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    Lake City, FL Mixed-use Properties for Sale

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    Lehigh Acres, FL Cape Coral, FL Port Charlotte, FL
    Remodeled Home Office Building
    $259,900
    2,442 SF

    Remodeled Home Office Building

    340 SE Country Club Rd, Lake City, FL 32025

    Remodeled office building with live-work potential in Lake City.

    • Newly remodeled home office building, perfect for living and running a business or leasing for income.
    • Enjoy the benefits of a new A/C, windows, paint, floors, electric throughout, and service panel.
    • Features 8 rooms and 2 bathrooms.
    • Durable metal roof.
    • Galley kitchen and convenient in‑unit washer and dryer.
    Updated: Sep 9, 2025
    View details
    Versatile Commercial Asset with Airbnb Units
    $2,975,000
    9.06 Acres

    Versatile Commercial Asset with Airbnb Units

    1524 NW Main Boulevard, Lake City, FL 32055

    Multi-functional commercial property with retail, industrial, and residential income.

    • Over 26,000 sq ft of versatile space suitable for retail, industrial/warehouse, and mechanic shop use.
    • Strategic location near I‑10, I‑75, and the local airport, offering prime accessibility.
    • Two on‑site Airbnb units provide immediate revenue opportunities.
    • Private lake, expansive walking trails, and outdoor recreation space create a retreat‑like setting.
    • FEMA‑designated protection area ensures reliable cell coverage, beneficial for technology‑dependent operations.
    Updated: Mar 23
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    Versatile Commercial Asset with Income Streams
    $2,975,000
    25,805 SF

    Versatile Commercial Asset with Income Streams

    Multi-functional property with retail, industrial, and residential income potential.

    1524 NW Main Blvd, Lake City, FL 32055
    View details
    Commercial Property with Highway Frontage
    $595,000
    3,168 SF

    Commercial Property with Highway Frontage

    3168 SF commercial property with garage, storage, and parking.

    2832 SW Main Blvd, Lake City, FL 32025
    View details
    Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 4 Active listings in Lake City, FL, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 9 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Gainesville Infill Development Site
    $425,000
    1,076 SF

    Gainesville Infill Development Site

    Mixed-use development opportunity in Gainesville, sold for land value.

    3002 NW 43RD STREET, Gainesville, FL 32606
    View details
    Commercial Property with Mobile Office
    $545,000
    1,200 SF

    Commercial Property with Mobile Office

    Commercial property featuring a mobile home office on almost 5 acres.

    17940 Highway 301, Starke, FL 32091
    View details
    1,318 SF Medical Office For Sale
    $159,500
    1,318 SF

    1,318 SF Medical Office For Sale

    1,318 SF Medical Office For Sale

    7109 NW 11th Pl , SUITE 2, Gainesville, FL 32605
    View details
    Highway Frontage Mixed-Use Property
    $325,000
    2,880 SF

    Highway Frontage Mixed-Use Property

    Mixed-use property with highway frontage, near truck route.

    15043 S Hwy 301, Starke, FL 32091
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    16.48 Acre Commercial Tract
    $3,000,000
    16.68 Acres

    16.48 Acre Commercial Tract

    16.48 acre commercial tract with high visibility and traffic.

    0 W W US HWY 90, Lake City, FL 32024
    View details
    High Springs Land For Sale
    $2,500,000
    36.79 Acres

    High Springs Land For Sale

    36+/- acre mixed-use property in High Springs, Florida.

    NW NW US HWY 441 HIGHWAY NW, High Springs, FL 32643
    View details
    Macclenny, FL Commercial Land
    $1,900,000
    3.00 Acres

    Macclenny, FL Commercial Land

    3-acre commercial land zoned for diverse uses in Macclenny, FL.

    9536 SR 228, Macclenny, FL 32063
    View details
    Gainesville Land Development Opportunity
    $850,000
    620 SF

    Gainesville Land Development Opportunity

    Prime commercial/multi-family land near University of Florida and Newberry Road.

    560 NW 39TH ROAD, Gainesville, FL 32607
    View details

    Explore Off-Market Properties in Lake City, FL

    Consider similar Off-Market properties in Lake City, FL. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    126 Colonial Pl

    126 Colonial Pl

    STORES & APARTMENTS • 0.54 Acres
    Value Estimation by Request
    126 Colonial Pl, Lake City, FL 32025-0608
    View details
    812 Marion Ave

    812 Marion Ave

    OFFICE/RESIDENTIAL (MIXED USE) • 2,756 SF
    Value Estimation by Request
    812 Marion Ave, Lake City, FL 32025-5818
    View details
    197 Waterford Ct

    197 Waterford Ct

    STORE/OFFICE (MIXED USE) • 8,522 SF
    Value Estimation
    $830,000
    197 Waterford Ct, Lake City, FL 32025-0711
    View details
    2018 Main Blvd

    2018 Main Blvd

    STORE/OFFICE (MIXED USE) • 7,974 SF
    Value Estimation
    $745,000
    2018 Main Blvd, Lake City, FL 32025-0025
    View details
    228 Marion Ave

    228 Marion Ave

    OFFICE/RESIDENTIAL (MIXED USE) • 83,595 SF
    Value Estimation
    $9,135,000
    228 Marion Ave, Lake City, FL 32055-3917
    View details
    125 Midtown Pl

    125 Midtown Pl

    STORE/OFFICE (MIXED USE) • 4,100 SF
    Value Estimation by Request
    125 Midtown Pl, Lake City, FL 32025-0766
    View details
    207 Confederate Gln

    207 Confederate Gln

    STORES & APARTMENTS • 7,700 SF
    Value Estimation by Request
    207 Confederate Gln, Lake City, FL 32025-1639
    View details
    3827 Us-441

    3827 Us-441

    Restaurants • 1,770 SF
    Value Estimation by Request
    3827 Us-441, Lake City, FL 32055
    View details
    1100 Marion St

    1100 Marion St

    Mixed-use properties
    Value Estimation by Request
    1100 Marion St, Lake City, FL 32055
    View details

    Lake City, FL Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 13 mixed-use properties for sale in Lake City, FL, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 811,200 square feet of properties for sale, with an estimated market value of $4,689,900.

    Sale prices for multi use buildings in Lake City, FL start at $170,000, averaging $669,985, and reaching up to $2,975,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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