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    Lake City, FL
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    Lake City, FL Office Spaces for Lease

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    High Springs, FL Branford, FL Coral Gables, FL
    Medical Office Corner Suite
    Updated: Jun 25
    Medical Office Corner Suite

    229 Southwest Main Boulevard, Lake City, FL 32025

    $15 SF/Yr
    Two lease spaces in a Class B medical office built in 1925
    Corner lot with two access points and strong frontage along Main Boulevard
    Traffic count of 13,000± vehicles per day along the major corridor
    Currently configured as a speech/OT therapy center with flexible medical office use
    Surrounded by retail and professional services
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    Updated Office Condo For Rent
    Updated: Nov 25, 2025
    Updated Office Condo For Rent

    1140 SW Bascom Norris Dr, Lake City, FL

    Contact for pricing
    1,801 sqft
    High‑visibility location on Bascom Norris Drive with 14,500 daily vehicle traffic count.
    Easy regional access, located just 1.8 miles from I‑75.
    1,801± SF of updated office space with modern finishes, suitable for medical or professional use.
    Features 8 private offices/patient rooms, including an executive suite with built‑ins.
    Ample parking and prominent signage (monument and on‑building) for enhanced business exposure.
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    Retail and Office Space Available
    Retail and Office Space Available

    879 SW Main Blvd, Lake City, FL 32025

    $12 SF/Yr

    Suites available in plaza with national tenants.

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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 3 Active listings in Lake City, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Historic Medical Office Building
    Historic Medical Office Building

    18635 NW Us Highway 441, High Springs, FL 32643

    $14 SF/Yr

    Historic medical office with five exam rooms, reception, and waiting room, plus outdoor storage and an attached breakroom.

    View details
    Innovative Mixed-Use Tech City Development
    Innovative Mixed-Use Tech City Development

    13000 Tech City Cir, Alachua, FL 32615

    $22 SF/Yr
    270,000 sqft · $495,000/Mo

    Mixed-use campus serving various sectors, including start-ups and manufacturing.

    View details
    Spacious Offices with Ample Parking
    Spacious Offices with Ample Parking

    14435 NW 441 20, Alachua, FL 32615

    $2,800/Mo

    Remodeled offices with meeting room, kitchen, and abundant parking.

    View details
    Live-Work Building for Rent
    Live-Work Building for Rent

    18420 High Springs Main Street, High Springs, FL 32643

    Contact for pricing

    A large live-work building offering multiple areas designed for living and working in the same space.

    View details

    Similar Spaces for Sale in Lake City, FL

    Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

    New Construction Warehouse with Office
    New Construction Warehouse with Office

    372 Southwest Windswept Glen, Lake City, FL 32024

    $1,850,000
    7,500 sqft · 2.01 AC lot

    New 7,500 SF warehouse with office space for sale.

    View details
    Industrial Property with Warehouse and Office
    Industrial Property with Warehouse and Office

    3887 E Us Highway 90, Lake City, FL 32055

    $699,000
    15,000 sqft · 1.72 AC lot

    Fully fenced industrial site with a large warehouse, office, and an on-site apartment for flexible operations.

    View details
    Commercial Building with Road Frontage
    Commercial Building with Road Frontage

    508 N Marion Ave, Lake City, FL 32055

    $249,000

    Open-plan commercial building with rear shared parking, suitable for retail, office, or creative use.

    View details
    Charming Commercial Property Near Downtown
    Charming Commercial Property Near Downtown

    412 South Marion Avenue, Lake City, FL 32025

    $199,900
    1,618 sqft

    1920s building with upgrades, suitable for office or mixed-use.

    View details
    Converted Office Building on Corner
    Converted Office Building on Corner

    236 SW Alachua Ave, Lake City, FL 32025

    Contact for pricing

    Converted office building on high-visibility corner lot in Lake City.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Cleared Lot in Williston
    Cleared Lot in Williston

    33 NW 3RD St, Williston, FL 32696

    $20,000/Mo

    C2-zoned lot in Williston's central business area for rent.

    View details
    Prime Commercial Lot For Rent
    Prime Commercial Lot For Rent

    Tift Avenue N, Tifton, GA 31794

    $7,500/Mo

    0.66 acre commercial lot with high visibility.

    View details
    Prime Commercial Lot For Lease
    Prime Commercial Lot For Lease

    Tift Avenue N, Tifton, GA 31794

    $7,500/Mo

    0.66 acre commercial lot in high-traffic area.

    View details
    WINTER PARK Land Lease Opportunity
    WINTER PARK Land Lease Opportunity

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792

    $8,500/Mo
    23,056 sqft · $4 SF/Yr

    Commercial land lease opportunity in Winter Park, Florida.

    View details

    Lake City, FL Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Lake City, FL with 3 listings featured on our commercial real estate exchange. The current inventory includes 1,801 square feet of properties with an estimated lease value of $27 SF/Yr.

    Estimated lease rates for Office Spaces in Lake City, FL begin at $12 SF/Yr, with an average of $13 SF/Yr and extend to $15 SF/Yr.
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