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    Tupelo, MS
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    Tupelo, MS Office Spaces for Lease

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    Shannon, MS Saltillo, MS Hattiesburg, MS
    14 results
    Office Space in Tupelo
    $18 SF/Yr
    3,785 SF
    Office Space in Tupelo

    609 Brunson Dr, Tupelo, MS

    Office space available for lease in Tupelo, Mississippi.
    • Office space available for lease
    • Located in Tupelo, Mississippi
    Updated: Nov 24, 2025
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    Office Space For Rent
    $18 SF/Yr
    2,082 SF
    Office Space For Rent

    499 S Gloster St, Tupelo, MS

    Office space available for lease in Tupelo, Mississippi.
    • Office space available for lease
    • Located in Tupelo, Mississippi
    Updated: Nov 24, 2025
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    Office Space in Tupelo
    $20 SF/Yr
    2,323 SF
    Office Space in Tupelo

    Office space available for lease in Tupelo, Mississippi.

    495 S Gloster St, Tupelo, MS

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    Office Space in Tupelo
    $16 SF/Yr
    1,140 SF
    Office Space in Tupelo

    Office space available for lease in Tupelo, Mississippi.

    144 S Thomas St, Tupelo, MS

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    Office Space Available For Rent
    $18 SF/Yr
    2,100 SF
    Office Space Available For Rent

    Office space available for rent, totaling 2,100 square feet.

    114 S Broadway St, Tupelo, MS

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    Updated Historical Flex Space
    Contact for pricing
    Updated Historical Flex Space

    Storefront retail or office space near Crosstown in Tupelo.

    654 W Main St, Tupelo, MS 38804

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    Adaptable Retail Space For Rent
    Contact for pricing
    1,416 SF
    Adaptable Retail Space For Rent

    Adaptable space near Walmart, high traffic, ample parking.

    311 S Gloster St, Tupelo, MS 38801

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    Tupelo Office Building Available
    Contact for pricing
    21,499 SF
    Tupelo Office Building Available

    Office building with 21,499 square feet available for lease/sale.

    809 Varsity Dr, Tupelo, MS

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    Downtown Tupelo Office Space Available
    $16 SF/Yr
    5,525 SF
    Downtown Tupelo Office Space Available

    Office space for lease in historic downtown Tupelo.

    111 S Spring St, Tupelo, MS 38804

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    Redeveloped Retail and Office Space
    $115 SF/Yr
    4,000 SF
    Redeveloped Retail and Office Space

    Retail and office spaces available for lease after redevelopment.

    4970 Raymond Ave, Tupelo, MS 38801

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    New Retail and Office Center
    $17 SF/Yr
    23,000 SF
    New Retail and Office Center

    New 23,000+ sq ft shopping center in Tupelo, MS.

    1507 W Main St, Tupelo, MS 38801

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    Upscale Office Space Available
    $16 SF/Yr
    Upscale Office Space Available

    Professional office building in the heart of the CBD.

    431 W Main St, Tupelo, MS 38804

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    Professional Office Complex Space Available
    $16 SF/Yr
    18,000 SF
    Professional Office Complex Space Available

    Modernized office spaces available in a multi-tenant professional complex.

    144 S Thomas St, Tupelo, MS 38801

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    Retail Space in Tupelo Center
    $30 SF/Yr
    66,000 SF
    Retail Space in Tupelo Center

    Retail spaces available in a busy shopping center.

    3875 N Gloster St, Tupelo, MS 38804

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    Based on your search, we've compiled 33 Potential Opportunities for your consideration. Besides 14 Active listings in Tupelo, MS, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 11 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office and Warehouse Flex Space
    Contact for pricing
    5,080 SF
    Office and Warehouse Flex Space

    Office and warehouse space with highway frontage and accessibility.

    2891 South Frontage Road, Columbus, MS 39701

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    Oxford Commercial Flex-Use Space
    $7,400/Mo
    3,700 SF
    Oxford Commercial Flex-Use Space

    Two-story commercial space in prime Oxford location.

    2014 University Ave, Oxford, MS 38655

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    Retail, Office
    Contact for pricing
    6,000 SF
    Retail, Office

    Retail space · 6,000 SF

    1600 Grand Oaks Blvd, Oxford, MS 38655

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    Retail Space in Columbus, MS
    $9 SF/Yr
    Retail Space in Columbus, MS

    Retail and office spaces available in a commercial district.

    2310-2318 US-45, Columbus, MS 39701

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    Similar Spaces for Sale in Tupelo, MS

    Consider Similar Space for Sale. We found 11 Spaces matching your search parameters.

    Tupelo Commercial Property on Main
    $379,900
    2,580 SF
    Tupelo Commercial Property on Main

    Commercial property on West Main Street in Tupelo, Mississippi.

    641 West Main Street, Tupelo, MS 38804

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    Tupelo Commercial Property For Sale
    $350,000
    2,022 SF
    Tupelo Commercial Property For Sale

    Former restaurant space near Cadence Arena, ideal for various businesses.

    203 Commerce St., Tupelo, MS 38804

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    Tupelo Mixed-Use Investment Property
    $180,000
    4,200 SF
    Tupelo Mixed-Use Investment Property

    Mixed-use property featuring two leased warehouses with office space.

    1225 Nelle, Tupelo, MS 38801

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    Commercial Property in High-Traffic Area
    $999,590
    12,070 SF
    Commercial Property in High-Traffic Area

    Well-maintained commercial property in Tupelo with high traffic counts.

    1993 McCullough, Tupelo, MS 38801

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    High-Visibility Medical Office Building
    $475,000
    3,225 SF
    High-Visibility Medical Office Building

    Well-appointed medical office near North Mississippi Medical Center.

    Tupelo, MS 38801

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    Tupelo Commercial Property For Sale
    $795,000
    5,456 SF
    Tupelo Commercial Property For Sale

    Versatile commercial building near NMMC Hospital, suitable for medical or office.

    1464 Medical Park Cr., Tupelo, MS 38801

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    Tupelo Commercial Property with Acreage
    $1,198,950
    6,500 SF
    Tupelo Commercial Property with Acreage

    6,500 sq ft building on 6 acres near intersection.

    4432 N Gloster St., Tupelo, MS 38804

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    Commercial Corner Lot in Tupelo
    Contact for pricing
    0.95 Acres
    Commercial Corner Lot in Tupelo

    Nearly one-acre commercial corner lot suitable for various developments.

    Senter St., Tupelo, MS 38801

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    Tupelo Office Building For Sale
    $3,500,000
    48,056 SF
    Tupelo Office Building For Sale

    48,056 square foot office building in Tupelo, Mississippi.

    1015 South Green Street, Tupelo, MS 38804

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    Office Space in Tupelo, MS
    $225,000
    2,400 SF
    Office Space in Tupelo, MS

    Office property with 2400 square feet available for sale.

    1203 Nelle St, Tupelo, MS

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Corner Lot on Highway 72
    $5,000/Mo
    1,875 SF
    Corner Lot on Highway 72

    1.7 acre corner lot zoned for commercial, medical, residential.

    30472 Highway 72, Madison, AL 35756

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    Highway 14 Commercial Investment Property
    $3,980,250 SF/Yr
    770,576 SF
    Highway 14 Commercial Investment Property

    Investment property with highway frontage in growing Millbrook corridor.

    2400 Highway 14, Millbrook, AL 36054

    View details
    Commercial Land in Powder Springs
    $3,000/Mo
    2,690 SF
    Commercial Land in Powder Springs

    4.5 acres of commercial land for ground lease.

    2125 Brownsville Road, Powder Springs, GA 30127

    View details
    Commercial Land in Abita Springs
    $3,500/Mo
    Commercial Land in Abita Springs

    Commercial property in Abita Springs' Historical District available for rent.

    72405 59 Highway, Abita Springs, LA 70420

    View details

    Tupelo, MS Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Tupelo, MS with 14 listings featured on our commercial real estate exchange. The current inventory includes 127,955 square feet of properties with an estimated lease value of $284 SF/Yr.

    Estimated lease rates for Office Spaces in Tupelo, MS begin at $16 SF/Yr, with an average of $28 SF/Yr and extend to $115 SF/Yr.
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