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    Port Saint Lucie, FL Commercial Real Estate for Lease

    44 results
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    Medical Building in Port St. Lucie
    $25 SF/Yr
    10,032 SF

    Medical Building in Port St. Lucie

    1405 SE Goldtree Drive, Port Saint Lucie, FL 34952

    Turnkey medical building near HCA Florida St. Lucie Hospital.

    • Turnkey & Completely Built‑out Medical Building Ready for Immediate Occupancy
    • Located in Prominent Medical Area Adjacent to HCA Florida St. Lucie Hospital
    • Approximately 10,032 sqft Available with Flexible Configuration (Contiguous or 5 Suites)
    • Approximately 50 Parking Spaces
    • NNN Lease at $25/sqft plus CAM $8.43/sqft with 2% Annual Increases
    Updated: Feb 23
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    Versatile Commercial Property in Port St. Lucie
    $1,500,000
    1,242 SF

    Versatile Commercial Property in Port St. Lucie

    1892 SW Biltmore Street, Port Saint Lucie, FL 34984

    Two properties with flexibility for commercial or residential use.

    • High‑visibility location in a rapidly growing commercial corridor of Port St. Lucie.
    • Combined sale of two properties (481 SW Voltaire Ave and 1892 SW Biltmore St) totaling approximately 0.55 acres.
    • Excellent proximity to Florida's Turnpike and I‑95.
    • Oversized parcels with excellent frontage, ample parking, and fully usable fenced outdoor space.
    • Single‑family structures on each site offer flexibility for residential, office, or business use.
    Updated: Mar 5
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    Profitable Office Space with Tenants
    $275,000

    Profitable Office Space with Tenants

    Turnkey office property with long-term tenants and immediate cash flow.

    544 NW University Blvd Boulevard, Port Saint Lucie, FL 34986
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    Port St. Lucie Flex Building
    $14 SF/Yr
    48,720 SF

    Port St. Lucie Flex Building

    Industrial flex building with air-conditioned office space for lease.

    651 NW Enterprise Dr, Port Saint Lucie, FL 34986
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    Retail Spaces on US Highway 1
    $1,360 /Mo
    11,120 SF

    Retail Spaces on US Highway 1

    Retail spaces available in a busy Port St. Lucie shopping center.

    10502-10558 S US Highway 1, Port St. Lucie FL 34952, Port Saint Lucie, FL 34952
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    Westport Plaza Retail Space Available
    $29 SF/Yr
    2,124 SF

    Westport Plaza Retail Space Available

    Retail space in Westport Plaza with high traffic and visibility.

    2854-2872 SW Port St Lucie Blvd, Port Saint Lucie, FL
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    Port St. Lucie Retail Space
    $20 SF/Yr
    4,050 SF

    Port St. Lucie Retail Space

    Retail space for lease in Port St. Lucie, Florida.

    7630 S US Hwy 1, Port Saint Lucie, FL
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    Port St. Lucie Office Space
    $27 SF/Yr
    2,500 SF

    Port St. Lucie Office Space

    2,500 SF office space in a thriving commercial corridor.

    155 SW Port St Lucie Blvd, Port Saint Lucie, FL
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    Industrial Space Available For Lease
    $15 SF/Yr
    2,500 SF

    Industrial Space Available For Lease

    2,500 square feet of industrial space for rent.

    574 NW Mercantile Pl, Port Saint Lucie, FL
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    St. Lucie West Flex Space
    $20 SF/Yr
    3,600 SF

    St. Lucie West Flex Space

    Flexible bays near I-95 and Florida’s Turnpike.

    664 NW Enterprise Dr, Port Saint Lucie, FL
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    St. Lucie West Flex Space
    $20 SF/Yr
    5,400 SF

    St. Lucie West Flex Space

    Flex space near I-95 and Florida Turnpike.

    660 NW Enterprise Dr, Port Saint Lucie, FL
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    Industrial Flex Condo For Rent
    $17 SF/Yr
    1,200 SF

    Industrial Flex Condo For Rent

    Versatile 1,200 SF industrial flex condo with offices.

    1547-1561 SE South Niemeyer Cir, Port Saint Lucie, FL
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    St Lucie West Professional Offices
    $25 SF/Yr
    3,076 SF

    St Lucie West Professional Offices

    Medical and professional offices in the heart of St Lucie West.

    525 NW Lake Whitney Pl, Port Saint Lucie, FL
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    Port St. Lucie Warehouse Space
    $18 SF/Yr
    1,500 SF

    Port St. Lucie Warehouse Space

    1500 SF warehouse space for lease in Port St. Lucie.

    1669 SE South Niemeyer Cir, Port Saint Lucie, FL
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    St. Lucie West Office Space
    $23 SF/Yr
    45,416 SF

    St. Lucie West Office Space

    Professional and Medical office space in landmark building for lease.

    1660 SW St. Lucie West Blvd, Port Saint Lucie, FL 34986
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    Port St. Lucie Land Lease
    $5,416 /Mo

    Port St. Lucie Land Lease

    Land lease opportunity near Publix and Florida's Turnpike.

    1091 SE Port St Lucie Blvd, Port Saint Lucie, FL
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    Retail Space in Tradition
    Contact for pricing
    2,800 SF

    Retail Space in Tradition

    Retail space available in a master-planned community shopping center.

    10770 SW Village Pkwy, Port Saint Lucie, FL
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    Port Saint Lucie Office Space
    $13 SF/Yr
    13,029 SF

    Port Saint Lucie Office Space

    Office space available for lease in Port Saint Lucie, FL.

    900 E Prima Vista Blvd, Port Saint Lucie, FL
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    Medical Office Space For Rent
    $25 SF/Yr
    1,288 SF

    Medical Office Space For Rent

    Medical office space in Gatlin Kidney Care medical facility.

    1631 SW Gatlin Blvd, Port Saint Lucie, FL
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    Port St. Lucie Warehouse Space
    $15 SF/Yr
    2,000 SF

    Port St. Lucie Warehouse Space

    2,000 SF warehouse with office, roll-up doors, ample parking.

    1593 SE Village Green Dr, Port Saint Lucie, FL
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    Warehouse Units with Easy Access
    $18 SF/Yr
    1,500 SF

    Warehouse Units with Easy Access

    Warehouse units with tall ceilings, roll-up doors, and ample parking.

    792 SW Grove Ave, Port Saint Lucie, FL
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    Port St. Lucie Office Space
    $18 SF/Yr
    3,753 SF

    Port St. Lucie Office Space

    Versatile office space in a high-traffic Port St. Lucie location.

    7664 S US Hwy 1, Port Saint Lucie, FL
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    Retail, Office, Medical Space Available
    $36 SF/Yr
    1,184 SF

    Retail, Office, Medical Space Available

    New retail, office, and medical space for rent.

    1449-1479 SW Gatlin Blvd, Port Saint Lucie, FL
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    Port St. Lucie Warehouse Space
    $12 SF/Yr
    10,000 SF

    Port St. Lucie Warehouse Space

    10,000 SF warehouse space with 3-Phase Power for rent.

    10011 S US Hwy 1, Port Saint Lucie, FL
    View details

    Port Saint Lucie, FL Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Port Saint Lucie, FL with 44 listings featured on our commercial real estate exchange. The current inventory includes 6,279,566,040 square feet of properties with an estimated lease value of $217 SF/Yr.

    Estimated lease rates for Commercial real estate in Port Saint Lucie, FL begin at $1.47 SF/Yr, with an average of $18 SF/Yr and extend to $27 SF/Yr.
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    Most Searched ZIP Codes in Port Saint Lucie, FL

    • 34986
    • 34952
    • 34983
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