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    Columbia County, FL Office Properties & Spaces for Sale

    9 results
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    Remodeled Home Office Building
    $259,900
    2,442 SF

    Remodeled Home Office Building

    340 SE Country Club Rd, Lake City, FL 32025

    Remodeled office building with live-work potential in Lake City.

    • Newly remodeled home office building, perfect for living and running a business or leasing for income.
    • Enjoy the benefits of a new A/C, windows, paint, floors, electric throughout, and service panel.
    • Features 8 rooms and 2 bathrooms.
    • Durable metal roof.
    • Galley kitchen and convenient in‑unit washer and dryer.
    Updated: Jan 3
    View details
    Lake City Professional Office
    $295,000
    1,208 SF

    Lake City Professional Office

    1166 SW Main Blvd, Lake City, FL 32025

    Commercial office building with reception, exam rooms, and bathroom.

    • Great location on Main Blvd.
    • Previously used as a dental office, suitable for similar practices.
    • Includes 4 exam rooms/offices.
    • Reception/lobby area with front desk and window.
    • Brick construction.
    Updated: Dec 22, 2025
    View details
    Lake City Office Suite
    $770,000
    4,315 SF

    Lake City Office Suite

    4,315 SF office suite in Perimeter Park, Lake City.

    440 SW Perimeter Gln, Lake City, FL 32025
    View details
    Lake City Executive Park Complex
    $1,200,000
    16,050 SF

    Lake City Executive Park Complex

    Fully leased office complex near I-75, a steady income generator.

    260 S Marion Ave, Lake City, FL 32025
    View details
    Main Boulevard Office Building
    $419,000
    1,823 SF

    Main Boulevard Office Building

    Class B office building with expansion and investment potential.

    229 SW Main Blvd, Lake City, FL 32025
    View details
    Commercial Building in Downtown Lake
    $249,000

    Commercial Building in Downtown Lake

    Commercial building in Lake City suitable for store or office.

    508 N Marion Ave, Lake City, FL 32055
    View details
    Lake City Office Space Available
    $199,654
    1,529 SF

    Lake City Office Space Available

    Professional office space with multiple offices, conference room, and kitchen.

    654 Baya Dr, Lake City, FL 32025
    View details
    Lake City Mixed-Use Investment Opportunity
    $650,000
    1,770 SF

    Lake City Mixed-Use Investment Opportunity

    Gas station, hotel, restaurant; prime location.

    3827 Us-441, Lake City, FL 32055
    View details
    Lake City Mixed-Use Commercial Building
    $595,000
    3,168 SF

    Lake City Mixed-Use Commercial Building

    Highway 41 Frontage, 3168 SF, $595,000

    2832 Main Blvd, Lake City, FL 32025
    View details
    Based on your search, we've compiled 383 Potential Opportunities for your consideration. Besides 9 Active listings in Columbia County, FL, we suggest exploring several alternatives: similar 370 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Lake City Commercial Land
    $49,995
    6.52 Acres

    Lake City Commercial Land

    6.52 acre commercial land for sale in Lake City.

    Bascom Norris Dr, Lake City, FL 32055
    View details
    Commercial Lot Near I-75
    $250,000
    1.02 Acres

    Commercial Lot Near I-75

    Commercial land in a rapidly developing area near major routes.

    637 SW Commerce Dr, Lake City, FL 32025
    View details
    Lake City Commercial Lot Available
    $400,000
    2.04 Acres

    Lake City Commercial Lot Available

    Prime commercial lot in a rapidly developing area.

    SW Commerce Dr, Lake City, FL 32025
    View details
    Commercial Lot Near I-75
    $500,000
    3.06 Acres

    Commercial Lot Near I-75

    Commercial land in a rapidly developing area near major routes.

    SW Commerce Dr, Lake City, FL 32025
    View details

    Explore Off-Market Properties in Columbia County, FL

    Consider similar Off-Market properties in Columbia County, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    3827 Us-441

    3827 Us-441

    Restaurants • 1,770 SF
    Value Estimation by Request
    3827 Us-441, Lake City, FL 32055
    View details
    284 Baya Dr

    284 Baya Dr

    Office space • 2,916 SF
    Value Estimation by Request
    284 Baya Dr, Lake City, FL 32025
    View details
    879 Main Blvd

    879 Main Blvd

    Individual retail properties
    Value Estimation by Request
    879 Main Blvd, Lake City, FL 32025
    View details
    579 Baya Dr

    579 Baya Dr

    Office Properties & Spaces
    Value Estimation by Request
    579 Baya Dr, Lake City, FL 32025
    View details
    Baya Dr

    Baya Dr

    Office space • 1,152 SF
    Value Estimation by Request
    0 Baya Dr, Lake City, FL 32025
    View details
    2941 Us Highway 90

    2941 Us Highway 90

    Medical offices
    Value Estimation by Request
    2941 Us Highway 90, Lake City, FL 32025
    View details
    204 Marion Ave

    204 Marion Ave

    Restaurants • 83,595 SF
    Value Estimation by Request
    204 Marion Ave, Lake City, FL 32055
    View details
    475 County Rd 245

    475 County Rd 245

    OFFICE (GENERAL) • 2,835 SF
    Value Estimation
    $445,000
    475 County Rd 245, Lake City, FL 32025-1998
    View details
    4367 American Ln

    4367 American Ln

    MEDICAL BUILDING • 5,484 SF
    Value Estimation
    $385,000
    4367 American Ln, Lake City, FL 32055-4828
    View details
    3526 Us Hwy 90

    3526 Us Hwy 90

    OFFICE (GENERAL) • 4,524 SF
    Value Estimation
    $360,000
    3526 Us Hwy 90, Lake City, FL 32055-1418
    View details
    4447 American Ln

    4447 American Ln

    MEDICAL BUILDING • 1,741 SF
    Value Estimation
    $295,000
    4447 American Ln, Lake City, FL 32055-6891
    View details
    4355 American Ln

    4355 American Ln

    MEDICAL BUILDING • 2,607 SF
    Value Estimation
    $275,000
    4355 American Ln, Lake City, FL 32055-4828
    View details
    690 Duval St

    690 Duval St

    OFFICE (GENERAL) • 4,032 SF
    Value Estimation
    $365,000
    690 Duval St, Lake City, FL 32055-3485
    View details
    Lake

    Lake

    PROFESSIONAL BUILDING • 0.07 Acres
    Value Estimation by Request
    Lake, City, FL 32055
    View details
    730 Nassau St

    730 Nassau St

    OFFICE BUILDING • 2,760 SF
    Value Estimation
    $410,000
    730 Nassau St, Lake City, FL 32025-4582
    View details

    Columbia County, FL Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 378 office properties & spaces for sale in Columbia County, FL, showcased through 9 active listings on our real estate platform. These investment opportunities span a total of 21,090,618 square feet of properties for sale, with an estimated market value of $122,163,554.

    Prices for office spaces in Columbia County, FL start at $50,000, averaging $425,656, and reaching up to $9,290,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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    Office Properties & Spaces by market

    Browse Office Properties & Spaces for Sale Near Columbia, FL

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