route 28 in Hyannis.

    225 Iyannough Rd, Hyannis, MA 02601
    View details

    Hyannis, MA Retail properties Leasing Opportunities Market Analysis

    Explore Retail properties leasing options in Hyannis, MA with 28 listings featured on our commercial real estate exchange. The current inventory includes 1,793,757,240 square feet of properties with an estimated lease value of $156 SF/Yr.

    Estimated lease rates for Retail properties in Hyannis, MA begin at $1.72 SF/Yr, with an average of $17 SF/Yr and extend to $25 SF/Yr.
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    Browse Retail properties for Lease Near Hyannis, MA

    Popular Searches in Hyannis, MA

    Most Searched ZIP Codes in Hyannis, MA

    • 02601
    • 02668

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