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Opelousas, LA Office Spaces for Lease

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Church Point, LA Carencro, LA Arnaudville, LA Lafayette, LA Ville Platte, LA Scott, LA Breaux Bridge, LA Eunice, LA
10 properties
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Medical Office with Exam Rooms
Updated: Oct 14
Medical Office with Exam Rooms

827 N Union Street, Opelousas, LA 70570

Contact for pricing
2,500 sqft 0.17 AC lot
2,500 square feet of medical office space
Four exam rooms, two private offices, and a larger exam/lab room
Waiting area and dedicated reception space
Employee kitchen, two restrooms, and two storage rooms
Central heating and air conditioning
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Industrial Warehouse with Loading Dock
Updated: Jan 8
Industrial Warehouse with Loading Dock

1802 W Landry Street, Opelousas, LA 70570

$625,000/Mo
37,000 sqft 3.25 AC lot
37,000 square feet of combined warehouse and office space
30,000‑square‑foot area with 13‑foot ceilings; rear 7,000‑square‑foot section has 18‑foot ceilings
Front overhead door is 12 feet wide; rear overhead door is 7 feet wide and served by a loading dock
More than 20,000 square feet of paved parking on a 3.25‑acre site
Metal roof installed around 2016
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Retail Space with Private Offices
Retail Space with Private Offices

1004 Creswell Lane, Opelousas, LA 70570

Contact for pricing
1,665 sqft 0.15 AC lot

An adaptable interior combines open floor area with private offices and a shared break space.

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Medical Office Built-Out Suite
Medical Office Built-Out Suite

816 Creswell Ln, Opelousas, LA 70570

$4,697/Mo
4,326 sqft

Large office suite with a reception area, file room, and numerous offices in a physician-practice buildout.

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Office Suite with Reception Area
Office Suite with Reception Area

816 Creswell Lane, Opelousas, LA 70570

Contact for pricing
4,326 sqft

Commercial zoning and a layout configured for office use support a range of business operations.

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Warehouse with Office and Yard
Warehouse with Office and Yard

1427 West Linwood Drive, Opelousas, LA 70570

$5,250/Mo
19,358 sqft 0.50 AC lot

Flex-style setup with a stabilized yard, office space, and warehouse access via grade-level and half-dock doors.

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Professional Office Units
Professional Office Units

2414 Jake Dr, Opelousas, LA 70570

$2,200/Mo
2,080 sqft

Office space in a C-1 plaza with parking accommodations, available beginning April 1, 2026.

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Professional Office Unit
Professional Office Unit

2410 Jake Drive, Opelousas, LA 70570

$1,600/Mo
1,520 sqft

Commercially zoned space suited to insurance, accounting, finance, or health care operations.

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Medical Office Space With Easy Access
Medical Office Space With Easy Access

528 E Vine St, Opelousas, LA 70570

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7,010 sqft

Former medical office along Hwy 190 with easy access and approximately 7,000 SF suited for professional office use.

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Medical Office Suite Off I-49
Medical Office Suite Off I-49

5620 I 49 S Service Rd, Opelousas, LA 70570

$3,000/Mo
3,014 sqft

Office suite available right off I-49 in Opelousas, offering a convenient location for medical users.

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Based on your search, we've compiled 29 Potential Opportunities for your consideration. Besides 10 Active listings in Opelousas, LA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 15 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Two-Floor Flex Space with Storage
Two-Floor Flex Space with Storage

310 E Gloria Switch Rd, Lafayette, LA 70507

$1,700/Mo
3,240 sqft

Flexible facility combines office, temperature-controlled storage, and warehouse space with roll-up access.

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Retail or Office Suite in Center
Retail or Office Suite in Center

105-107 Hector Connoly Rd, Carencro, LA 70520

$2,300/Mo
1,400 sqft

Lease a flexible retail or office space within a multi-tenant center featuring established local co-tenancy.

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Retail Space in Commercial Center
Retail Space in Commercial Center

107 Hector Connoly Rd, Carencro, LA 70520

$2,300/Mo
1,400 sqft

Flexible commercial suite suitable for retail, service, or professional office use with access near I-49.

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Flex Facility with Shop Space
Flex Facility with Shop Space

113 E Gloria Switch Road, Lafayette, LA 70507

$9.50 SF/Yr
15,772 sqft

Flexible commercial facility combines showroom-style office space with warehouse and service areas.

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Similar Spaces for Sale in Opelousas, LA

Consider Similar Space for Sale. We found 15 Spaces matching your search parameters.

Downtown Office Building
Downtown Office Building

103 E Bellevue St, Opelousas, LA 70570

$950,000
13,060 sqft

DMU-zoned commercial property with space suited to banking, mortgage, or professional office operations.

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Two-Story Office Building
Two-Story Office Building

505 S Court Street, Opelousas, LA 70570

$250,000
3,642 sqft 0.24 AC lot

Six private offices and a conference room support a multi-room professional layout.

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Medical Office with NNN Lease
Medical Office with NNN Lease

828 Creswell Ln, Opelousas, LA 70570

$250,000
4,516 sqft

Medical office property occupied by a medical tenant under a five-year NNN lease with annual escalations.

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Standalone Office Building
Standalone Office Building

523 S Main St, Opelousas, LA 70570

$110,000
1,500 sqft

Vacant professional workspace with potential for medical, legal, or creative office use.

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Two-Story Office Building
Two-Story Office Building

505 S Court St, Opelousas, LA 70570

$250,000
3,642 sqft

Functional layout includes private offices, conference space, and support areas.

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Medical Office Building
Medical Office Building

507 N Market St, Opelousas, LA 70570

$187,000
2,371 sqft

Brick medical office building with updated interior systems, lobby/reception layout, and rear employee parking.

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Standalone Office Building
Standalone Office Building

523 S Main Street, Opelousas, LA 70570

$110,000
1,500 sqft 0.09 AC lot

Vacant and commercially zoned, the property has central heating and air, tile and carpet flooring, and public water and sewer.

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Victorian-Style Office Building
Victorian-Style Office Building

613 S Main St, Opelousas, LA 70570

$235,000
3,361 sqft

Character-rich office property with private rooms, on-site parking, and NMU zoning.

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Medical Office Building
Medical Office Building

2218 George Dr, Opelousas, LA 70570

$279,000
2,822 sqft

Existing medical office suitable for professional or healthcare-related reuse.

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Office Building at Signalized Corner
Office Building at Signalized Corner

135 E Landry St, Opelousas, LA 70570

$600,000
6,993 sqft

DMU-zoned commercial building with a former banking layout in downtown Opelousas.

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Former Medical Office Building
Former Medical Office Building

528 E Vine St, Opelousas, LA 70570

Contact for pricing
7,010 sqft

Former medical office space with convenient access and parking along a busy commuter and retail thoroughfare.

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Warehouse with Refrigerated Storage
Warehouse with Refrigerated Storage

2418 Powers Street, Opelousas, LA 70571

$369,000
10,400 sqft 0.88 AC lot

A separate office component and two distinct warehouse areas support varied facility functions.

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Medical Office Space with Rear Parking
Medical Office Space with Rear Parking

507 N Market Street, Opelousas, LA 70570

$169,000
2,371 sqft

A reception area, private offices, and three bathrooms support a functional professional-services layout.

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Office Building with Conference Room
Office Building with Conference Room

223 S Main Street, Opelousas, LA 70570

$196,500
2,100 sqft

A varied office layout includes private work areas, meeting space, a kitchen, and two storage rooms.

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Opelousas, LA Office Spaces Lease Rates & Market Statistics

Browse 10 Office Spaces for lease in Opelousas, LA on Realmo, a commercial real estate marketplace serving the Opelousas area. The current inventory totals 82,799 square feet of properties — an average of ~8,300 SF per listing.

Asking lease rates for Office Spaces in Opelousas start at $3.25 SF/Yr, average $42.71 SF/Yr, and reach $202.70 SF/Yr at the top of the market. The local average of $42.71 SF/Yr is 71% above the Louisiana state average of $24 SF/Yr.

Opelousas accounts for 91% of the 11 office spaces currently available across St. Landry County, where a nearby market includes Eunice. By space type, the market includes 7 office units and 5 medical office space listings — medical office space options typically offer the lowest entry point, while office units command the highest rates.

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