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    Port St Lucie, FL Office Space for Lease

    22 results
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    Professional Office Space Available
    $2,287 / Mo
    998 SF

    Professional Office Space Available

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952

    Class A office suite with private offices and open space.

    • Class A Office Space: Enjoy a high‑quality, professional office environment.
    • Convenient Location: Benefit from close proximity to HCA and major highways.
    • Functional Layout: Features 3 private offices and an open workspace.
    • Accessibility: Located on the 2nd floor with elevator access.
    • Ample Parking: Ensures convenient parking for employees and clients.
    Updated: May 18, 2025
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    Medical Office Space For Rent
    $24 SF/Yr
    998 SF

    Medical Office Space For Rent

    1801 SE Hillmoor Dr, Port St Lucie, FL 34952

    Updated medical office space available for rent in Port St. Lucie.

    • Updated with new vinyl plank flooring, paint, and cabinetry.
    • Features 3 exam rooms and 1 lab/kitchen.
    • Includes 2 bathrooms and 2 business offices.
    • Equipped with central heating and air conditioning.
    • Built in 1996 with block and concrete construction.
    Updated: Aug 31, 2025
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    Port St. Lucie Executive Office
    $1,527 / Mo
    998 SF

    Port St. Lucie Executive Office

    Executive office suite in Port St. Lucie medical corridor.

    2100 SE Hillmoor Dr, Port St Lucie, FL 34952
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    St. Lucie West Office Space
    $23 SF/Yr
    2,021 SF

    St. Lucie West Office Space

    Professional and medical office space in St. Lucie West.

    1660 SW St Lucie Blvd W, Port St Lucie, FL
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    Executive Office Suites For Rent
    $500 / Mo
    231 SF

    Executive Office Suites For Rent

    Executive office suites available for lease in Port St. Lucie.

    951 SW Country Clb Dr, Port St Lucie, FL
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    Freestanding Office Space Available
    $25 SF/Yr

    Freestanding Office Space Available

    Office space for rent in high-visibility freestanding building.

    1399 SE Port St Lucie Blvd, Port St Lucie, FL 34952
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    St. Lucie West Professional Office
    $23 SF/Yr
    4,964 SF

    St. Lucie West Professional Office

    Professional office space in a convenient St. Lucie West location.

    537 NW Lk Whitney Pl, Port St Lucie, FL
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    Retail/Office Space on US Highway
    $12 SF/Yr
    19,008 SF

    Retail/Office Space on US Highway

    Retail, office, or medical spaces with high visibility.

    10600-10642 South Federal Hwy, Port St Lucie, FL 34952
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    Tradition Village Square Office Space
    $27 SF/Yr
    28,959 SF

    Tradition Village Square Office Space

    Office space for lease in vibrant Tradition community.

    10801 SW Tradition Sq, Port St Lucie, FL 34987
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    Office/Warehouse Space on Biltmore Street
    $1,600 / Mo

    Office/Warehouse Space on Biltmore Street

    Office and warehouse space available in a prime location.

    1720 SW Biltmore St, Port St Lucie, FL 34953
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    Office Space Available For Rent
    Contact for pricing
    2,750 SF

    Office Space Available For Rent

    Office space available for rent in Port St. Lucie, FL.

    451 SW Bethany Dr, Port St Lucie, FL
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    New Professional Office Space Available
    $25 SF/Yr
    4,130 SF

    New Professional Office Space Available

    New construction office space for lease in Port St. Lucie.

    1380 SW Import Dr, Port St Lucie, FL
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    Professional Office Space Available
    $1,750 / Mo
    450 SF

    Professional Office Space Available

    Office sublet with four private offices, shared amenities, utilities included.

    1800-1900 SE Prt St, Port St Lucie, FL
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    Visible Corner Office Space Available
    $24 SF/Yr
    3,900 SF

    Visible Corner Office Space Available

    Office space with high visibility and convenient access.

    481 Southwest Port St Lucie Blvd, Port St Lucie, FL 34953
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    Port St. Lucie Flex Warehouse
    $20 SF/Yr
    26,880 SF

    Port St. Lucie Flex Warehouse

    Flex warehouse buildings with office space and roll-up doors.

    532-534 Northwest Mercantile Pl, Port St Lucie, FL 34986
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    Professional Office Space Available
    $19 SF/Yr
    6,986 SF

    Professional Office Space Available

    Prime office suites for rent in landmark Port St. Lucie building.

    10570 S Us Highway 1, Port St Lucie, FL 34952
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    New Medical Building End Cap
    $32 SF/Yr
    12,784 SF

    New Medical Building End Cap

    End cap space in a newly constructed medical building.

    1070 Southwest Gatlin Blvd, Port St Lucie, FL 34953
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    Port St. Lucie Office Space
    $13 SF/Yr
    8,200 SF

    Port St. Lucie Office Space

    8,200 SF office space available for lease.

    904 E Prima Vista Blvd, Port St Lucie, FL 34952
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    New Office/Warehouse Space Available
    $20 SF/Yr
    992 SF

    New Office/Warehouse Space Available

    Office/warehouse space with flexible floor plans and high accessibility.

    500-510 NW Peacock Blvd, Port St Lucie, FL
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    Medical Office Space on Lake
    $19 SF/Yr
    1,958 SF

    Medical Office Space on Lake

    Single-story medical office with lake views and recent upgrades.

    573 NW Lk Whitney Pl, Port St Lucie, FL
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    Former Chiropractic/Wellness Space Available
    $23 SF/Yr
    2,979 SF

    Former Chiropractic/Wellness Space Available

    Former chiropractic/wellness space with treatment rooms and private offices.

    7041-7043 S Us Highway 1, Port St Lucie, FL 34952
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    St Lucie West Office Space
    $23 SF/Yr
    2,319 SF

    St Lucie West Office Space

    Medical and professional offices in a convenient location.

    291 NW Peacock Blvd, Port St Lucie, FL
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    Based on your search, we've compiled 28 Potential Opportunities for your consideration. Besides 22 Active listings in Port St Lucie, FL, we suggest exploring alternatives. Similar 6 Properties for Sales.

    Explore Similar Spaces for Sale in Port St Lucie, FL

    Consider Similar Space for Sale. We found 6 Spaces in Nearby Locations matching your search parameters.

    St. Lucie West Commercial Condominium
    $1,300,000

    St. Lucie West Commercial Condominium

    Turn-key commercial condominium in St. Lucie West.

    266 NW Peacock Blvd, Port St Lucie, FL 34986
    View details
    Professional/Medical Office Space For Sale
    $300,000

    Professional/Medical Office Space For Sale

    Office space for sale near HCA Florida St. Lucie Hospital.

    1400 NE Goldtree Dr, Port St Lucie, FL 34952
    View details

    Port St Lucie, FL Office space Leasing Opportunities Market Analysis

    Explore Office space leasing options in Port St Lucie, FL with 28 listings featured on our commercial real estate exchange. The current inventory includes 5,652,065,595 square feet of properties with an estimated lease value of $448 /Mo.

    Estimated lease rates for Office space in Port St Lucie, FL begin at $12 SF/Yr, with an average of $23 SF/Yr and extend to $46 SF/Yr.
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    Browse Office space for Lease Near Port St Lucie, FL

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    Most Searched ZIP Codes in Port St Lucie, FL

    • 34952
    • 34953
    • 34986
    • 34987

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