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    Lee County, MS Office Spaces for Lease

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    Jackson, MS Ridgeland, MS Gulfport, MS Hattiesburg, MS Olive Branch, MS Flowood, MS Tupelo, MS Southaven, MS
    15 properties
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    Office Space in Tupelo
    Updated: Nov 24, 2025
    Office Space in Tupelo

    609 Brunson Dr, Tupelo, MS

    $18 SF/Yr
    3,785 sqft
    Office space available for lease
    Located in Tupelo, Mississippi
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    Office Space For Rent
    Updated: Nov 24, 2025
    Office Space For Rent

    499 S Gloster St, Tupelo, MS

    $18 SF/Yr
    2,082 sqft
    Office space available for lease
    Located in Tupelo, Mississippi
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    Office Space in Tupelo
    Office Space in Tupelo

    144 S Thomas St, Tupelo, MS

    $16 SF/Yr
    1,140 sqft

    Office space available for lease in Tupelo, Mississippi.

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    Office Space in Tupelo
    Office Space in Tupelo

    495 S Gloster St, Tupelo, MS

    $20 SF/Yr
    2,323 sqft

    Office space available for lease in Tupelo, Mississippi.

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    Industrial Warehouse Facility For Lease
    Industrial Warehouse Facility For Lease

    177 Bryan Blvd, Shannon, MS 38868

    Contact for pricing
    120,000 sqft

    120,000+/- sq ft industrial warehouse in Northeast Mississippi.

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    Updated Historical Flex Space
    Updated Historical Flex Space

    654 W Main St, Tupelo, MS 38804

    $14 SF/Yr

    Storefront retail or office space near Crosstown in Tupelo.

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    Two-Story Downtown Office Space
    Two-Story Downtown Office Space

    84 Clark Boulevard, Tupelo, MS 38804

    Contact for pricing

    Flexible two-story office layout with multiple private offices and dedicated training and conference rooms.

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    Downtown Tupelo Office Space Available
    Downtown Tupelo Office Space Available

    111 S Spring St, Tupelo, MS 38804

    $16 SF/Yr
    5,525 sqft

    Office space for lease in historic downtown Tupelo.

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    Tupelo Office Building Available
    Tupelo Office Building Available

    809 Varsity Dr, Tupelo, MS

    Contact for pricing
    21,499 sqft

    Office building with 21,499 square feet available for lease/sale.

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    Spacious Warehouse with Office Space
    Spacious Warehouse with Office Space

    4799 S Eason Blvd, Tupelo, MS 38801

    Contact for pricing
    320,000 sqft

    320,000 SF warehouse with 14,000 SF office on 41.6 acres.

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    Upscale Office Space Available
    Upscale Office Space Available

    431 W Main St, Tupelo, MS 38804

    $16 SF/Yr

    Professional office building in the heart of the CBD.

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    Professional Office Complex Space Available
    Professional Office Complex Space Available

    144 S Thomas St, Tupelo, MS 38801

    $16 SF/Yr
    18,000 sqft

    Modernized office spaces available in a multi-tenant professional complex.

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    Retail Space in Tupelo Center
    Retail Space in Tupelo Center

    3875 N Gloster St, Tupelo, MS 38804

    $30 SF/Yr
    66,000 sqft

    Retail spaces available in a busy shopping center.

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    Mixed-Use Complex in Saltillo
    Mixed-Use Complex in Saltillo

    119 City Market Dr, Saltillo, MS 38866

    $20 SF/Yr
    36,000 sqft

    36,000 SF mixed-use complex with medical and commercial spaces.

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    Class A Medical Complex Space
    Class A Medical Complex Space

    961 S Gloster St, Tupelo, MS 38801

    $22 SF/Yr

    Adaptable medical space near North MS Medical Center.

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    Based on your search, we've compiled 27 Potential Opportunities for your consideration. Besides 15 Active listings in Lee County, MS, we suggest exploring alternatives. Similar 8 Properties for Sales.

    Similar Spaces for Sale in Lee County, MS

    Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

    Commercial Office Building
    Commercial Office Building

    704 N Gloster St, Tupelo, MS 38804

    $819,950
    7,000 sqft

    Commercial office building listed for sale in Tupelo, MS with Commercial zoning.

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    Office Building in Mixed-Use Zoning
    Office Building in Mixed-Use Zoning

    806 Garfield St, Tupelo, MS 38801

    $494,900
    3,305 sqft 0.27 AC lot

    Small office building for sale in Mixed Use zoning with a 3,305-square-foot footprint.

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    Mixed-Use Commercial Building
    Mixed-Use Commercial Building

    1090 County Road 833, Guntown, MS 38849

    $165,000
    2,400 sqft 2.00 AC lot

    Versatile building on a 2-acre lot with office space, kitchen area, and a large multipurpose main room plus three half baths.

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    Mixed-Use Zoned Office Building
    Mixed-Use Zoned Office Building

    743 Senter St, Tupelo, MS 38801

    $240,000
    5,000 sqft 1.28 AC lot

    For sale office building on a 1.28-acre lot in Tupelo, MS, totaling 5,000 square feet.

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    Office Building with Mixed Use Zoning
    Office Building with Mixed Use Zoning

    Tupelo, MS 38801

    $475,000
    3,225 sqft 0.34 AC lot

    Well-sized office property offered for sale, situated within mixed use zoning for flexible planning.

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    Tupelo Office Building For Sale
    Tupelo Office Building For Sale

    1015 South Green Street, Tupelo, MS 38804

    $3,500,000
    48,056 sqft

    48,056 square foot office building in Tupelo, Mississippi.

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    Office Space in Tupelo, MS
    Office Space in Tupelo, MS

    1203 Nelle St, Tupelo, MS

    $225,000
    2,400 sqft 0.11 AC lot

    Office property with 2400 square feet available for sale.

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    Office Suite with Two Bathrooms
    Office Suite with Two Bathrooms

    1090 S Veterans Memorial Blvd, Tupelo, MS 38804

    Contact for pricing

    Right side office suite offers two large rooms, two bathrooms, and a fully supplied kitchen.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    1.7 acre corner lot zoned for commercial, medical, residential.

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    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft

    2.43 acres for office development with build-to-suit opportunity.

    View details
    Highway 14 Commercial Investment Property
    Highway 14 Commercial Investment Property

    2400 Highway 14, Millbrook, AL 36054

    $3,980,250/Mo
    770,576 sqft

    Investment property with highway frontage in growing Millbrook corridor.

    View details
    Commercial Land in Powder Springs
    Commercial Land in Powder Springs

    2125 Brownsville Road, Powder Springs, GA 30127

    $3,000/Mo
    2,690 sqft

    4.5 acres of commercial land for ground lease.

    View details

    Lee County, MS Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Lee County, MS with 15 listings featured on our commercial real estate exchange. The current inventory includes 134,855 square feet of properties with an estimated lease value of $154 SF/Yr.

    Estimated lease rates for Office Spaces in Lee County, MS begin at $16 SF/Yr, with an average of $19.25 SF/Yr and extend to $30 SF/Yr.
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