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Opelousas, LA Office Spaces for Lease

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Church Point, LA Carencro, LA Arnaudville, LA Ville Platte, LA Lafayette, LA Scott, LA Breaux Bridge, LA Eunice, LA
11 properties
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Office Suite with Two Private Offices
Updated: Mar 11
Office Suite with Two Private Offices

1004 Creswell Lane, Opelousas, LA 70570

Contact for pricing
1,665 sqft 0.15 AC lot
1,665 SF office suite with an open floor area and two private offices
Common break/coffee area and restroom included
0.15‑acre lot with parking in front and rear and a parking lot
Located in a high‑traffic area near I‑49
Natural gas central heating and central air conditioning
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Physician-Built Office Suite
Updated: Feb 25, 2025
Physician-Built Office Suite

816 Creswell Lane, Opelousas, LA 70570

Contact for pricing
4,326 sqft
High traffic and visibility location
Large office space (over 4300 sq ft)
Flexible space adaptable to various business types
Existing layout includes reception area, file room, and numerous offices
Off‑street parking with assigned spots
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Main Street Office Building
Main Street Office Building

223 S Main Street, Opelousas, LA 70570

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2,100 sqft

Office building with multiple private offices, conference room, kitchen break room, and updated bath facilities.

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Warehouse with Office and Yard
Warehouse with Office and Yard

1427 West Linwood Drive, Opelousas, LA 70570

$5,250/Mo
19,358 sqft 0.50 AC lot

Flex-style setup with a stabilized yard, office space, and warehouse access via grade-level and half-dock doors.

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Professional Office Units
Professional Office Units

2414 Jake Dr, Opelousas, LA 70570

$2,200/Mo
2,080 sqft

Office space in a C-1 plaza with parking accommodations, available beginning April 1, 2026.

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Professional Office Unit
Professional Office Unit

2410 Jake Drive, Opelousas, LA 70570

$1,600/Mo
1,520 sqft

Commercially zoned space suited to insurance, accounting, finance, or health care operations.

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Medical Office Space With Easy Access
Medical Office Space With Easy Access

528 E Vine St, Opelousas, LA 70570

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7,010 sqft

Former medical office along Hwy 190 with easy access and approximately 7,000 SF suited for professional office use.

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Medical Office and Surgical Center
Medical Office and Surgical Center

1418 Heather Dr, Opelousas, LA 70570

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6,424 sqft

Modern medical office and surgical center with move-in-ready interiors, exam and procedure rooms, and ample on-site parking.

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Medical Office Built-Out Suite
Medical Office Built-Out Suite

816 Creswell Ln, Opelousas, LA 70570

$4,697/Mo
4,326 sqft

Large office suite with a reception area, file room, and numerous offices in a physician-practice buildout.

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Corner Retail Space Near Cinema
Corner Retail Space Near Cinema

1200 Heather Dr, Opelousas, LA 70570

$12 SF/Yr
4,500 sqft

C-2-zoned commercial space at Heather Drive and Jake Drive, positioned near established retail and entertainment destinations.

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Medical Office Suite Off I-49
Medical Office Suite Off I-49

5620 I 49 S Service Rd, Opelousas, LA 70570

$3,000/Mo
3,014 sqft

Office suite available right off I-49 in Opelousas, offering a convenient location for medical users.

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Based on your search, we've compiled 39 Potential Opportunities for your consideration. Besides 11 Active listings in Opelousas, LA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 24 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Two-Floor Flex Space with Storage
Two-Floor Flex Space with Storage

310 E Gloria Switch Rd, Lafayette, LA 70507

$1,700/Mo
3,240 sqft

Flexible facility combines office, temperature-controlled storage, and warehouse space with roll-up access.

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Retail or Office Suite in Center
Retail or Office Suite in Center

105-107 Hector Connoly Rd, Carencro, LA 70520

$2,300/Mo
1,400 sqft

Lease a flexible retail or office space within a multi-tenant center featuring established local co-tenancy.

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Retail Space in Commercial Center
Retail Space in Commercial Center

107 Hector Connoly Rd, Carencro, LA 70520

$2,300/Mo
1,400 sqft

Flexible commercial suite suitable for retail, service, or professional office use with access near I-49.

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Flex Facility with Shop Space
Flex Facility with Shop Space

113 E Gloria Switch Road, Lafayette, LA 70507

$9.50 SF/Yr
15,772 sqft

Flexible commercial facility combines showroom-style office space with warehouse and service areas.

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Similar Spaces for Sale in Opelousas, LA

Consider Similar Space for Sale. We found 24 Spaces matching your search parameters.

Downtown Office Building
Downtown Office Building

103 E Bellevue St, Opelousas, LA 70570

$950,000
13,060 sqft

DMU-zoned commercial property with space suited to banking, mortgage, or professional office operations.

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Two-Story Office Building
Two-Story Office Building

505 S Court Street, Opelousas, LA 70570

$250,000
3,642 sqft 0.24 AC lot

Commercial zoning and a flexible interior support professional office use.

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Standalone Office Building
Standalone Office Building

523 S Main St, Opelousas, LA 70570

$110,000
1,500 sqft

Vacant professional workspace with potential for medical, legal, or creative office use.

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Two-Story Office Building
Two-Story Office Building

505 S Court St, Opelousas, LA 70570

$250,000
3,642 sqft

Functional layout includes private offices, conference space, and support areas.

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Standalone Office Building
Standalone Office Building

523 S Main Street, Opelousas, LA 70570

$110,000
1,500 sqft 0.09 AC lot

Vacant commercial property with central HVAC, public water, and on- and off-street parking.

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Medical Office Building
Medical Office Building

2218 George Dr, Opelousas, LA 70570

$299,000
2,822 sqft

Existing medical office suitable for professional or healthcare-related reuse.

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Wood-Floored Flex Space
Wood-Floored Flex Space

129 W Landry Street, Opelousas, LA 70570

$147,000
580 sqft 0.08 AC lot

Commercially zoned property with central heating, central air, and assigned as well as on-street parking.

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Office Building at Signalized Corner
Office Building at Signalized Corner

135 E Landry St, Opelousas, LA 70570

$600,000
6,993 sqft

DMU-zoned commercial building with a former banking layout in downtown Opelousas.

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Office and Flex Space Building
Office and Flex Space Building

129 Landry St, Opelousas, LA 70570

$147,000
580 sqft

Downtown Opelousas building with a large open front area and a separate rear flex space.

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Updated Medical Office Building
Updated Medical Office Building

828 Creswell Lane, Opelousas, LA 70570

$250,000
4,516 sqft 0.26 AC lot

Updated medical office building in commercial zoning, currently leased to a tenant.

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Medical Office with NNN Lease
Medical Office with NNN Lease

828 Creswell Ln, Opelousas, LA 70570

$250,000
4,516 sqft

Medical office property occupied by a medical tenant under a five-year NNN lease with annual escalations.

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Former Medical Office Building
Former Medical Office Building

528 E Vine St, Opelousas, LA 70570

Contact for pricing
7,010 sqft

Former medical office space with convenient access and parking along a busy commuter and retail thoroughfare.

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Victorian-Style Office Building
Victorian-Style Office Building

613 S Main St, Opelousas, LA 70570

$235,000
3,361 sqft

Character-rich office property with private rooms, on-site parking, and NMU zoning.

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Opelousas, LA Office Spaces Lease Rates & Market Statistics

Browse 11 Office Spaces for lease in Opelousas, LA on Realmo, a commercial real estate marketplace serving the Opelousas area. The current inventory totals 56,323 square feet of properties — an average of ~5,100 SF per listing.

Asking lease rates for Office Spaces in Opelousas start at $3.25 SF/Yr, average $10.92 SF/Yr, and reach $13.03 SF/Yr at the top of the market. That's a 4x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $10.92 SF/Yr is 54% below the Louisiana state average of $24.01 SF/Yr.

Opelousas accounts for 92% of the 12 office spaces currently available across St. Landry County, where a nearby market includes Eunice. By space type, the market includes 7 office units and 5 medical office space listings.

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