Hesperia, CA Office Spaces for Rent & Lease

Updated: Mar 4

Flexible Mixed-Use Commercial Space

14920 Main St Unit #3, Hesperia, CA 92345

$2,000/Mo

1,000 SF mixed‑use commercial unit
Suitable for retail, professional office, studio, or service‑based use
Located at 14920 Main St Unit #3, Hesperia, CA 92345
Built in 2015
Owner pays water, trash, and sewer service

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Updated: Jul 9

Retail Suite with Office Layout

16455 Main Street, Hesperia, CA 92345

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Suite 15 with approximately 1,500 SF available April 2026
Interior includes reception, two private offices, two additional rooms, open workspace, and one restroom
Located within The Hesperia Center along Main Street
Immediate access to Hesperia Road and the broader High Desert trade area
On‑site parking and signage exposure along a high‑traffic commercial corridor

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Office Suite with Warehouse Space

16490 Walnut Street, Hesperia, CA 92345

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Climate-controlled office and warehouse setup with ample parking and additional storage above, suited to service and professional uses.

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Medical Office Suite with Three Offices

17151 Main Street B, Hesperia, CA 92345

$2,050/Mo

6,000 sqft

Suite B offers three offices and a waiting room for administrative or medical-related use.

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Turn-Key Dental Office Suites

18361 Bear Valley Road 2&3, Hesperia, CA 92345

$3,200/Mo

10,246 sqft

Turn-key dental office suites available in a multi-tenant plaza with street visibility and pylon signage.

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Office Suite with Two Offices

15800 Main St Unit 160, Hesperia, CA 92345

$1,548/Mo

26,942 sqft

In-line office space within a multi-tenant plaza, featuring two completed offices and pylon signage.

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Mezzanine Office Suite

B-12720 Main, Hesperia, CA 92345

$2,544/Mo

1,413 sqft

Configured with multiple private offices, two restrooms, and monument signage.

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Medical Office Suite with Waiting Room

B-17151 Main St, Hesperia, CA 92345

$2,050/Mo

1,500 sqft

Multi-tenant building offers a built-out suite with three offices and a waiting room.

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Medical Office Space Available

17450 Main St H, Hesperia, CA 92345

$3,700/Mo

1,438 sqft

Medical office space for rent in Hesperia, CA.

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Office Suites in Corner Location

F-12050 I Ave, Hesperia, CA 92345

$800/Mo

550 sqft

Two office suites are available in an I Ave Tower building with corner visibility and on-site signage.

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Hesperia Office Space Available

12050 I Avenue F, Hesperia, CA 92345

$800/Mo

550 sqft

Office space for rent in central Hesperia location.

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Freestanding Office Building

16303 Main, Hesperia, CA 92345

$2,819/Mo

Freestanding commercial building with a flexible interior plan, prominent monument/pylon signage, and ample on-site parking.

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Private Office Unit with Exterior Access

15462 Main Street C, Hesperia, CA 92345

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6,988 sqft

Professional office suite with dedicated workspace, private entry, restroom, parking, and landlord-maintained common areas.

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Hesperia Office Space For Rent

15659 Bear Valley Rd, Hesperia, CA 92345

$1,600/Mo

1,000 sqft

Centrally located office space on Bear Valley Rd for rent.

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Updated Retail Space

16183 Main, Hesperia, CA 92345

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3,560 sqft

Flexible storefront suite with an open layout, display glazing, private restroom, and rear storage area.

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Office Unit With Private Offices

10178 I Ave C, Hesperia, CA 92345

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28,710 sqft

Commercial suite with a lobby, three private offices, and an open assembly room.

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Move-In Ready Office Unit

16455 Main St Unit 15, Hesperia, CA 92345

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1,500 sqft

Approximately 1,500 SF with reception, private offices, open workspace, additional rooms, and a restroom.

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Storefront Office Suite with Reception

D-10918 Hesperia Rd, Hesperia, CA 92345

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1,150 sqft

Move-in-ready suite with direct storefront access, reception space, multiple private rooms, and an in-suite restroom.

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Highly Visible Multi-Unit Office Building

16490 Walnut St, Hesperia, CA 92345

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6,000 sqft 0.88 AC lot

Multi-unit office building with ample parking and move-in ready spaces.

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Clock Tower Professional Center Offices

16501 Walnut St Unit 3, Hesperia, CA 92345

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11,690 sqft

Multi-tenant office suites for lease in Hesperia, California.

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Storefront Suite with Private Rooms

10918 Hesperia Road, Hesperia, CA 92345

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1,150 sqft

Professional interior includes reception space, multiple private rooms, and an in-suite restroom.

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Medical Office Suite with Exam Rooms

F-17450 Main Street, Hesperia, CA 92345

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1,438 sqft

Single-story center offers patient and staff entrances, three bathrooms, kitchenette, and private office space.

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Hesperia Center Retail/Office Suites

16455 Main St, Hesperia, CA 92345

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1,500 sqft

Retail and office suites available for lease in Hesperia.

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Medical Office Suite with Exam Rooms

H-17450 Main St, Hesperia, CA 92345

$3,700/Mo

2,177 sqft

Configured for patient-facing operations with reception, treatment space, private offices, and four restrooms.

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Hesperia, CA Office Spaces Lease Rates & Market Statistics

Explore 32 Office Spaces for lease in Hesperia, CA on Realmo, a commercial real estate exchange covering the Hesperia area. The current inventory totals 553,077 square feet of properties — an average of ~17,300 SF per listing.

Asking lease rates for Office Spaces in Hesperia start at $3.75 SF/Yr, average $17.46 SF/Yr, and reach $30.88 SF/Yr at the top of the market. That's a 8x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $17.46 SF/Yr, the local average runs 30% below California's state average of $24.79 SF/Yr.

Hesperia accounts for 6% of the 518 office spaces currently available across San Bernardino County, where nearby markets include Ontario and Rancho Cucamonga. By space type, the market includes 28 office units and 13 medical office space listings.