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Scott County, MO Office Properties & Spaces for Sale

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Remodeled Commercial Building in Sikeston
$775,000
1.67 Acres

Remodeled Commercial Building in Sikeston

210 S Kingshighway St, Sikeston, MO 63801

Remodeled commercial building suitable for single or multiple tenants.

  • Completely remodeled building ideal for single or multiple professional/service‑related tenants.
  • New fire alarm and sprinkler system for enhanced safety.
  • Parking on 3 sides of the building.
  • Large basement accessible by elevator or stairs, suitable for storage or additional offices.
  • Remodel includes new wiring, lights, electrical panels, bathrooms, and floors.
Updated: Feb 26
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Downtown Sikeston Commercial Office Building
$279,000
4,273 SF

Downtown Sikeston Commercial Office Building

202 S Kingshighway St, Sikeston, MO 63801

Commercial property with endless business opportunities in downtown Sikeston.

  • Large 7,638 sq ft building suitable for diverse business opportunities.
  • Prime downtown Sikeston location on a corner lot.
  • Includes 15 parking spaces with handicap accessibility (2 spaces and ramp).
  • Functional layout with reception area, open workspace, private offices, conference room, and break room.
  • Equipped with both stairs and an elevator for basement access.
Updated: Dec 10, 2025
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Sikeston Commercial Building Investment Opportunity
$979,500

Sikeston Commercial Building Investment Opportunity

High-visibility commercial building with income and upside potential.

808 E Wakefield Ave, Sikeston, MO 63801
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Modern Industrial Building with Office
$1,480,000

Modern Industrial Building with Office

10,400 SF industrial building with office and warehouse space.

3046 Nash Rd, Scott City, MO 63780
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Based on your search, we've compiled 224 Potential Opportunities for your consideration. Besides 4 Active listings in Scott County, MO, we suggest exploring several alternatives: similar 217 Off-Market properties to explore as potential leads, plus 3 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land on Highway 61
$144,000
1.01 Acres

Commercial Land on Highway 61

Commercial land on high-traffic route near Sikeston Industrial Park.

103 Grove St, Sikeston, MO 63801
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Commercial Land Ready For Development
$199,000
2.00 Acres

Commercial Land Ready For Development

Two-acre commercial lot available for development in Sikeston, Missouri.

224 S Interstate Dr, Sikeston, MO 63801
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Commercial Land in Sikeston, MO
$195,000
0.72 Acres

Commercial Land in Sikeston, MO

Vacant, level commercial lot available in Sikeston, Missouri.

116 Hospitality Dr, Sikeston, MO 63801
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Explore Off-Market Properties in Scott County, MO

Consider similar Off-Market properties in Scott County, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

34 Winchester

34 Winchester

OFFICE BUILDING • 2,080 SF
Value Estimation by Request
34 Winchester, Benton, MO 63736
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12 Winchester

12 Winchester

OFFICE BUILDING • 900 SF
Value Estimation by Request
12 Winchester, Benton, MO 63736-8257
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112 Winchester

112 Winchester

OFFICE BUILDING • 2,872 SF
Value Estimation by Request
112 Winchester, Benton, MO 63736-9998
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490 Cummins Dr

490 Cummins Dr

OFFICE BUILDING • 48,500 SF
Value Estimation by Request
490 Cummins Dr, Chaffee, MO 63740-8224
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113 Main St

113 Main St

OFFICE BUILDING • 2,150 SF
Value Estimation by Request
113 Main St, Chaffee, MO 63740-1031
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401 Main St

401 Main St

OFFICE BUILDING • 1,134 SF
Value Estimation by Request
401 Main St, Chaffee, MO 63740-1122
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221 Main St

221 Main St

OFFICE BUILDING • 2,698 SF
Value Estimation by Request
221 Main St, Chaffee, MO 63740-1118
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221 Main St

221 Main St

MEDICAL BUILDING • 1,890 SF
Value Estimation by Request
221 Main St, Chaffee, MO 63740-1040
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103 Wright Ave

103 Wright Ave

OFFICE BUILDING • 693 SF
Value Estimation by Request
103 Wright Ave, Chaffee, MO 63740-1126
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2863 Malone Ave

2863 Malone Ave

OFFICE BUILDING • 2,400 SF
Value Estimation by Request
2863 Malone Ave, Sikeston, MO 63801-8616
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106 Plz Dr

106 Plz Dr

OFFICE BUILDING • 2,780 SF
Value Estimation by Request
106 Plz Dr, Sikeston, MO 63801-5137
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2400 Rose Pkwy

2400 Rose Pkwy

OFFICE BUILDING • 188,562 SF
Value Estimation by Request
2400 Rose Pkwy, Sikeston, MO 63801-7192
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217 Tanner St

217 Tanner St

OFFICE BUILDING • 1,796 SF
Value Estimation by Request
217 Tanner St, Sikeston, MO 63801-4268
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Tanner St

Tanner St

OFFICE BUILDING • 2,925 SF
Value Estimation by Request
Tanner St, Sikeston, MO 63801
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713 Tanner St

713 Tanner St

OFFICE BUILDING • 2,782 SF
Value Estimation by Request
713 Tanner St, Sikeston, MO 63801-2160
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314 Crites St

314 Crites St

OFFICE BUILDING • 1,500 SF
Value Estimation by Request
314 Crites St, Scott City, MO 63780-1208
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1704 Main St

1704 Main St

OFFICE BUILDING • 1,224 SF
Value Estimation by Request
1704 Main St, Scott City, MO 63780-1932
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Oakshire

Oakshire

OFFICE BUILDING • 4,238 SF
Value Estimation by Request
Oakshire, Scott City, MO 63780
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100 Outer Rd

100 Outer Rd

OFFICE BUILDING • 2,470 SF
Value Estimation by Request
100 Outer Rd, Scott City, MO 63780-1229
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Sikeston, MO 63801

Sikeston, MO 63801

OFFICE BUILDING • 2,940 SF
Value Estimation by Request
Sikeston, MO 63801
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Scott County, MO Office Properties & Spaces Investment Opportunities Market Analysis

Explore 221 office properties & spaces for sale in Scott County, MO, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 9,741,283 square feet of properties for sale, with an estimated market value of $6,829,000.

Sale prices for office spaces in Scott County, MO start at $279,000, averaging $569,083, and reaching up to $775,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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