Scott County, MO Office properties & Spaces for sale

Remodeled Commercial Building in Sikeston

$775,000

1.67 Acres

Remodeled Commercial Building in Sikeston

210 S Kingshighway St, Sikeston, MO 63801

Remodeled commercial building suitable for single or multiple tenants.

Completely remodeled building ideal for single or multiple professional/service‑related tenants.
New fire alarm and sprinkler system for enhanced safety.
Parking on 3 sides of the building.
Large basement accessible by elevator or stairs, suitable for storage or additional offices.
Remodel includes new wiring, lights, electrical panels, bathrooms, and floors.

Updated: Feb 26

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Downtown Sikeston Commercial Office Building

$279,000

4,273 SF

Downtown Sikeston Commercial Office Building

202 S Kingshighway St, Sikeston, MO 63801

Commercial property with endless business opportunities in downtown Sikeston.

Large 7,638 sq ft building suitable for diverse business opportunities.
Prime downtown Sikeston location on a corner lot.
Includes 15 parking spaces with handicap accessibility (2 spaces and ramp).
Functional layout with reception area, open workspace, private offices, conference room, and break room.
Equipped with both stairs and an elevator for basement access.

Updated: Dec 10, 2025

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$979,500

Sikeston Commercial Building Investment Opportunity

High-visibility commercial building with income and upside potential.

808 E Wakefield Ave, Sikeston, MO 63801

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$1,480,000

Modern Industrial Building with Office

10,400 SF industrial building with office and warehouse space.

3046 Nash Rd, Scott City, MO 63780

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

$144,000

1.01 Acres

Commercial Land on Highway 61

Commercial land on high-traffic route near Sikeston Industrial Park.

103 Grove St, Sikeston, MO 63801

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$199,000

2.00 Acres

Commercial Land Ready For Development

Two-acre commercial lot available for development in Sikeston, Missouri.

224 S Interstate Dr, Sikeston, MO 63801

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$195,000

0.72 Acres

Commercial Land in Sikeston, MO

Vacant, level commercial lot available in Sikeston, Missouri.

116 Hospitality Dr, Sikeston, MO 63801

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Explore Off-Market Properties in Scott County, MO

Consider similar Off-Market properties in Scott County, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

34 Winchester

OFFICE BUILDING • 2,080 SF

Value Estimation by Request

34 Winchester, Benton, MO 63736

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12 Winchester

OFFICE BUILDING • 900 SF

Value Estimation by Request

12 Winchester, Benton, MO 63736-8257

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112 Winchester

OFFICE BUILDING • 2,872 SF

Value Estimation by Request

112 Winchester, Benton, MO 63736-9998

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490 Cummins Dr

OFFICE BUILDING • 48,500 SF

Value Estimation by Request

490 Cummins Dr, Chaffee, MO 63740-8224

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113 Main St

OFFICE BUILDING • 2,150 SF

Value Estimation by Request

113 Main St, Chaffee, MO 63740-1031

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401 Main St

OFFICE BUILDING • 1,134 SF

Value Estimation by Request

401 Main St, Chaffee, MO 63740-1122

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221 Main St

OFFICE BUILDING • 2,698 SF

Value Estimation by Request

221 Main St, Chaffee, MO 63740-1118

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221 Main St

MEDICAL BUILDING • 1,890 SF

Value Estimation by Request

221 Main St, Chaffee, MO 63740-1040

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103 Wright Ave

OFFICE BUILDING • 693 SF

Value Estimation by Request

103 Wright Ave, Chaffee, MO 63740-1126

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2863 Malone Ave

OFFICE BUILDING • 2,400 SF

Value Estimation by Request

2863 Malone Ave, Sikeston, MO 63801-8616

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106 Plz Dr

OFFICE BUILDING • 2,780 SF

Value Estimation by Request

106 Plz Dr, Sikeston, MO 63801-5137

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2400 Rose Pkwy

OFFICE BUILDING • 188,562 SF

Value Estimation by Request

2400 Rose Pkwy, Sikeston, MO 63801-7192

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217 Tanner St

OFFICE BUILDING • 1,796 SF

Value Estimation by Request

217 Tanner St, Sikeston, MO 63801-4268

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Tanner St

OFFICE BUILDING • 2,925 SF

Value Estimation by Request

Tanner St, Sikeston, MO 63801

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713 Tanner St

OFFICE BUILDING • 2,782 SF

Value Estimation by Request

713 Tanner St, Sikeston, MO 63801-2160

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314 Crites St

OFFICE BUILDING • 1,500 SF

Value Estimation by Request

314 Crites St, Scott City, MO 63780-1208

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1704 Main St

OFFICE BUILDING • 1,224 SF

Value Estimation by Request

1704 Main St, Scott City, MO 63780-1932

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Oakshire

OFFICE BUILDING • 4,238 SF

Value Estimation by Request

Oakshire, Scott City, MO 63780

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100 Outer Rd

OFFICE BUILDING • 2,470 SF

Value Estimation by Request

100 Outer Rd, Scott City, MO 63780-1229

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Sikeston, MO 63801

OFFICE BUILDING • 2,940 SF

Value Estimation by Request

Sikeston, MO 63801

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Scott County, MO Office Properties & Spaces Investment Opportunities Market Analysis

Explore 221 office properties & spaces for sale in Scott County, MO, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 9,741,283 square feet of properties for sale, with an estimated market value of $6,829,000.

Sale prices for office spaces in Scott County, MO start at $279,000, averaging $569,083, and reaching up to $775,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Scott County, MO Office Properties & Spaces for Sale

Remodeled Commercial Building in Sikeston

Remodeled commercial building suitable for single or multiple tenants.

Downtown Sikeston Commercial Office Building

Commercial property with endless business opportunities in downtown Sikeston.