Hesperia, CA Office Spaces for Rent & Lease

Updated: Mar 4

Flexible Mixed-Use Commercial Space

14920 Main St Unit #3, Hesperia, CA 92345

$2,000/Mo

1,000 SF mixed‑use commercial unit
Suitable for retail, professional office, studio, or service‑based use
Located at 14920 Main St Unit #3, Hesperia, CA 92345
Built in 2015
Owner pays water, trash, and sewer service

View details

Updated: Jul 9

Retail Suite with Office Layout

16455 Main Street, Hesperia, CA 92345

Contact for pricing

Suite 15 with approximately 1,500 SF available April 2026
Interior includes reception, two private offices, two additional rooms, open workspace, and one restroom
Located within The Hesperia Center along Main Street
Immediate access to Hesperia Road and the broader High Desert trade area
On‑site parking and signage exposure along a high‑traffic commercial corridor

View details

Office Suite with Warehouse Space

16490 Walnut Street, Hesperia, CA 92345

Contact for pricing

Climate-controlled office and warehouse setup with ample parking and additional storage above, suited to service and professional uses.

View details

Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center

Medical Office Suite with Three Offices

17151 Main Street B, Hesperia, CA 92345

$2,050/Mo

1,500 sqft

Suite B offers three offices and a waiting room for administrative or medical-related use.

View details

Mezzanine Office Suite

B-12720 Main, Hesperia, CA 92345

$2,544/Mo

1,413 sqft

Configured with multiple private offices, two restrooms, and monument signage.

View details

Medical Office Suite with Waiting Room

B-17151 Main St, Hesperia, CA 92345

$2,050/Mo

1,500 sqft

Multi-tenant building offers a built-out suite with three offices and a waiting room.

View details

Turn-Key Dental Office Suites

18361 Bear Valley Road 2&3, Hesperia, CA 92345

$3,200/Mo

1,600 sqft

Turn-key dental office suites available in a multi-tenant plaza with street visibility and pylon signage.

View details

Medical Office Space Available

17450 Main St H, Hesperia, CA 92345

$3,700/Mo

1,438 sqft

Medical office space for rent in Hesperia, CA.

View details

Main Street Professional Center Unit

17450 Main St E, Hesperia, CA 92345

$2,500/Mo

1,440 sqft 0.63 AC lot

Professional center unit with exam rooms, kitchenette, and private office.

View details

Main Street Professional Center Unit

17450 Main St B, Hesperia, CA 92345

$909/Mo

535 sqft 0.63 AC lot

Professional office unit with easy access and mixed medical uses.

View details

Office Suites in Corner Location

F-12050 I Ave, Hesperia, CA 92345

$800/Mo

550 sqft

Two office suites are available in an I Ave Tower building with corner visibility and on-site signage.

View details

Hesperia Office Space Available

12050 I Avenue F, Hesperia, CA 92345

$800/Mo

550 sqft

Office space for rent in central Hesperia location.

View details

Freestanding Office Building

16303 Main, Hesperia, CA 92345

$2,819/Mo

Freestanding commercial building with a flexible interior plan, prominent monument/pylon signage, and ample on-site parking.

View details

Clock Tower Professional Center Office

16501 Walnut St 3, Hesperia, CA 92345

Contact for pricing

11,690 sqft 0.86 AC lot

Small office suites for lease in Hesperia, California.

View details

Storefront Office Suite with Reception

D-10918 Hesperia Rd, Hesperia, CA 92345

Contact for pricing

1,150 sqft

Move-in-ready suite with direct storefront access, reception space, multiple private rooms, and an in-suite restroom.

View details

Highly Visible Multi-Unit Office Building

16490 Walnut St, Hesperia, CA 92345

Contact for pricing

6,000 sqft 0.88 AC lot

Multi-unit office building with ample parking and move-in ready spaces.

View details

Medical Office Suite with Exam Rooms

F-17450 Main Street, Hesperia, CA 92345

Contact for pricing

1,438 sqft

Single-story center offers patient and staff entrances, three bathrooms, kitchenette, and private office space.

View details

Medical Office Space Available

15462 Main St C, Hesperia, CA 92345

Contact for pricing

678 sqft 1.20 AC lot

Private office space in medical building with exterior access.

View details

Medical Office Suite with Exam Rooms

17450 Main Street H, Hesperia, CA 92345

$3,700/Mo

2,177 sqft

Single-story professional-center space includes patient reception, treatment areas, private offices, and multiple restrooms.

View details

Hesperia Office Space For Rent

15659 Bear Valley Rd, Hesperia, CA 92345

$1,600/Mo

0.70 AC lot

Centrally located office space on Bear Valley Rd for rent.

View details

Medical Office Suite with Private Entrance

D-17450 Main St, Hesperia, CA 92345

$2,448/Mo

Medical office suite with exam rooms, kitchenette, and dedicated front and rear entry for staff and patient access.

View details

Clock Tower Professional Center Offices

16501 Walnut St, Hesperia, CA 92345

Contact for pricing

11,690 sqft

Multi-tenant office suites for lease in Hesperia, California.

View details

Flex Space with Showroom

A3-10902 I Ave, Hesperia, CA 92345

Contact for pricing

Central HVAC, private rooms, and rear roll-up access support a versatile commercial layout.

View details

Hesperia Office and Industrial Space

10400 Amargosa Rd, Hesperia, CA 92345

Contact for pricing

428,185 sqft

Office and industrial space available for rent in Hesperia.

View details

Hesperia, CA Office Spaces Lease Rates & Market Statistics

Explore 32 Office Spaces for lease in Hesperia, CA on Realmo, a commercial real estate exchange covering the Hesperia area. The current inventory totals 497,801 square feet of properties — an average of ~15,550 SF per listing.

Asking lease rates for Office Spaces in Hesperia start at $16.40 SF/Yr, average $20.56 SF/Yr, and reach $30.88 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $20.56 SF/Yr, the local average runs 18% below California's state average of $24.93 SF/Yr.

Hesperia accounts for 6% of the 549 office spaces currently available across San Bernardino County, where nearby markets include Ontario and Rancho Cucamonga. By space type, the market includes 25 office units and 13 medical office space listings.