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    Port Saint Lucie, FL Office Properties & Spaces for Lease

    22 results
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    Mixed-Use Property Near Turnpike
    $3,300 / Mo
    1,524 SF

    Mixed-Use Property Near Turnpike

    1892 SW Biltmore St, Port Saint Lucie, FL 34984

    Flexible mixed-use property with residential and commercial potential.

    • Oversized 10,000 SF lot with outstanding flexibility.
    • Ideally located minutes from Florida's Turnpike and I‑95.
    • Suitable for service‑based professionals or outdoor‑oriented businesses.
    • Includes a 3‑bedroom, 2‑bath home adaptable for residence, office, or storage.
    • Recent improvements include a new roof, modern plank tile flooring, and updated kitchen.
    Updated: Jan 17
    View details
    Profitable Office Space with Tenants
    $275,000

    Profitable Office Space with Tenants

    544 NW University Blvd Blvd, Port Saint Lucie, FL 34986

    Turnkey office property with long-term tenants and immediate cash flow.

    • Immediate cash flow from day one.
    • Long‑term tenants in place with a proven track record.
    • Tenants recently renewed their leases for an additional two years.
    • 1,056 sq ft office property.
    • Built in 2006.
    Updated: Nov 7, 2025
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    Jetson Plaza Retail Spaces
    $30 SF/Yr
    31,348 SF

    Jetson Plaza Retail Spaces

    Port St. Lucie Medical & Retail Suites

    1908 Gatlin Blvd, Port Saint Lucie, FL 34953
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    Port St. Lucie Flex Building
    $14 SF/Yr
    48,720 SF

    Port St. Lucie Flex Building

    Industrial flex building with air-conditioned office space for lease.

    651 NW Enterprise Dr, Port Saint Lucie, FL 34986
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    St. Lucie West Office Space
    $23 SF/Yr
    45,416 SF

    St. Lucie West Office Space

    Professional and Medical office space in landmark building for lease.

    1660 SW St. Lucie Blvd West, Port Saint Lucie, FL 34986
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    St Lucie West Professional Offices
    $25 SF/Yr
    3,076 SF

    St Lucie West Professional Offices

    Medical and professional offices in the heart of St Lucie West.

    525 NW Lake Whitney Pl, Port Saint Lucie, FL 34986
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    Shared Medical Office Space
    $3,500 / Mo
    1,604 SF

    Shared Medical Office Space

    Shared medical office space available near hospital and major roadways.

    10377 S Us Hwy, Port Saint Lucie, FL
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    Port Saint Lucie Office Space
    $22 SF/Yr
    8,500 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie.

    584 NW University Blvd, Port Saint Lucie, FL 34986
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    Port Saint Lucie Office Space
    $15 SF/Yr
    13,029 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie, FL.

    900 E Prima Vista Blvd, Port Saint Lucie, FL 34952
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    Medical Office Space For Rent
    $25 SF/Yr
    1,288 SF

    Medical Office Space For Rent

    Medical office space in Gatlin Kidney Care medical facility.

    1631 SW Gatlin Blvd, Port Saint Lucie, FL 34953
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    Office Space For Lease
    $14 SF/Yr
    1,600 SF

    Office Space For Lease

    Office space available for lease in Port Saint Lucie, FL.

    8402 S Us Hwy, Port Saint Lucie, FL
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    New Class A Medical Space
    $32 SF/Yr
    2,616 SF

    New Class A Medical Space

    End-cap space in new medical building on Gatlin Blvd.

    1070 SW Gatlin Blvd, Port Saint Lucie, FL 34953
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    Port St. Lucie Office Space
    $27 SF/Yr
    2,500 SF

    Port St. Lucie Office Space

    2,500 SF office space in a thriving commercial corridor.

    155 SW Port St Lucie Blvd, Port Saint Lucie, FL 34984
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    Port St. Lucie Office Space
    $18 SF/Yr
    3,753 SF

    Port St. Lucie Office Space

    Versatile office space in a high-traffic Port St. Lucie location.

    7664 S Us Hwy, Port Saint Lucie, FL
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    Port St. Lucie Office Suite
    $3,114 / Mo
    833 SF

    Port St. Lucie Office Suite

    Executive office suite in Port St. Lucie medical corridor.

    2100 SE Hillmoor Dr, Port Saint Lucie, FL 34952
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    Tradition Village Office Space Available
    $27 SF/Yr
    2,965 SF

    Tradition Village Office Space Available

    Office space in a dynamic live-work-play community.

    10801 S Village Center Dr, Port Saint Lucie, FL 34987
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    Furnished Office Space Available
    $15 SF/Yr
    5,111 SF

    Furnished Office Space Available

    Professional office space with multiple configurations, fully furnished and equipped.

    526 SW Port St Lucie Blvd, Port Saint Lucie, FL 34953
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    Professional Office Space For Lease
    $900 / Mo
    700 SF

    Professional Office Space For Lease

    Two-story office building with recent renovations and ample parking.

    550 SE Port St Lucie Blvd, Port Saint Lucie, FL 34953
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    Visible Corner Office Space Available
    $24 SF/Yr
    1,250 SF

    Visible Corner Office Space Available

    Highly visible office space with excellent exposure and convenient access.

    481 SW Port St Lucie Blvd, Port Saint Lucie, FL 34953
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    Retail, Office, Medical Space Available
    $44 SF/Yr
    1,184 SF

    Retail, Office, Medical Space Available

    New retail, office, and medical space for rent.

    1449-1479 SW Gatlin Blvd, Port Saint Lucie, FL 34953
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    Single-Story Office Building For Rent
    $22 SF/Yr
    4,020 SF

    Single-Story Office Building For Rent

    Single-story office building with immediate availability and hurricane impact glass.

    120-128 SW Chamber Ct, Port Saint Lucie, FL 34986
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    Office Space For Rent
    $22 SF/Yr
    1,629 SF

    Office Space For Rent

    Office space available for lease in Port Saint Lucie, FL.

    1631 NW St Lucie Blvd West, Port Saint Lucie, FL
    View details
    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 22 Active listings in Port Saint Lucie, FL, we suggest exploring alternatives. Similar 4 Properties for Sales.

    Explore Similar Spaces for Sale in Port Saint Lucie, FL

    Consider Similar Space for Sale. We found 4 Spaces in Nearby Locations matching your search parameters.

    Turn-Key Commercial Condo in St. Lucie
    $1,300,000
    4,458 SF

    Turn-Key Commercial Condo in St. Lucie

    4500+ SF commercial condo in St. Lucie West.

    266 NW Peacock Blvd, Port Saint Lucie, FL 34986
    View details
    Tilt-Wall Building in Port St. Lucie
    $3,750,000
    23,756 SF

    Tilt-Wall Building in Port St. Lucie

    23,756 SF tilt-wall building on 2.3 acres for sale.

    529 NW Prima Vista Blvd, Port Saint Lucie, FL 34983
    View details

    Port Saint Lucie, FL Office Properties & Spaces Leasing Opportunities Market Analysis

    Explore Office Properties & Spaces leasing options in Port Saint Lucie, FL with 26 listings featured on our commercial real estate exchange. The current inventory includes 7,956,930,960 square feet of properties with an estimated lease value of $513 /Mo.

    Estimated lease rates for Office Properties & Spaces in Port Saint Lucie, FL begin at $14 SF/Yr, with an average of $24 SF/Yr and extend to $44 SF/Yr.
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    Browse Office Properties & Spaces for Lease Near Port Saint Lucie, FL

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    Most Searched ZIP Codes in Port Saint Lucie, FL

    • 34953
    • 34986
    • 34952
    • 34984
    • 34987
    • 34983

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