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    Poplar Bluff, MO Office Space for Lease

    7 results
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    Downtown Mixed-Use Commercial Space
    $500 / Mo
    1,200 SF

    Downtown Mixed-Use Commercial Space

    106 S Main St, Poplar Bluff, MO 63901

    1,200 sq ft mixed-use space in historic downtown Poplar Bluff.

    • Prime downtown location in historic Poplar Bluff with high traffic and visibility.
    • Flexible 1,200 sq ft mixed‑use space suitable for office, retail, studio, or professional services.
    • Street‑level storefront with excellent overhead signage potential for branding.
    • Readily available on‑street parking and a private parking lot for convenience.
    • Functional layout with 2‑3 private offices, common area, and restroom.
    Updated: Jan 19
    View details
    Versatile Commercial Space on Highway
    $4,000 / Mo
    8,000 SF

    Versatile Commercial Space on Highway

    2323 Cheshire Blvd, Poplar Bluff, MO 63901

    8,000 sq ft building for lease or sale.

    • High‑visibility location on high‑traffic Highway 53
    • Versatile 8,000 sq ft building suitable for various commercial uses
    • Spacious parking lot to accommodate high customer volume
    • Conveniently located near industrial park, shopping centers, and retail businesses
    • Tall ceilings and large display windows
    Updated: Jul 26, 2025
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    Small Office Space For Rent
    $500 / Mo

    Small Office Space For Rent

    Office space for rent, utilities included, common waiting area.

    2051 N Westwood Blvd, Poplar Bluff, MO 63901
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    Prime Retail/Office Space Available
    $1,850 / Mo
    1,862 SF

    Prime Retail/Office Space Available

    Highly visible 1,860 sq ft commercial suite for lease.

    1201 Sterling Dr, Poplar Bluff, MO 63901
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    Remodeled Retail/Office Space Available
    $1,100 / Mo

    Remodeled Retail/Office Space Available

    Remodeled 1,000 sq ft retail/office space in high-traffic location.

    1106 Vine St, Poplar Bluff, MO 63901
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    Office Space with Utilities Included
    $700 / Mo

    Office Space with Utilities Included

    Office space featuring an open area and included utilities.

    2051 N Westwood Blvd, Poplar Bluff, MO 63901
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    Prime Retail/Office Space Available
    $1,850 / Mo
    1,960 SF

    Prime Retail/Office Space Available

    Highly visible 1,960 sq ft commercial suite for lease.

    1213 Sterling Dr, Poplar Bluff, MO 63901
    View details
    Based on your search, we've compiled 17 Potential Opportunities for your consideration. Besides 7 Active listings in Poplar Bluff, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

    Explore Office space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Downtown Sikeston Commercial Property
    $4,500 / Mo
    4,273 SF

    Downtown Sikeston Commercial Property

    Versatile commercial space in downtown Sikeston ready for lease.

    202 S Kingshighway St, Sikeston, MO 63801
    View details
    Sikeston Office Suite For Rent
    $3,625 / Mo
    2,000 SF

    Sikeston Office Suite For Rent

    Recently-built office suite with four offices, bathroom, and kitchenette.

    912 S Main St, Sikeston, MO 63801
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    Prime Office Space in Paragould
    $1,500 / Mo
    900 SF

    Prime Office Space in Paragould

    High-visibility office space in Paragould's bustling commercial district.

    2711 W Kingshighway, Paragould, AR 72450
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    Prime Retail/Office Space Available
    $15 SF/Yr
    2,000 SF

    Prime Retail/Office Space Available

    2000 sq ft space in Paragould's thriving SouthPointe Park.

    11 Southpointe Dr, Paragould, AR 72450
    View details

    Explore Similar Spaces for Sale in Poplar Bluff, MO

    Consider Similar Space for Sale. We found 6 Spaces in Nearby Locations matching your search parameters.

    Poplar Bluff Commercial Building For Sale
    Pending
    $115,000
    3,000 SF

    Poplar Bluff Commercial Building For Sale

    Commercial building on Business Hwy 60, suitable for multiple uses.

    926 W Pine St, Poplar Bluff, MO 63901
    View details
    Versatile Commercial Space in Poplar Bluff
    $299,900
    3,475 SF

    Versatile Commercial Space in Poplar Bluff

    High-traffic location with remodeled space suitable for various business ventures.

    1025 S Westwood Blvd, Poplar Bluff, MO 63901
    View details
    Versatile Commercial Building on Highway
    $419,000
    8,000 SF

    Versatile Commercial Building on Highway

    8,000 sq ft building on high-traffic Highway 53.

    2323 Cheshire Blvd, Poplar Bluff, MO 63901
    View details
    Renovated Commercial Space, Poplar Bluff
    $84,900
    975 SF

    Renovated Commercial Space, Poplar Bluff

    Renovated mixed-use space with high visibility, move-in ready.

    1614 S Broadway St, Poplar Bluff, MO 63901
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    Westwood Blvd Commercial Opportunity
    $599,500
    5,280 SF

    Westwood Blvd Commercial Opportunity

    Prime commercial building on main thoroughfare with income potential.

    2016 N Westwood Blvd, Poplar Bluff, MO 63901
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    Poplar Bluff Commercial Building For Sale
    $950,000
    6,500 SF

    Poplar Bluff Commercial Building For Sale

    6,500 sq ft building on 1.74 acres in Poplar Bluff.

    1026 Highway 67 S, Poplar Bluff, MO 63901
    View details

    Poplar Bluff, MO Office space Leasing Opportunities Market Analysis

    Explore Office space leasing options in Poplar Bluff, MO with 13 listings featured on our commercial real estate exchange. The current inventory includes 567,238,320 square feet of properties with an estimated lease value of $34 SF/Yr.

    Estimated lease rates for Office space in Poplar Bluff, MO begin at $5 SF/Yr, with an average of $8 SF/Yr and extend to $11 SF/Yr.
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    Popular Searches in Poplar Bluff, MO

    Most Searched ZIP Codes in Poplar Bluff, MO

    • 63901

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