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    Lake City, FL Office Spaces for Lease

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    High Springs, FL O Brien, FL Live Oak, FL Alachua, FL Lake Butler, FL
    Medical Office Corner Suite
    Updated: Jun 25
    Medical Office Corner Suite

    229 Southwest Main Boulevard, Lake City, FL 32025

    $15 SF/Yr
    Two lease spaces in a Class B medical office built in 1925
    Corner lot with two access points and strong frontage along Main Boulevard
    Traffic count of 13,000± vehicles per day along the major corridor
    Currently configured as a speech/OT therapy center with flexible medical office use
    Surrounded by retail and professional services
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    Based on your search, we've compiled 27 Potential Opportunities for your consideration. Besides 1 Active listings in Lake City, FL, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 22 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    High-Clearance Warehouse with Yard
    High-Clearance Warehouse with Yard

    22429 S US HIGHWAY 441, High Springs, FL 32643

    Contact for pricing
    6,700 sqft 4.00 AC lot

    Highway-fronted warehouse property combines covered storage, vehicle circulation, and office improvements.

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    Historic Medical Office Building
    Historic Medical Office Building

    18635 NW Us Highway 441, High Springs, FL 32643

    Contact for pricing
    0.61 AC lot

    Historic medical office with five exam rooms, reception, and waiting room, plus outdoor storage and an attached breakroom.

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    Spacious Offices with Ample Parking
    Spacious Offices with Ample Parking

    14435 NW 441 20, Alachua, FL 32615

    $2,800/Mo
    2.00 AC lot

    Remodeled offices with meeting room, kitchen, and abundant parking.

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    Remodeled Office Units with Meeting Room
    Remodeled Office Units with Meeting Room

    14435 NW 441, Alachua, FL 32615

    $2,800/Mo
    2,130 sqft 2.00 AC lot

    Updated office layout with private work areas, shared meeting space, kitchen facilities, signage, and parking on both sides.

    View details

    Similar Spaces for Sale in Lake City, FL

    Consider Similar Space for Sale. We found 22 Spaces matching your search parameters.

    Multi-Tenant Office Buildings
    Multi-Tenant Office Buildings

    853 SW SISTERS WELCOME ROAD, Lake City, FL 32025

    $1,400,000
    6,054 sqft

    Two occupied buildings provide an established office setting with potential for future owner occupancy.

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    Highway-Frontage Flex Space
    Highway-Frontage Flex Space

    2832 SW MAIN BLVD., Lake City, FL 32025

    $560,000
    3,168 sqft 1.50 AC lot

    Open lobby, adjoining offices, and garage space support office, storage, and equipment-oriented use.

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    Occupied Income-Producing Office Building
    Occupied Income-Producing Office Building

    885 SW SISTERS WELCOME ROAD, Lake City, FL 32025

    $750,000
    6,054 sqft

    Established commercial setting with existing tenants and future owner-user flexibility.

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    Income-Producing Office Buildings
    Income-Producing Office Buildings

    853 SW SISTERS WELCOME ROAD, Lake City, FL 32025

    $1,400,000
    6,054 sqft

    Two fully occupied office buildings support ongoing tenancy and future owner-user flexibility.

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    Office Building with Leased Tenants
    Office Building with Leased Tenants

    853 SW SISTERS WELCOME ROAD, Lake City, FL 32025

    $650,000
    3,419 sqft

    The property is fully occupied, with leases scheduled to renew in 2027 and 2028.

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    Occupied Office Building
    Occupied Office Building

    853 SW SISTERS WELCOME ROAD, Lake City, FL 32025

    $750,000
    2,635 sqft

    Current tenancy includes leases with renewal dates in 2027 and 2028.

    View details
    Fully Occupied Office Building
    Fully Occupied Office Building

    885 SW SISTERS WELCOME ROAD, Lake City, FL 32025

    $750,000
    6,054 sqft

    Established professional-office setting with tenants in place and lease renewals scheduled through 2028.

    View details
    Historic Mixed-Use Property
    Historic Mixed-Use Property

    398 S MARION Avenue, Lake City, FL 32025

    $355,000
    2,559 sqft 0.32 AC lot

    Two-story commercial property with a separate carriage house, apartment, covered porch, and updated building systems.

    View details
    Historic Two-Story Office Building
    Historic Two-Story Office Building

    433 S MARION AVENUE, Lake City, FL 32025

    $349,900
    3,968 sqft 0.65 AC lot

    Flexible two-story layout with multiple rooms, common areas, and public and private restrooms.

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    Restored Two-Story Office Building
    Restored Two-Story Office Building

    398 S MARION, Lake City, FL 32025

    $355,000
    2,079 sqft 0.32 AC lot

    Historic downtown property with a separate carriage house, apartment, and updated building systems.

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    Office Building with Central Air
    Office Building with Central Air

    853 SW SISTERS WELCOME ROAD, Lake City, FL 32025

    $1,400,000
    6,054 sqft

    Commercial office property with central air conditioning and a 1993 construction date.

    View details
    Fully Occupied Office Building
    Fully Occupied Office Building

    853 SW SISTERS WELCOME ROAD, Lake City, FL 32025

    $650,000
    2,500 sqft

    Established commercial-corridor office asset with long-term occupants and lease renewals scheduled in 2027 and 2028.

    View details
    New Construction Warehouse with Office
    New Construction Warehouse with Office

    372 Southwest Windswept Glen, Lake City, FL 32024

    $1,850,000
    7,500 sqft 2.01 AC lot

    New 7,500 SF warehouse with office space for sale.

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    Historic Two-Story Office Building
    Historic Two-Story Office Building

    398 S Marion Ave, Lake City, FL 32025

    $355,000
    2,559 sqft

    Restored commercial property with updated systems, architectural character, and a separate carriage house with apartment space.

    View details
    Historic Two-Story Office Building
    Historic Two-Story Office Building

    398 S MARION, Lake City, FL 32025

    $355,000
    2,079 sqft

    Commercial General zoning, updated systems, and a separate carriage house support varied business configurations.

    View details
    Fenced Flex Space with Warehouse
    Fenced Flex Space with Warehouse

    3887 E US HIGHWAY 90, Lake City, FL 32055

    $699,000
    15,000 sqft 1.72 AC lot

    Fenced and gated commercial property combining warehouse, office, and apartment components.

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    Multi-Unit Office Building
    Multi-Unit Office Building

    725 Se Baya Dr, Lake City, FL 32025

    $615,000
    5,571 sqft

    Seven office units are split across two floors, with a recently installed roof and strong road exposure.

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    Mixed-Use Property with US-41 Frontage
    Mixed-Use Property with US-41 Frontage

    1226 SW MAIN BLVD, Lake City, FL 32025

    Contact for pricing
    4,512 sqft

    Commercially zoned property with city utilities and access along a major Lake City corridor.

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    Warehouse with Fenced Yard and Office
    Warehouse with Fenced Yard and Office

    196 NE CHESTNUT AVE, Lake City, FL 32055

    Contact for pricing
    7,844 sqft

    Warehouse with multiple roll-up doors and updated climatized office plus fenced industrial yard for secure equipment storage.

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    Fully Occupied Office Building
    Fully Occupied Office Building

    853 SW SISTERS WELCOME ROAD, Lake City, FL 32025

    $650,000

    Established commercial corridor setting with lease renewals scheduled in 2027 and 2028.

    View details
    Commercial Building with Residential Income
    Commercial Building with Residential Income

    1664 Southeast Baya Drive, Lake City, FL 32025

    Contact for pricing
    1,152 sqft

    Commercial building with additional income from residential property.

    View details
    Remodeled Corner Office Buildings
    Remodeled Corner Office Buildings

    663 Se Baya Dr, Lake City, FL 32025

    $345,000
    2,254 sqft

    Two-building office property with cleared interior lots, new rear fencing, and municipal water and sewer service.

    View details

    Lake City, FL Office Spaces Lease Rates & Market Statistics

    Browse 1 Office Spaces listing for lease in Lake City, FL on Realmo, a commercial real estate marketplace serving the Lake City area.

    Asking lease rates for Office Spaces in Lake City start at $15 SF/Yr, average $15 SF/Yr, and reach $15 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $15 SF/Yr is 57% below the Florida state average of $34.66 SF/Yr.

    Lake City accounts for 50% of the 2 office spaces currently available across Columbia County, where a nearby market includes Fernandina Beach.

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