Brentwood, MO Office Spaces for Rent & Lease

Updated: Nov 22, 2025

Class A Office Space Available

1405 South Hanley Road, Brentwood, MO 63144

$28.50 SF/Yr

30,000 sqft

Premier Class A office space in a highly desirable St. Louis market.
Dedicated MetroLink stop on site for convenient access.
Ample free parking (5/1000) in a multi‑story garage with covered walkways.
Unmatched visibility and unbeatable access.
Executive conferencing and auditorium facilities available.

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Updated: Nov 22, 2025

Brentwood Office Space For Lease

8374 Eager Road, Brentwood, MO 63144

$25 SF/Yr

70,000 sqft

+70,000 SF available on 2nd floor
Dedicated MetroLink stop on site for easy commuting
Free 5/1000 Parking in multistory parking garage
Located in a premier mixed‑use development
Open, efficient floor plan

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Manchester Road Retail/Office/Medical Space

8500-8518 Manchester Rd, Brentwood, MO

Contact for pricing

2,600 sqft 1.10 AC lot

Prime commercial space suitable for retail, office, or medical use.

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Brentwood Office Space For Lease

8328-8374 Eager Rd, Brentwood, MO

Contact for pricing

70,000 sqft 12.28 AC lot

70,000 SF office space with dedicated MetroLink stop.

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Based on your search, we've compiled 8 Potential Opportunities for your consideration. Besides 4 Active listings in Brentwood, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Space with Private Entrance

2117-2121 S Brentwood Blvd, Saint Louis, MO 63144

$20 SF/Yr

3,418 sqft

Two-level office suite offers private entrance, multiple offices, and built-in kitchen and breakroom areas.

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Flexible Office Units

3544 Oxford, Maplewood, MO 63143

$1,500/Mo

Office space includes private rooms, open work areas, kitchenette access, and shared outdoor amenities.

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Flex Building with Office Space

2015 S Big Bend Boulevard, Maplewood, MO 63117

$3,500/Mo

0.13 AC lot

Commercial facility with multiple entrances, offices, kitchen, conference space, and front and rear parking areas.

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Class A Office Space Available

Saint Louis, MO 63144

$28.50 SF/Yr

104,000 sqft

Premier St. Louis office space with unmatched amenities and access.

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Brentwood, MO Office Spaces Lease Rates & Market Statistics

Explore 4 Office Spaces for lease in Brentwood, MO on Realmo, a commercial real estate exchange covering the Brentwood area. The current inventory totals 172,600 square feet of properties.

Office Spaces lease rates in Brentwood range from $25 SF/Yr at the entry level to $28.50 SF/Yr at the top of the market, averaging $26.75 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $26.75 SF/Yr is 5% above the Missouri state average of $25.49 SF/Yr.

Brentwood accounts for 1% of the 383 office spaces currently available across St. Louis County, where nearby markets include Saint Louis and Chesterfield.